Volume10,Issue3

1. DESIGN AND EVALUATION OF FAST DISSOLVING TABLET OF BECLOFEN BY USING NATURAL (FENUGREEK POWDER) SUPERDISINTEGRANT
Ashok Kumar Sharma, Pushpendra Singh Naruka, Shankar Soni, M.S. Ranawat, Mohit Khandelwal, Shaneza Aman
Abstract
The demands of new drug delivery system fast dissolving tablets have ever increased day by day during the last two/three decade. In the proposed research study, the effect of natural Superdisintegrants was compared with synthetic Superdisintegrants and other conventional Superdisintegrants in the formulation of fast dissolving tablet drug delivery system and formulation of Beclofen. Baclofen is a GABA agonist NSAID is used as a skeletal muscle relaxant and also used for the relief of painful and uncomfortable muscle spasms, joint stiffness caused with rheumatoid arthritis. In the present work 6 formulations of Fast dissolving tablet of Beclofen were prepared by using different type of Superdisintegrants was evaluated and compiles with the official parameters. Various formulations were prepared using four different- different superdisintegrsnts namely natural super disintegrats Fenugreek Powder, crespovidone, cross carmelose sodium with three effective concentrations (3%, 6%, and 9%) by direct compression method. Formulation F8 results the lowest disintegration time and in-vitro dissolution studies observed that formulation F8 showed 97.06% drug release at the end of 3 minutes.