Volume1,Issue2

Volume 1, Issue 2, August 2010 – October 2010

1.Anti–inflammatory activity of calotropis gigantea linn. Leaves extract on in-vitro models.
Jagtap V. A., Md Rageeb Md Usman , Salunkhe P.S., Gagrani M.B.
Abstract
The leaves of Calotropis gigantea are traditionally used to cure cancer1, intermittent fever, paralyzed part of body, painful joints, swelling, heals wounds. Also used as an antispasmodic, antiasthmatic, externally used for piles, boils, ulcers, scabies, eczema, leprosy2. It is having promising anti-inflammatory activity3. However, its anti – inflammatory activity is not scientifically documented. Hence, the present study was under taken to evaluate anti–inflammatory activity of Calotropis gigantea leaves extract using in – vitro method. Calotropis gigantea leaves were subjected to successive extraction4-5 with petroleum ether (60-800), chloroform, ethyl acetate, n-butanol and ethanol and Distilled water and the extract was screened for in vitro anti – inflammatory activity by using inhibition of albumin denaturation technique6 which was studied according to Muzushima and Kabayashi7 with slight modification. Ibuprofen (100mg/kg) was used as standard reference drug. The % inhibition of denaturation produced by ethanolic extract of  Calotropis gigantea leaves was comparable with that produced by Ibuprofen (85.71%) which indicates that Calotropis gigantea leaves extract possess significant anti – inflammatory activity.

2. Liposomes: Present prospective and future challenges
Sharma V. K., Mishra D.N. , Sharma A.K. ,Srivastava B.
Abstract
Liposomes are microscopic (unilamellar or multilamellar) vesicles that are formed as a result of self-assembly of phospholipids in an aqueous media resulting in closed bilayered structures which are under extensive investigation as drug carriers for improving the delivery of therapeutic agents.  Liposomes have been considered as one of the most outstanding, versatile and flexible carrier systems, which offer wide opportunity for the delivery of multifarious molecules and applications. The present review focuses upon preparation and characterization of liposomes plus challenges associated with liposomal delivery

3. Phytochemical Investigation And Effect Of Abutilon Indicum On Various Biochemical Parameters On Stress Induced In Albino Rats
Roshan.S, Savadi. R.V, Tazneem.B, Ali Sadath, Khan Abdullah
Abstract
The present study was carried out to evaluate the effect of ethanolic extract of Abutilon indicum on swimming endurance test and cold induced stress in albino rats. The effect was assessed by swimming survival time and estimation of various biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN) and blood cell count (WBC) and also the differential count. In cold stress by determining the ulcer index and weight of organ such as, liver, spleen, testes, adrenal gland at a dose of and 400mg/kg body weight per oral. It was found that ethanolic extract significantly (p<0.001) increases the swimming time, showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, BUN and plasma cortisol levels.  A significant (p<0.01) decrease in WBC count, polymorphs, monocytes, lymphocytes and eosinophils. In cold stress significant (p<0.001) decrease in ulcer index, protection increase in PH ­of gastric juice. weight of organ was observed to control group. Thus the obtained results revealed that the Abutilon indicum has got a significant anti stress activity.
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