1.SUBLINGUAL TABLET- ADVANCEMENT IN TABLET DOSAGES FORM Ashok Kumar Sharma, Pushpendra Singh Naruka, Shankar Soni, Mohit Khandelwal, Shaneza Aman, Mehul
Sublingual drug delivery is often an alternate and better choice of route in comparison to oral drug delivery as sublingually administered dosage forms bypass hepatic metabolism. A rapid onset of pharmacological effect is usually desired for a few drugs, especially those utilized in the treatment of acute disorders and need onset of action. Sublingual tablets disintegrate rapidly and therefore the bit of saliva present is typically sufficient for achieving disintegration of the dosage form including better dissolution and increased bioavailability with effective therapeutic range. Sublingual tablets were found to possess better characteristics in comparison to standard conventional dosage forms. Sublingually administered tablets achieved better bioavailability, rapid onset of action and better dissolution properties increasing the fast disintegration. The addition of Superdisintegrants facilitated rapid disintegration and this approach is often needed to treat acute disorders or emergency conditions with showing onset of action. The sublingual route of administration is often used for drugs which undergo first pass metabolism or degradation within the GIT process. Drugs administered sublingually tend to possess better bioavailability which is better approach other than conventional tablets.