The demands for fast dissolving tablets have received ever increasing during the last 2-3 decade. In the present project study, the effect of natural Superdisintegrants was compared with synthetic Superdisintegrants and conventional Superdisintegrants in the formulation of fast dissolving tablet formulation of Rizatriptan. The new anti-migraine drug, rizatriptan benzoate is a potent and selectively 5-hydroxytryptamine_1B/1D receptor agonist and is considered as more effective than the other traditional triptans for the treatment of acute migraine attack. In the proposed work 9 formulations of FDTs of Rizatriptan were prepared by using Superdisintegrants was evaluated and compiles with the official parameters with all the specifications. Various formulations were prepared using four different superdisintegrsnts namely natural super disintegrats Fenugreek Powder, sodium starch glycolate, Crospovidone with three concentrations (4%, 6%, 8%) by direct compression method. Formulation F2 showed the minimum disintegration time and in-vitro dissolution studies shows that formulation F2 showed 96.50% drug release at the end of 3 minutes.