International Journal of Current Pharmaceutical

Review and Research

e-ISSN: 0976 822X

p-ISSN: 2961-6042

NMC Approved Peer Review Journal

Menu

Disclaimer: Scopus, Embase, Publons and Crossref are registered trademark of respective companies.

This journal is member of Crossref. 

1. Study to Evaluate the Knowledge, Attitude & Practice of Pharmacovigilance in Health Care Personnel: A Cross-Sectional Study
Nilesh Patil, Mohmed Sohel Shaikh, Hitesha Trivedi, Suraj Tripathi
Abstract
Background: Pharmacotherapy is an integral part of combating a disease or its symptoms. Drug therapy for a disease has two sides: one is beneficial and the other is harmful. For this, there is a branch for monitoring these types of adverse drug reactions known as Pharmacovigilance. Every healthcare professional should actively participate in pharmacovigilance programs by reporting Adverse Drug Reactions (ADRs) properly instead of only managing the patients. Worldwide reports of ADRs are kept up to date in an international database maintained by the Uppsala Monitoring Centre (UMC, WHO), located in Sweden. Pharmacovigilance programs require attention and evaluation regularly for ADR reporting among new-comer healthcare Personnel in the medical field. Objective: To assess the knowledge, attitude, and practice (KAP) regarding pharmacovigilance among healthcare Personnel working at a teaching institute’s hospital. Materials and Methods: Across-sectional study was conducted using a pre-designed, semi-structured pre-tested questionnaire based KAP study was carried out among healthcare Personnel after approval from Institutional Ethics Committee. Result: A total of 560 participants participated and filled up questionnaires. 97.10% of participants knew about pharmacovigilance and 94.50% of participants knew how to fill out the ADR form. Resident doctors’ knowledge was found higher compared to nursing staff while undergraduate students’ knowledge was found higher compared to intern doctors. Significant difference in attitude was observed between different sub-groups of health care Personnel. 69.64% of participants reported the ADR to their superior or any authority and 95.40% encouraged patients to report any unusual symptoms or reactions they experienced with medications. However, there was a gap between identifying and reporting ADRs. Conclusion: Most healthcare Personnel knew about the concept of pharmacovigilance, the role of pharmacovigilance in post-marketing surveillance, the national pharmacovigilance centre or authority in a country, and also knew how to fill out the Suspected ADR form, but the practice of reporting ADR was relatively poor.

DOI: 10.5281/zenodo.

2. Therapeutic Approaches to Prevent Disease Recurrence in Uveitis
Nakka Suhasini
Abstract
Introduction: Uveitis, a leading cause of blindness, often causes complications like cataracts and glaucoma due to recurrent episodes. This prospective study aims to compare the efficacy of corticosteroids, immunosuppressants, and biologics in preventing uveitis recurrence, focusing on recurrence rates, visual acuity, and treatment-related complications to optimize therapeutic strategies. Methods: This prospective observational study, approved by the ethics committee, assessed the efficacy of systemic corticosteroids, immunosuppressive agents, and biologics in preventing uveitis recurrence. Patients aged 18-65 with non-infectious uveitis were included. Outcomes measured included recurrence rate, time to recurrence, visual acuity, and adverse effects over 12 months. Results: Biologic therapy demonstrated the lowest recurrence rate (20%) and longest time to recurrence (10.5 months), with significant visual acuity improvement (0.20 LogMAR; p = 0.03). Corticosteroids had the highest adverse effects (50%), particularly cataracts (20%). Biologics were the most effective and safest treatment for preventing uveitis recurrence. Conclusion: Biologic therapy is the most effective treatment for preventing uveitis recurrence, offering the lowest recurrence rates, the longest time to recurrence, and the greatest improvement in visual acuity. Additionally, it has the fewest adverse effects, making it a safer option compared to corticosteroids.

DOI: 10.5281/zenodo.

3. Morphometric Study of Sacral Hiatus: Anatomical Variability and Clinical Relevance
Anil B. Bobde, Pushpalata Rameshwar Selukar
Abstract
Background: The sacral hiatus, an essential anatomical structure located at the caudal end of the sacral canal, exhibits significant morphological and morphometric variability. These variations are crucial for clinical procedures such as caudal epidural anaesthesia. Understanding the anatomical variability of the sacral hiatus can help improve the success rate of regional anaesthesia and minimize procedural complications. Methods: A cross-sectional study was conducted on 40 dry human sacra obtained from medical colleges in the surrounding region. The shape, apex, and base location of the sacral hiatus were analysed, along with morphometric measurements including length, breadth, and anteroposterior diameter. All measurements were performed using Vernier calipers (accuracy 0.1 mm). The data were statistically analysed to determine mean, standard deviation, and frequency distribution. Results: The inverted U shape (50%) was the most common sacral hiatus shape, followed by inverted V (32.5%), irregular (15%), and dumbbell (2.5%). The apex of the hiatus was predominantly located at the 4th sacral vertebra (50%), with the base most commonly at the 5th sacral vertebra (60%). The mean length of the hiatus was 32.5 mm ± 9.8 mm, the breadth ranged from 8 mm to 22 mm (mean 15.4 mm ± 3.1 mm), and the anteroposterior diameter at the apex averaged 6.4 mm ± 1.3 mm. Conclusion: The study confirms significant anatomical variability in the sacral hiatus, which is clinically relevant for anesthesiologists and surgeons performing caudal epidural blocks and other sacral procedures. The findings highlight the need for careful pre-procedural anatomical assessment to improve procedural success rates and minimize complications.

DOI: 10.5281/zenodo.

Impact Factor: 2.921

NMC Approved Embase Indexed

This journal is peer Reviewed Journal