International Journal of

Current Pharmaceutical Review and Research

ISSN: 0976 822X Peer Review Journal

doi prefix: 10.25258/ijpqa

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1.A REVIEW ON G-PROTEIN COUPLED RECEPTOR
Tibrewal Richa, Kharsyntiew Reynoldly, Dawood Farida, Sharma Archana
Abstract
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases and are also the target of approximately 34% of all modern medicinal drugs.
2. HISTORY & PREPARATIONS OF NANOPARTICLES
Tibrewal Richa, Mishra Kavi Shankar
Abstract
A nanoparticle (or nanopowder, or nanocluster, or nanocrystal) is a microscopic particle containing at least one dimension less than 100 Nm.4 Nanoparticles are particles between 1 and 100 nanometers (nm) in size, with the surrounding interfacial layer. Integral parts of nanoscale subject matter, all its properties are profoundly influenced by the interfacial layer. Usually, the interfacial layer is made up of ions, inorganic and organic molecules. Organic molecules that cover inorganic nanoparticles are known as stabilizers, ligands of capping and surface or passivating agents.  In nanotechnology, a particle is characterized as a small object that acts in terms of its transport and properties as a whole. Particles are additionally graded according to their diameter. Nanotechnology refers to the production and use of materials whose nanoscale components exist and, by definition, are up to 100 nm in size. Nanotechnology investigates both electrical, optical, and magnetic activity, and molecular and submolecular structural behavior. It has the ability to revolutionize a range of methods and procedures in medical and biotechnology to make them compact, simpler, safer, and easier to administer.
3. A REVIEW: ORAL DISPERSIBLE TABLETS
Monika Leel, Priya Singh, Mohit Sharma, Muskan Verma
Abstract
The oral route of drug administration is speculated as one of the most acceptable route for drug delivery. Recently the orally dispersible tablets have become the most desirable dosage forms especially for a special category of patients i.e. pediatric, geriatric, bedridden, mentally ill, and uncooperative patients. Quick disintegration, better patient compliance, enhanced bioavailability are some of the vital characteristics of orally dispersible tablets which makes it superior from other traditional dosage forms. It is the most prominent dosage form for the patients which face difficulty in swallowing other conventional dosage forms. Basically the oro-dispersible tablets are defined as novel solid dosage form that provide the rapid disintegration or dissolution of solid medicament to exhibit it as a solution or in suspension form before administration. Reportedly, there are numerous drug candidates, which have been successfully formulated as orally dispersible tablets and have resulted in satisfactory invitro as well as in-vivo results. By going through this review, a researcher can easily become familiar to this novel formulation, as this review gives an quick insight of the advantages, disadvantages, ideal characteristics, method of preparation, and evaluation parameters of the oral dispersible tablets.

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3. CORONA_COVID-19: INVOLVEMENT OF LOCAL PRACTITIONERS AND QUACKS IN IDENTIFICATION & TRACKING OF COVID-19 INFECTION IN COMMUNITY
Verma Mohit, Kumawat Mahima, Ashok Kumar Sharma
Abstract
Recently With whole world India is also facing Pandemic of CORONA Virus disease. Keeping the actions and measures taken by Government of India still COVID infection is not transmitted in its third stage- Stage of Community spread. When it happens it starts spreading among people and it show its lethal form with huge morbidity and mortality as India is second largest democratic population in world. The thought of third stage of transmission is more than lethal and worst, It may not be easily controlled.  In-order to prevent its third stage of transmission rigorous screening is require along with tracking of existing cases. In respect of Uttar Pradesh, largest state of India on population basis, having population more than Brazil and Indonesia if may happen large number of causalities will report. Uttar Pradesh have around 107 thousands of villages. Social Distancing and Lockdown is the biggest implemented way to prevent community from getting infection. At village set-ups where community is unable to reach public or private registered health facilities they prefer to go to local practitioner or quacks which resides within their reach. Here, the local Practitioner and quacks are use to identify the patients who are approach to them for general illment including Cold, Cough and Respiratory distress and related. A format is shared to all Local Practitioners and Quacks on which they update the information of suspected symptomatic cases, a block level supervisor will asked daily from local Practitioner and quacks about the symptomatic cases on daily basis. List of local Practitioner and quacks is obtained from marketing representatives by District Chief Medical Officer (CMO) than block wise list has been shared to Block Medical Officer further Block medical officer appoint around 10 supervisors and distribute their area to get update of suspected symptomatic cases on phone. At district and block level RRT (Rapid Response Team) will go to particular village/region/area and thermally screen the community, If any of suspected cases found this person will go for District Hospital for sample collection of RT-PCR further go to laboratory of Aligarh Medical college for test result.

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