The aim of the research was to develop a formulation which has no or less side effects and toxicities, stably accumulates large amount of water, is excellent in cooling effect, offers water retaining for a long duration and has superior functionality e.g. reducing fever, migraine, headache, neuralgia. Methods
: Different formulations were formulated using different polymers like Xanthan gum, HPMC, Carbopol 934 NF, sodium CMC, Guar gum, Gelatin and Ultraze in different ratio. The formulations were evaluated for Physical Appearance, pH, Homogeneity, Viscosity, Consistency, Swelling studies, Loss on drying, Skin irritation test, Stability studies. Results:
was having good adhesive property and was very easy to apply on the non-woven fabric. The elasticity and viscosity were good and was clear in appearance. All the formulations were evaluated for various parameters and formulation C5
was most stable among all with good adhesive property, smooth and good elasticity with highest water absorbing capacity and highest cooling effect and this formulation was taken as optimized formulation. Conclusion:
From the present investigation it can be concluded that that C5
formulation showed optimum homogeneity, consistency, viscosity, swelling studies and stability. Cooling gel sheets could be a potential method for reducing fever in near future which can be replacements for the old method of applying wet cloth on the forehead. The cooling gel sheets could provide cooling for maximum 6-8 hrs with a single sheet.