International Journal of

Current Pharmaceutical Review and Research

ISSN: 0976 822X

Peer Review Journal

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1. IDENTIFICATION OF CELLULOLYTIC BACTERIA FROM THESOIL AND SCREENING OF ITS ENZYMATIC ACTIVITY
Sangeetha. D,Tharani. J, Ishwarya. R, Geetha.M and Sivasankari. C
Abstract
Cellulase synthesizing bacteria were identified from the five different sources of the soil viz., garden soil, forest soil, municipal waste soil, kitchen waste soil, mangrove soil. Soil samples wereaseptically collected from different areas of Chidambaram. Efficacy of cellolase production were screened with all the ten isolates of cellulolytic bacteria using CMC agar (Carboxymethylcellulose agar) plates. Among the ten isolates, CPG-3 and CPMW-7 isolates showed high cellulolytic activity. These efficient two strains were selected for further studies. This two strainswere further identified based on morphological and biochemical test. The promising isolates were confirmed by 16s rRNA sequence. The isolate CPG-3 was confirmed as Bacillus cereusand the isolate CPMW-7 was confirmed as Stenotrophomonas maltophilia. The cellulase assay was performed for the two efficient isolates. The maximum enzyme activity (4.2 U/ml) was observed in Bacillus cereus (CPG-3) isolate.

2. IMPACT OF COVID-19 ON ENDOSCOPIC DEMOGRAPHY: A CROSS SECTIONAL STUDY
Yellapu Radha Krishna, Pentakota Kiranmayi, Mullapudi Harini
Abstract
Background: Pandemics are never easy to deal with, especially this new covid pandemic which has exposed the vulnerability and multiple lacunae in our existing health care. In this midst of chaos and uncertainty delivering endoscopic services had become a nightmare, as endoscopy is a procedure done in the aero digestive tract and also an aerosol generating procedure. This led to a lot of enigma and skepticism in selection of patients and precautions to be taken while performing procedures. Objective: To Know the Feasibility and Utility of endoscopy as diagnostic and therapeutic services in Covid pandemic in the midst of chaos and uncertainties. Materials and Methods: It is a retrospective study conducted from May 2020 to December 2020 in a Tertiary care Gastro hospital. Patients were screened clinically by Questionnaire highlighting the travel history, contact history, and residing history (hot spots for covid). X-Ray, HRCT and RT-PCR was done to exclude high risk cases. Clinical screening for symptoms, Vitals, Spo2 was done on all the patients. The procedures were performed using standard endoscopy equipment with appropriate COVID 19 protocols. Results: One thousand two hundred and eighty (1280) patients aged between 20 years to > 70 years were referred and undertake upper and lower GI endoscopy in a Tertiary Care gastro hospital. Majority of the cases who underwent endoscopy were in the age group 31-40 years 317 (24.8%). They comprised of 59.9% males and 40.1% females. Common endoscopic diagnoses were Gastric erosions 31.4% followed by Normal Upper gastrointestinal endoscopy (UGIE) / Lax Gastroesophageal (GE) Junction 17.4%. The most common symptom was dyspepsia seen in 725 (56.6%) of the patients, followed by dysphagia in 92 (7.2%), abdominal discomfort 64 (5%). Conclusions: This study highlights, with proper history and clinical screening and appropriate precautions it was possible to provide endoscopy service to the needy without a strict protocol and expensive pre-endoscopy work up like HRCT and RT-PCR for all patients, without compromising patient or staff safety. Patients with alarm symptoms like Dysphagia and GI Bleed benefited the most, many patients with functional GI Disorders also were reassured with negative endoscopy and counseling. As during these times, people were in panic mode with all negative things happening around; many of these functional patients with overlap anxiety disorders were scared to death. A positive diagnosis is very important while managing most of these GI disorders.

3. INSIGHTS ON IDENTIFICATION OF BIOSIMILAR DRUGS USING VARIOUS ANALYTICAL TECHNIQUES
Swetha Sri, G. Srija, K. Bhavya Sri, M. Sumakanth
Abstract
A biosimilar drug is a biological product that is approved based on demonstrating very similar to an approved biological product, known as reference biologic, for which there are no clinically meaningful differences in terms of safety, potency and purity. Biosimilar drugs have the potential to enhance treatment accessibility. They have the same strength and dosage as that of the reference product. The analytical biosimilar studies are conducted to demonstrate a highly similar profile concerning variations in biosimilar product’s critical quality attributes (CQAs). To achieve a successful approval of a biosimilar drug, establishing analytical and clinical biosimilarity is required. Approximately 90-95 drugs have gained approval so far in our country where studies are prevalent to increase the number and be handy for available to all classes of population. Byooviz(ranibizumab) having lucentis as its reference product was approved in the year sep 2021, whereas semglee(Insulin glargine)got its entry into the market in July 2021.The “Purple book” contains information including online database about FDA-licensed biological products which are regulated by CDER and CBER.Various chromatographic and spectroscopic techniques are used for biosimilar assessment which includes mass spectroscopy, reversed-phase chromatography, ion exchange chromatography, hydrophobic chromatography, hydrophilic interaction liquid chromatography, size exclusion chromatography, x-ray crystallography, multidimensional NMR spectroscopy, FTIR, fluorescence spectroscopy and also hyphenated techniques such as 2D-LC/MS, HILIC/MS.

