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Volume 1, Issue 3, November 2010 – January 2011
1. Indole: A Versatile Nucleus in Pharmaceutical Field Srivastava, Anupam, Pandeya, S.N.
The indole nucleus is found to be very active nucleus in pharmacy field as several natural alkaloids having indole as their basic ring are found to be therapeutically active agents. In the recent years a lots of synthetic drugs have been synthesized & found to be promissing anticancer, antimicrobial, anticonvulsants, & antidiabetic agents. In the present review the several newer activities have been concluded as Liver x receptor (lxr) agonist, Tyrosin kinase inhibitor, Hepatoprotective, Antiviral, Melanotonin analogus etc.
2. Quantitative Estimation of Clobazam in Bulk drug and tablets R. K. Jat, R. C. Chhipa, S. Sharma
A sensitive and rapid extractive spectrophotometer method has been developed for the assay of clobazam in bulk drug and tablets. The method is based on the formation of a chloroform soluble ion-pair complex between clobazam and bromophenol blue in an acidic medium. The complex shows maximum absorbance at 413 nm. Beer’s law was obeyed in the concentration range of 5-25 μg /ml. Results of analysis were validated statistically and by recovery studies. The proposed method is now simple, new, reproducible, and accurate and successfully employed in routine analysis of clobazam bulk drug and tablet dosage forms.
3. Formulation, Development and Evaluation of floating tablet of Metformin Hydrochloride using optimization of gas generating agent. Gaur A and Shah H. P.
The present study deals with drug release enhancement of Metformin Hydrochloride using floating technology by optimization of gas generating agent to improve the buoyancy time. Metformin hydrochloride is a oral antihyperglycemic agent of biguanide class used in treatment of type 2 Diabetes. It is hydrophilic drug which absorbed slowly and not completely form the gastrointestinal tract. The absolute bioavailability is reported to be 50-60%. This technology uses direct compression method to prepare floating tablet of Metformin Hydrochloride with release retardant polymer HPMC K-100, PVP K-30, Carbopol 934p and different concentration of gas forming agents sodium bicarbonate and citric acid. The floating behavior and in vitro dissolution studies ware carried out. From the result final formulation release was found to be approximately 96% in 24 hr, while the floating lag time was observed to be 3 min and the tablet remained floatable throughout studies. Form the result of the study we conclude that incorporation of gas generating agent produced initial burst-effect due to production and release of CO2 form polymeric matrix. Increased concentration of sodium bicarbonate results in increased bursting effect. Optimum concentration of sodium bicarbonate was found to be 8-10% to produce low floating lag time. Thus, with using of optimum concentration of gas generating agent the floating tablet of Metformin Hydrochloride was successfully developed.
4. Phylogenetic relationship between Argemone mexicana and A. ochroleuca Monika Karnawat and C. P. Malik
Combined data based on morphology, cytology, cross ability and interspecific fertility are secured in Argemone mexicana and A,ochroleuca ssp ochroleuca and A.ochroleuca ssp stenopetla with an intent to understand their relationship. Distinct differences between the two species merit their separate species status. Argemone mexican is diploid with 14 bivalents and normal meiotic behavior whereas A.ochroleuca ssp. ochroleuca and A. ochroleuca ssp stenopetla ssp had 28 bivalents.