Fast dissolving tablets (FDTs) are an advanced drug delivery system designed to disintegrate or dissolve rapidly in the mouth without the need for water. This innovative dosage form enhances patient compliance, especially for those who have difficulty swallowing conventional tablets. FDTs offer numerous advantages, including rapid onset of action, convenience, and improved bioavailability for certain drugs. This research provides evaluation of fast dissolving tablet of Zidovudine, various types of preformulation parameters like melting point, solubility study, compatibility study, DSC investigation and FTIR investigation of the drug as well as precompression evaluations for the powder blend such as angle of repose, bulk density, tapped density, compressibility index along with hausner’s ratio. Post compression parameters has been also evaluated like hardness, thickness, diameter, drug content, weight variation, friability, wetting time, disintegration, dissolution of fast dissolving tablets.

DOI: 10.5281/zenodo.

Background: Acute appendicitis is one of the most common surgical emergencies worldwide, often necessitating an appendicectomy, which can be performed via an open or laparoscopic approach. The laparoscopic appendicectomy has gained popularity due to its minimally invasive nature, offering benefits such as reduced postoperative pain, shorter hospital stays, and quicker return to normal activities. In cases of non-perforated appendicitis, where the appendix has not ruptured, the risk of postoperative complications like surgical site infections (SSIs) is generally lower compared to perforated cases. Approximately 30% of appendectomies are for complicated acute appendicitis (CAA). With laparoscopy, the main post-operative complication is deep abscesses (12% of cases of CAA, versus 4% for open surgery. Aim: The aim of this study is to determine whether the routine administration of postoperative antibiotics is necessary in preventing postoperative complications in patients with non-perforated appendicitis who undergo laparoscopic appendicectomy. Material and Method: A total of 120 patients with non-perforated appendicitis undergoing laparoscopic appendicectomy divided into two groups. Group B (n=60) patients received single dose of preoperative antibiotic and group A (n=60) patients received preoperative dose, as well as three postoperative doses of antibiotics. Patient demographics, comorbidities, preoperative antibiotic use, and operative details. Incidence of SSIs, other complications, hospital stay, readmission, and antibiotic-related adverse effects. Following laparoscopic appendicectomy, surgical wound was inspected after 48 h, 72 h, and on day 7 to look for any signs of postoperative SSI. Group B patients received a single dose of preoperative antibiotics and group A patients received the same regimen, in addition, antibiotics were administered 24 hours postoperatively. Patients of both groups were followed-up for 30 days to assess the postoperative infectious complications. Results: The mean age in group A was 22.24±6.29 years compared to 25.32±6.55years in group B. No significant difference was observed between the two groups regarding mean age, gender distribution, pain, fever, nausea/vomiting, Mc Burney’s tenderness, bowel sounds, total leukocyte count, ultra-sonography, diagnosis, and histopathology report.  The difference between both the groups for incidence of SSIs was statistically insignificant. Both groups comprised 120 patients, as well both groups were compared in baseline characteristics. Statistically, there was no significant difference in rates of SSIs between both groups. Conclusion: Single dose of preoperative antibiotics was sufficient in reducing SSIs after appendectomy for NPA. Depending on the results, the study could either support the continued use of postoperative antibiotics or suggest that they may be unnecessary in non-perforated appendicitis cases, potentially leading to changes in clinical practice guidelines. This study would provide valuable evidence to guide the management of postoperative care in laparoscopic appendicectomy for non-perforated appendicitis.

DOI: 10.5281/zenodo.

Background: Preeclampsia is a major global cause of morbidity and mortality among mothers and perinatals, especially in areas with limited resources. It has been suggested that low-dose aspirin can prevent preeclampsia, particularly in high-risk individuals. The purpose of this research is to determine whether low-dose aspirin can prevent preeclampsia in pregnant patients who are admitted to a tertiary care hospital in Kolkata. Aims: To determine the effectiveness of low dose aspirin in the prevention of preeclampsia in pregnant women with risk factors at Calcutta National Medical College and Hospital, Kolkata Methods: Our study was carried out at the Department of Obstetrics and Gynaecology of C.N.M.C&H, Kolkata after obtaining approval from the Institutional Ethical Committee. All patients who met the above mentioned criteria were included in the study. The study included 200 post-natal mothers with risk factors of preeclampsia were selected from the high risk ward of our hospital. They were divided into cases and controls each containing 100 subjects with the same risk factors. Results: In Cases, 84(84%) patients had not taken low dose aspirin and 16(16%) patients had Taken low dose aspirin. In Controls, 72(72%) patients had not taken low dose aspirin and 28(28%) patients had Taken low dose aspirin. Association of regular intake of low dose aspirin in their recent pregnancy with preeclampsia and intake of low dose aspirin was statistically significant (p=0.04052). In with FGR, 4 patients had Taken low dose aspirin and 40 patients had not taken low dose aspirin. In without FGR, 40 patients had Taken low dose aspirin and116 patients had not taken low dose aspirin. Association of FGR with preeclampsia and intake of low dose aspirin was statistically significant (p=0.02). Conclusion: The only effective treatment for preeclampsia, which is a major cause of maternal morbidity and mortality globally, is delivery of the fetus and placenta. There are various opportunities in the fields of improved risk classification, preventative measures, and treatments, and several innovations are on the horizon. When begun after 12 weeks of gestation in individuals with preeclampsia risk factors, low dose aspirin 75 mg once daily is very successful in reducing the risk of preeclampsia and improving the outcomes for both the mother and the fetus.

DOI: 10.5281/zenodo.