4. ESTIMATION OF FERRITIN IN DIFFERENTIAL URBAN–RURAL FEMALE ASSOCIATION- A CROSS-SECTIONAL STUDY
Maheswari Reddy, Saba Shafeen, Chinmaya Keshari Sahoo
Abstract
Iron stores in the body exist primarily in the form of ferritin.  Iron deficiency Anaemia is the state where iron level is below normal, low transferrin saturation and ferritin as well as high iron binding capacity. The aim of this study is to find out pervasiveness of iron deficiency anaemia in teenage (10-16 years) female students living in Rural and Urban areas Moinabad village, Ranga Reddy District, India. A Total 150 teenage female students were randomly chosen from different Government Schools. The evaluation of Body Mass Index (BMI), haemoglobin (Hb) and serum ferritin (SF) levels by using BMI standard formula Hemo-Cue Hb 201+ analyzer and ELISA method respectively. The mean of BMI, Hb and SF levels were observed at 17.21± 0.71, 10.93±0.91 and 36.86 ± 23.11 respectively from all female students. Iron Deficiency Anaemia was observed in 67.3% of students. Nutritious deficiency is the common cause of iron deficiency anaemia in female students.

5. ROLE OF GREEN TEA WITH APPLICATIONS, BENEFICIAL EFFECTS, ITS POTENTIAL HEALTH IMPLICATIONS AND ACTIVE CONSTITUENTS IN COSMETICS
Apeksha P. Motghare, Parimal P. Katolkar
Abstract
Tea is one of the most widely consumed beverages worldwide, and is available in various forms. As compared to other forms of tea, Green tea is richer in antioxidants. The health benefits of green tea for a wide variety of ailments, including different types of cancer, heart disease, and liver disease, were reported. Currently, tea extracts, due to their rich composition and various biological actions, play an important role among the dietary supplements and cosmetics. Green tea (GT) extracts contain polyphenols, known to be effective free radical scavengers, and other ingredients that could also provide benefits to the skin.

6. BIOLOGICAL IMPORTANCE OF THE INDOLE NUCLEUS IN RECENT YEARS: A COMPREHENSIVE REVIEW
Prabhakar W. Chavan, Prashant C. Hanamshetty, Nagabhushana M M, Thippeswamy A
Abstract
Indole nucleus showed clinical and biological applications. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple receptors helpful in developing new useful derivatives. Indole derivative possess various types of biological activities i.e., antiviral, anti-inflammatory, anti-cancer, anti-HIV, antioxidant, antimicrobial, anti-tubercular activities, etc. This review created interest among researchers to synthesize a variety of indole derivatives. Literature data revealed that the indole derivatives have exhibited diverse biological activities and also have immeasurable potential to be explored for newer therapeutic possibilities.

7. STANDARDIZATION OF DIFFERENT PLANT PARTS OF ADHATODA VASICA NEES. FOR VALIDATION OF IT’S QUALITY EVALUATION WITH SPECIAL EMPHASIS ON AYURVEDA
Deepthy Mohan, Indu Chandrabose, Ashi Augustine, V. Remya, N.S. Nidhi, G.R. Asish, Sheela Karalam
Abstract
Ayurveda system nearly using 90 percent of the Crude drugs is obtained from the plant sources. The drugs of plant origin especially of herbaceous nature are frequently used as whole plant; otherwise their parts such as root, stem, leaf, flower, seed, fruit, rhizomes, bark of a stem or root, wood, and their exudates or gums etc. Adhatoda vasica Nees. is an important drug used mainly in the Ayurvedic industry in their formulations. The present study deals with the application of analytical methods for to find out the variations with in different parts of a single plant by adopting pharmacognostical phytochemical and analytical parameters in Adhatoda vasica plant .Identified fresh materials of Adhatoda vasica categorized in to 5 type of samples according to different ratio of stem and root portions of plant material were documented.

