1. DEVELOPMENT AND EVALUATION HYDROGEL OF KETOCONAZOLE Ashok Kumar Sharma, Pushpendra Singh Naruka, Shankar Soni, Mohit Khandelwal, Shaneza Aman, Mukesh Sharma
The main aim of this study was to develop a topical drug delivery (Hydrogel) of Ketoconazole to reduce the dose of the active drug, to improve patient compliance, to avoid the side effects and increase local onset absorption and action. Ketoconazole interfare with 14-α sterol demethylase, a cytochrome P-450 enzyme essential for conversion of lanosterol to ergosterol. These turn in inhibition in synthesis of ergosterol and also enhance cellular permeability of fungus due to reduced amounts of ergosterol present in the fungal cell membrane. Methods: Topical Hydrogel formulations development of Ketoconazole was prepared by using Different-different polymers by enhancer stability and viscosity with their different concentrations. Six different formulations of Ketoconazole were prepared and evaluated parameters with respect to their colour, Spreadability, viscosity, determination of pH, drug content of formulations, in vitro drug release studies, and stability studies. Results: FT-IR study results that there were not any interaction between the drug, Polymers, and excipients. All the developed formulations of Ketoconazole show acceptable standard physical properties. The drug content and percentage yield were higher for F5 formulation among all formulation. F5 shows better drug release. Stability study of the best formulation F5 with guar gum polymer was found with best results. Conclusion: From the above observation results that this F5 formulation may be more effective topical formulation for the healing of fungal infections in the skin.