International Journal of

Current Pharmaceutical Review and Research

ISSN: 0976 822X Peer Review Journal

doi prefix: 10.25258/ijpqa

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1. Shilajit: An Ancient Panacea
Mohd. Aamir Mirza, Mohd. Naushad Alam, Mohd. Faiyazuddin,Danish Mahmood, Ranjan Bairwa, Gulam Mustafa
Shilajit is a pale-brown to blackish–brown exudates obtained from layer of rocks in many mountain ranges (especially the Himalayan ranges of the Indian subcontinent) of the world. Its curative potentials were found documented in ancient books and were used to treat many ailments since antiquity days. Major portion of Shilajit was found to consist of humic substances. A number of preclinical trials have shown many of its pharmacological properties. Use of its constituent in modern agriculture is a common practice nowadays. Several researches have been carried out that explored its curative potential and this miraculous gift of God is finally made available to pharmaceutical industry.

2.Enhancement of Flow Property of Poorly Flowable Aceclofenac Drug Powder by Preparation of Spherical Crystals using Solvent Change Method and Making Drug Powder Suitable for Direct Compression
M. M. Gupta, B.Srivastava
Aceclofenac spherical crystals were prepared by using a three solvent system comprising ethanol, dichloromethane (DCM), and water (good solvent, bridging liquid and bad solvent, respectively). Polyvinyl Pyrollidone (PVP-K-30) in different concentrations was used as hydrophilic polymer. The effect of speed of rotation, agitation time, temperature, mode of addition of bridging liquid, amount of bridging liquid as well as effect of different amounts of non-solvent ( water) on spherical crystals were studied. The crystals were subjected to various evaluations such as %yield, drug content, particle size and particle size distribution, % fines, crushing strength, friability, packability and compression behaviour of spherical crystals(agglomerate) The agglomerates showed improved micromeritic properties as well as dissolution behaviour in comparison to conventional drug crystals. The optimized agglomerates showed good sphericity as well as high drug release, and hence they were compressed into tablets by direct compression.

3. Deficiency of Vitamin K Linked to Cancer, Osteoporosis and Heart Diseases
Asia Tabasum and Muhammad Imran Qadir
Studies demonstrate that vitamin K has been established to include an anti-cancer effect equally in cancer cells in the laboratory and in animals. Studies concluded that intake of vitamin K in food is coupled with a lesser risk of occasional and critical cancer. Menaquinone reduce and stop bone loss and helpful in the controling the  disorders of bone in women with cirrhosis of the liver. Deposition of calcium in bon due to vitamin K2 has totally reverse effect on the circulatory system by activating a protein called the Matrix Gla Protein (MGP). MGP is known to avoid the build up on calcium in arteries but it doesn’t work without the occurrence of enough vitamin K.

4. Need for Hormonisation of Labelling of OTC drugs
Rajendra K. Songara, Yashwant, Manmohan Singhal, Vipul Gupta, Promila
Over the counter (OTC) drugs are medicine that may be sold without a prescription and without a visit to a medical professional in contrast to prescription drugs. Reading the product label is the most important part of taking care of when using OTC medicines. There is increasing need for consumer to have easily readable and understandable information about OTC drugs. Information on active ingredients, warnings, indications, storage conditions, contraindications, directions, purposes and other information, must be legible and accessible as OTC drug products are now widely available and used without medical supervision. This is particularly important because many potent drugs which have been switched from prescription to OTC status. Consumers are becoming more actively involved in there own health care, and are practicing self-diagnosis and self-medication with OTC drug products. Thus, it is extremely important that OTC drug product be clearly and uniformly labeled in a simple manner so as to ensure there safe and effective use by consumers.

5. Nutritional Supplements: An Overview
Raj Kumar Keservani, Rajesh Kumar Kesharwani, Anil Kumar Sharma, Narendra Vyas, Anoop Chadokar
There is need for those within the industry to become more vigilant in their use of terminology with increasing consumer awareness as it applies to terms such as nutraceutical, functional, medical and novel foods. Dietary supplements have also been developed to manage a variety of diseases. Recognition of variation in functional food and nutraceutical composition will provide opportunity for the industry to give consumers a variety of new products that can be developed for niche or specialized markets.

6. A Probable Target for Novel Anticancer Agents: Cdc25 Phosphatases as Cyclin-Dependent Kinase Inhibitors
Yashwant, B.Srivastava, Brij K. Sharma, Kalpesh Gaur
There are many different types of cancer, but all share a common feature – rapid and uncontrolled cell proliferation. Emergence of new tumors is associated with mutations or abnormalities in expression of various cell cycle regulators like cyclins and cyclindependent kinases (Cdk). Cell Division Cycle 25 (Cdc25) Phosphatases are DualSpecificity Phosphatases (DSP) that dephosphorylate and activate the Cdk/cyclin complexes, thereby playing a fundamental role in transitions between cell cycle phases.
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