The demands for fast dissolving tablets have received ever increasing day by day during the last two decade. In the proposed present project study, the effect of natural Superdisintegrants was compared with synthetic Super disintegrants and conventional Super disintegrants in the of fast dissolving tablet formulation of Etoricoxib. Etoricoxib NSAID is used for the treatment of mild to moderate pain in various conditions like (osteoarthritis) and reducing pain, swelling, and joint stiffness caused with rheumatoid arthritis. In the present work 9 formulations of FDT (Fast dissolving tablet) of Etoricoxib were prepared by using Super disintegrants was evaluated and compiles with the official parameters and specifications. Various formulations were prepared using four different superdisintegrsnts namely natural superdisintegrats Fenugreek Powder, sodium starch glycolate, cross carmelose sodium with three concentrations (4%, 8%, 12%) by direct compression method. Formulation F2 showed the lowest disintegration time and in-vitro dissolution studies recorded that formulation F2 showed 99.55% drug release at the end of 3 minutes. The best formulations among these were also found to be stable and optimized formulations were subjected to the stability studies as per ICH guideline.

Background: Anemia reported during pregnancy is a burdensome public health problem all around the world, problem is vast among developing¬ countries. Women during pregnancy are more prone for developing anemia not only because of increased iron demand and its poor bioavailability along with hemodilution physiological increase in plasma volume (physiological increase in plasma volume) which acts synergistically. Material & Methods: The present study was conducted at the Department of Community Medicine of our medical college over a duration of six months, from June 2020 to December 2020. A sample size of 400 pregnant women was determined using the Epi Info software version 7.2, with a 95% confidence interval and a 10% acceptable margin of error. Results: The findings of the present study reveal notable differences in the burden of anemia among pregnant women, categorized based on their primigravida status and birth intervals. Among primigravida, the majority (54.6%) exhibited no anemia, followed by mild (33.3%) and moderate (12%) cases, with no instances of severe anemia observed. Conversely, among women with birth intervals of less than two years, there were no cases of no anemia, with the prevalence of mild, moderate, and severe anemia standing at 45.6%, 41.4%, and 13%, respectively. Similarly, among those with birth intervals of more than two years, no instances of no anemia were reported, with 34.8%, 63.1%, and 2.2% experiencing mild, moderate, and severe anemia, respectively. These variations in the burden of anemia across different groups were found to be statistically highly significant (p value < 0.001). Conclusions: The study underscores the significant prevalence and impact of anemia, particularly highlighting the elevated risk among rural populations. Moreover, it reveals a noteworthy association between anemia and birth interval, with a higher burden of severe anemia observed among pregnant women with birth intervals of less than two years.