Objective: The aim of the research was to develop a formulation which has no or less side effects and toxicities, stably accumulates large amount of water, is excellent in cooling effect, offers water retaining for a long duration and has superior functionality e.g. reducing fever, migraine, headache, neuralgia. Methods:  Different formulations were formulated using different polymers like Xanthan gum, HPMC, Carbopol 934 NF, sodium CMC, Guar gum, Gelatin and Ultraze in different ratio. The formulations were evaluated for Physical Appearance, pH, Homogeneity, Viscosity, Consistency, Swelling studies, Loss on drying, Skin irritation test, Stability studies. Results: Formulation C₅ was having good adhesive property and was very easy to apply on the non-woven fabric. The elasticity and viscosity were good and was clear in appearance. All the formulations were evaluated for various parameters and formulation C₅ was most stable among all with good adhesive property, smooth and good elasticity with highest water absorbing capacity and highest cooling effect and this formulation was taken as optimized formulation. Conclusion: From the present investigation it can be concluded that that C₅ formulation showed optimum homogeneity, consistency, viscosity, swelling studies and stability. Cooling gel sheets could be a potential method for reducing fever in near future which can be  replacements for the old method of applying wet cloth on the forehead. The cooling gel sheets could provide cooling for maximum 6-8 hrs with a single sheet.

Catechin is one of the major polyphenolic compounds found in numerous plant species and processed food products. It acts as a primary antioxidant and can be helpful for improving or preventing a number of chronic diseases. A new and simple analytical method using HPLC is developed for estimation of catechin.  The method reported here can be applied for the quantitative analysis of catechin in leaf extract of Guazuma tomentosa, other medicinal plants, herbal formulation and food products.

Rationale:  Fever is basically rise in body temperature above normal. Fever itself is not a disease but it is an indication that the body is trying to fight an illness or an infection. Fever is usually associated with physical discomfort, and most people feel better when the fever is treated. But depending on age, physical condition, and the underlying cause, the patient may or may not require medical treatment for the fever alone. In some cases it is not recommended to treat fever as the rise in temperature is important to kill the viruses and bacteria. These are the causes of the infection but rise in the temperature heats up the body and causes discomfort. There are various approaches to cool the body from the outside without treating the cause of the fever. They include lukewarm or cool wraps or baths, cold drinks and very light clothing. Using a wet cloth on the forehead is an age old remedy for treating fever but the problem with this method is that the cloth needs to be changed after every 1 or 2 minute. Methods: The formulations were evaluated for Clinical trials of the patches. Conclusion: From the present investigation it can be concluded that that C₅ formulation showed optimum homogeneity, consistency, viscosity, swelling studies and stability. Cooling gel sheets could be a potential method for reducing fever in near future which can be  replacements for the old method of applying wet cloth on the forehead. The cooling gel sheets could provide cooling for maximum 6-8 hrs with a single sheet.

Oceans cover more than 70% of the earth surface and the marine environment is highly diverse. Marine floras are taxonomically diverse, largely productive, biologically active and chemically unique offering a great scope for discovery of new anticancer drugs. The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides. The various active anticancer agents are derived from plants and terrestrial microorganisms and the isolation of C-nucleosides from the Caribbean sponge, Cryptothecacrypta, four decades ago, provided the basis for the synthesis of cytarabine that is the first marine derived anticancer agent to be developed for clinical use. Gemcitabine, one of its fluorinated derivatives that has also been approved for use in patients with pancreatic, breast, bladder, and non-small-cell lung cancer. ET-743, Aplidin R and Kahalalide F, has shown to show a positive therapeutic index and activity in resistant solid tumors that supports the ongoing clinical phase II/III trials. ET-743 represents as the first active agent against tumors developed in the past 25 years and has demonstrated a therapeutic potential in pretreated ovarian cancer. In recent times, a 44-member Dilactone macrolide swinholide J, epoxide of swinholide A, a known cytotoxic compound that was reported from the Red Sea sponge Theonellas winhoei and their cytotoxic properties indicated this compound to be less potent against oral carcinoma cell lines.  This review revolves around the latest examinations and affirmations the colossal force of marine life frame as anticancer biomolecule sources