Memecylon edule (L.) is belongs to Melastomataceae family used in many folklore medicines. The present study was focused on different solvent (methanol, acetone, ethyl acetate, chloroform and hexane) leaf extracts of M. edule were evaluated for their antimicrobial potential and bioactive components (ethyl acetate extract) were analyzed by GC-MS. The antimicrobial activity was done by well in agar and disc diffusion methods against four fungal pathogens and 17 bacterial pathogens include 5 reference (MTCC) strains. `The results show all these extracts exhibited different degree of antimicrobial activity on tested organisms. Agar well diffusion method, contributed superior antimicrobial activity than disc diffusion method. The maximum antimicrobial activity was exhibited in ethyl acetate extract against Streptococcus pneumoniae (MTCC 655) (32 mm) with minimum inhibitory concentration (MIC) concentrations of 62.5 µg/ml and minimum bactericidal concentration (MBC) of 1 mg/ml with 5 CFU followed by acetone extract. In disc diffusion method, the ethyl acetate extract shows maximum antibacterial potential against S. pneumoniae (MTCC 655) (25 mm), Salmonella typhimurium 1 (MTCC 98) (25 mm) followed by acetone extract (against S. pneumoniae (MTCC 655) (22 mm), S. typhimurium 1 (MTCC 98) (22 mm)). Most of the tested extracts were show nil or least activity on fungal pathogens in both methods. The maximum antifungal activity was observed in ethyl acetate extract against Mucor racemosus (11 mm). The GC-MS profile of ethyl acetate extract of M. edule showed 26 major compounds (peaks) with different parentage of peak values. Among them, steric acid was predominant (20.19%) constituent. The results from this investigation encourage M. edule extracts may be used in treatment of diseases caused by pathogenic microorganisms.