1. STUDY ON THE COMPLICATIONS A PREGNANT WOMEN FACES WHO SUFFERS FROM POLYCYSTIC OVARY SYNDROME (PCOS) Sakshi Singhal, Yogesh Kumar Sharma
Polycystic ovary syndrome affects 6 to 15% of reproductive age women worldwide. Women diagnosed with polycystic ovary syndrome (PCOS) have focused on diagnosis, menstrual cycle abnormalities, hirsutism and infertility. It is associated with increased risk of miscarriage, gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy, preeclampsia, preterm delivery, and birth of small for gestational age infant. This review aims to summarize current knowledge regarding the clinical and pathophysiological features of pregnancy and children in women with PCOS.
2. AMPHOTERICIN-B: A DRUG APPROACH IN FUNGAL TREATMENT Ashok Kumar Sharma, Pushpendra Singh Naruka, Shankar Lal Soni, Vani Madaan, Vandana Sharma, Mukesh Sharma
Amphotericin B (AmB) is a polyene macrolide class of antifungal agent and it is the drug of choice for systemic fungal infection, but unfortunately, oral bioavailability of this drug is negligible due to its low aqueous solubility. Amphotericin-B is a potent and effective antifungal medication used for serious fungal infections. It is used to treat aspergillosis, blastomycosys, candidiasis and cryptococcosis and many other fungal infection. It is typically given by injection into a vein, now a day’s it used topically like-cream and gel. Common side effects fever, chills, headaches and Naphrotoxicity (kidney problem). Amphotericin-B act as forming pores in cell membrane that causes leakage of monovalent ions and subsequent fungal cell death.
3. A REVIEW ON ANTI AGING HERBAL FACE CREAM Rakesh Mandal, Rupesh Singh, Ashok Saini, Vandana Sharma, Mukesh Sharma, Ashok Kumar Sharma, Vani Madaan
According to research, skin aging results in a constant deteriorating process due to protein and cellular DNA damage. The primary goal is to formulate an anti-aging herbal cream utilizing only natural ingredients; Amla, curcuma longa, hibiscus, pipper-mint, olive oil, vitamin E, green tea, coconut oil, aloe vera, basil oil, and other natural APIs include pomegranate and ginseng. Natural ingredients are used to create this water-in-oil emulsion-based cream. All of the substances together can be considered a multifunctional cream, and further studies on the cream’s stability and irritancy on skin can be conducted.
COVID-19 may be a very contagion caused by a recently discovered called corona virus. Novel corona virus was found in December 2019 in Wuhan, China. World Health Organization has declared the COVID-19 as pandemic disease and outbreak as a health emergency globally. Novel Corona Virus is additionally referred to as severe acute respiratory syndrome corona virus- 2. The foremost infected people with corona virus show commonly respiratory illness like- fever, cold, sneezing, cough, pneumonia, upper respiratory illness, GIT disease like nausea, vomiting as symptoms. Recently published evidences stated that light Fever and cough within the 80 % patients, shortness of breath in 30-35% patients and 10-15% patients show Muscle ache and other ache. Novel Corona virus enters through the membrane ACE-2 receptor within the human cell. Corona virus is spherical or pleomorphic, single stranded, enveloped ribose macromolecule and included club shaped glycoprotein. SARS, Respiratory (breathing) infections are often transmission via droplets of various diameter like >5-10 micrometer. Molecular test administered with respiratory samples, like throat swab, sputum and broncholveolar lavage and in some severe cases it reported in stool and blood also. After the WHO and other diagnostic guideline said that the PCR and RT-PCR test reported for corona diagnosis.