8. COMPARATIVE PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITIES OF TRADITIONALLY USED CITRUS SPECIES: CITRUS LIMON, CITRUS AURANTIUM, CITRUS MEDICA
Ashok Kumar Sharma, Mukesh Sharma, Shankar Lal Soni, Charanjeet Singh, Dilip Agarwal, Sanwar Mal Yadav
Abstract
Plants are very rich and important source of various therapeutic compounds which are tremendiously using in pharmaceutical industry. Several studies confirmed that the presence of phytochemicals contribute medicinal as well as physiological properties to the plants. Citrus fruits, which belong to Rutaceae Family, accumulate a great variety of phytochemicals including low molecular phenolics, acetophenones, terpenoids, flavanoids, stilbenes and tannins. Citrus Limon, Citrus Aurantium, Citrus Medica possess antimicrobial, antibacterial and antioxidant properties or agents which boost up the individuals immune system. The traditional medicine practice is recommended strongly for citrus plants/ fruits and it is suggested that further work should be carried out to isolate the various active constituents responsible for therapeutic activity of such plants which belongs to Rutaceae family. In the present review, various materials and methodologies are studied and comparative analysis of phytochemicals and phytoconstituents such as alkaloids, carbohydrates, flavoinds, tannins, proteins etc. are screened of Citrus Limon, Citrus Aurantium, Citrus medica.

9. A REVIEW ON VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF MYCOPHENOLATE MOFETIL IN PURE AND PHARMACEUTICAL TABLET DOSAGE FORM
Mo. Firoj Tanwar, Ritika Bhatia, Sulekha Mandal, Dilip Agarwal
Abstract
Immunosuppressant medications, or those that weaken the body’s immunological response, such mycophenolate mofetil (CellCept) is used to treat a variety of autoimmune illnesses. The prevalence of normal phase chromatography in HPLC has dwindled as a result of its inefficiencies, such as the short solvent retention times for its mobile phase solvents. Consequently, liquid chromatography systems frequently use reverse phase chromatography. The goal of this study is to describe and create a straightforward, precise, and focused technique for the RP-HPLC method of mycophenolate mofetil determination in pure and pharmaceutical dosage form. The accuracy, system appropriateness, precision, linearity, robustness, limit detection and limit of quantitation are just a few of the factors that may be used to verify the RP-HPLC method.

10. A STUDY ON ADVERSE EFFECTS OF DRUGS DURING THE CLINICAL MANAGEMENT OF DIABETES
Khushboo, Yogesh Sharma
Abstract
Background: DM is one of the widely spread disorder in the world. In this disease the blood sugar level increases. The management of DM is done by several oral hypoglycemic drugs. In this study we are observing the adverse effects during the management of DM and produced due to the consumption of anti-diabetic drugs. After the completion of the study we will be able to know the outcome of the adverse effects. Aim & Objective: To observe the adverse drug reactions of drugs during the clinical management of the diabetes to overcome them and make life easy by safe use of drugs and balanced diet. Method: The patients were selected from O.P.D of Imperial Hospital & Research Center. Total 509 patients will be selected on the basis of different study criteria. Patient counseling process was carried out using specified forms taken them for analysis. Observation: Individuals of age 35-75 year, both sex and different type adverse effects were selected for present study. Initially total 550 patients were taken; out of 550 patients,  41 patients had discontinued the clinical trial due to selection criteria. Finally 509 patients were included. It was found that out of 509 patients 30% were below 50yr. male, 24% were below 50yr. females, 25% were above 50yr. male & 21% were above 50yr. females. It was found that out of 509 patients 75, 76, 84 & 132 patients of them were affected due to Dryness; Hair loss, Muscular & joint pain; Irregular breathing. Result & Conclusion: As per the anthropometric assessment showing in the table and chart, the multiple and combination therapy of drugs having multiple and highest peak of the adverse effects. The highest percentage of adverse effects were found with drugs  Metformin + Glimpride + Pioglitazone. The patients with Metformin + Glimpride + Pioglitazone were suffering from all the side effects as compared to other. The highest peak of patients found of the adverse effects were found with drug Metformin + Glipizide in male below 50 year old, where as in male above 50 year old found  highest peak of patients with drug Metformin + Glimpride + Pioglitazone. The minimum adverse effects were recorded with drug Metformin with minimum number of patients. The second minimum adverse effects were recorded with drug Glimpride. As per the above results we can conclude that the drug Pioglitazone having maximum adverse effects as compared to other drugs.

11. A NOVEL APPROACH IN GASTRO RETENTIVE DRUG DELIVERY SYSTEM: FLOATING DRUG DELIVERY SYSTEM
Priya, Dilip Agarwal, Mohit Khandelwal
Abstract
The purpose of writing this review on gastro retentive drug delivery systems was to compile the recent literature with special focus on various gastro retentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In this review, the current technological developments of FDDS and marketed products have been discussed. In addition, the pharmaceutical basis of their design, their advantages and future potential for oral controlled drug delivery are discussed.

 

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