Volume10,Issue4

1. FORMULATION, DEVELOPMENT AND EVALUATION OF LULICONAZOE ORGANOGEL
Ashok Kumar Sharma, Pushpendra Singh Naruka, Shankar Soni, M.S. Ranawat, Mohit Khandelwal, Shaneza Aman
Abstract
The main aim of this study was to develop a topical drug delivery (Organogel) of Luliconazole to reduce the dose of the active drug, to improve patient compliance, to avoid the side effects and increase local onset absorption and action. Luliconazole is an optically active imidazole antifungal agent. It has been found to have broad-spectrum of antifungal activity against pathogenic fungi, especially dermatophytes. Methods: Topical Organogel formulations of Luliconazole were prepared using span-60 with different penetration enhancer with their different concentrations. Six different formulations of Luliconazole were prepared and evaluated with respect to their colour, Spreadability, viscosity parameter, determination of pH, drug content, in vitro drug release studies, zeta potential studies, and stability studies. Results: FT-IR study revealed that there were no any significant interaction between the drug, excipients and polymers. All the designed formulations of Luliconazole show acceptable standard physical properties. The drug content and percentage yield were higher for F2 formulation among all formulation F2 shows better drug release. Stability study of the best formulation F2 (Coconut oil) shows that there was no difference in drug content and in vitro drug release studies. Conclusion: From the above observation results that this F2 formulation (Coconut oil) may be more encouraging topical substitute for the healing of fungal infections in the skin.