Introduction: Despite many available therapies for wound healing, it’s treatment still remains unsatisfactory. Metformin by virtue of it’s various actions like anti-inflammatory, anti oxidant and effect on hemostatic mechanisms can prove to be promising for the wound healing especially in diabetics. Materials and methods: Wistar rats were divided into two groups, (n=6 each group) and a wound was created which was treated with petroleum jelly in group A and petroleum jelly based Metformin cream in group B. The wound healing and epithelisation of wound was evaluated at day 4,8,12,16 and 20. Results: Group A showed an average wound size of 348±13.0 on day 4, 278±10.5 on day 8, 119±9.8 on day 12, 86±9.2 on day 16 and 100% wound healing was observed day 20 onwards. Group B showed an average wound measurement of 310±10.0 on day 4, 231±9.0 on day 8, 83±8.5 on day 12 and complete wound healing was observed day 16 onwards in the test group. Conclusion: Metformin proved to be useful in wound healing.