1. Incidence of Microalbuminuria among Patients with Recent-Onset Type 2 Diabetes: A Study Based on Spot Urinary Albumin-to-Creatinine Ratio Analysis
Gupta Akhil, Gupta Shalini
Abstract
Microalbuminuria is an important predictor of renal and cardiovascular complications1 in patients with type 2 diabetes mellitus (T2DM). Early detection of microalbuminuria in recent-onset T2DM provides an opportunity to delay or prevent the progression to diabetic nephropathy and cardiovascular morbidity2. This study aims to determine the incidence of microalbuminuria in patients with recent-onset T2DM using spot urinary albumin-to-creatinine ratio (ACR) testing.
2. The Impact of Active Surveillance in Adverse Drug Reaction Monitoring: Institutional Observation
Manju Agrawal, Nalini Singh Chandra, Geetika Nayak, Usha Joshi, Vijay Babu Verma
Abstract
Background/Introduction: Adverse drug reactions (ADRs) are a significant challenge in pharmacovigilance, often underreported due to reliance on spontaneous reporting systems. Active surveillance provides a systematic approach to monitor and report ADRs, enhancing detection and reporting quality. This study assesses the impact of active surveillance on COVID-19 vaccine-related ADR reporting at a designated monitoring center.
Aim/Objective: To analyze the impact of active surveillance on the reporting of COVID-19 vaccine-related adverse drug reactions compared to passive surveillance.
Methodology: This retrospective observational study was conducted at the ADR monitoring center of Pt. JNM Medical College and Associated Dr. BRAM Hospital, Raipur, Chhattisgarh, under the Pharmacovigilance Program of India. The study included all adverse events following immunization (AEFIs) related to COVID-19 vaccination reported from January 10, 2021, to December 31, 2022. Data were collected through both passive and active surveillance methods. Active surveillance involved contacting beneficiaries via telephone within 7±3 days post-vaccination. All identified AEFIs were documented, analyzed, and compared for completeness and accuracy. Statistical analysis was performed using descriptive statistics, and results were presented in graphs and tables.
Results: During the study period, 94,294 doses of COVID-19 vaccines were administered, and 4,480 telephone calls were made to beneficiaries. A total of 685 ADRs were reported, with 353 (51.5%) related to COVID-19 vaccines. Of these, 334 (94.6%) were reported in 2021 and 19 (5.4%) in 2022. Active surveillance identified 312 (93.4%) AEFIs in 2021 and 8 (42.1%) in 2022, while passive surveillance accounted for 22 (6.6%) AEFIs in 2021 and 11 (57.9%) in 2022. Most AEFIs were associated with the first dose (91.5%), followed by the second dose (6.5%) and the third dose (2.0%). Gender distribution showed a higher reporting rate among females (53.75%) compared to males (44.31%).
Conclusion: Active surveillance significantly improved the detection and reporting of COVID-19 vaccine-related AEFIs compared to passive surveillance. The proactive approach facilitated timely identification of ADRs, contributing to enhanced patient safety and informed decision-making in pharmacovigilance.
3. Management of Anal Fissures Comparing Pharmaceutical and Surgical Approaches – A Systematic Review
Ravichandra Matcha, Suvarchala AKKIDAS, Lalithakumari Dumpala, Vamseepriya Yelisetti
Abstract
Anal fissures are a common yet distressing condition characterized by a painful linear tear in the anoderm, often leading to severe discomfort, bleeding, and altered bowel habits. Although acute fissures can resolve with conservative treatment, chronic fissures frequently require targeted intervention to break the cycle of pain, sphincter spasm, and ischemia.
The management of anal fissures primarily revolves around two approaches: pharmaceutical therapy aimed at reducing sphincter spasm and promoting healing, and surgical intervention, which remains the definitive treatment for refractory cases. Pharmaceutical options such as topical nitrates, calcium channel blockers, and botulinum toxin aim to relax the internal anal sphincter and enhance perfusion, whereas surgical options, particularly lateral internal sphincterotomy (LIS), directly relieve sphincter pressure, often providing long-term relief. However, concerns about postoperative complications, particularly fecal incontinence, continue to fuel debate over the ideal management strategy.
This systematic review critically evaluates and compares pharmaceutical and surgical management of anal fissures by analyzing their efficacy, recurrence rates, side effects, and patient satisfaction. By examining the latest evidence, we aim to provide clarity on the optimal treatment approach, balancing effectiveness with safety to guide clinical decision-making. Anal fissures are small tears in the lining of the anal canal, often causing significant pain and bleeding during defecation. Management strategies for chronic anal fissures primarily include pharmaceutical interventions and surgical procedures, notably lateral internal sphincterotomy (LIS). This systematic review aims to compare the efficacy and safety of pharmaceutical treatments versus LIS in the management of chronic anal fissures.
4. Effect of Saroglitazar on Fibrosis-4 Score in Prediabetic Patients with Non-Alcoholic Fatty Liver Disease
Barka Saud Binmazi, Jyoti Bobde, Deepak Bhosle
Abstract
Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is closely linked to insulin resistance, obesity, and Type-2 Diabetes Mellitus. The progression of NAFLD from steatosis to Non-Alcoholic Steatohepatitis (NASH), and cirrhosis is a significant health concern. Prediabetes, characterized by elevated blood sugar levels, is often associated with an increased risk of developing NAFLD.
Objective: To assess the effect of Saroglitazar, a dual-activity PPAR-α/γ agent, on the Fibrosis-4 (FIB-4) score and safety in prediabetic patients with NAFLD, highlighting the score’s cost-effectiveness and accessibility compared to invasive diagnostic methods.
Methods: This six-month prospective, single-center, observational study was conducted at the Department of Pharmacology, MGM Medical College, Aurangabad. It included 65 prediabetic individuals with NAFLD, confirmed by ultrasonography. Patients were administered 4 mg of Saroglitazar once daily. The FIB-4 score was calculated at baseline, 3 months, and 6 months to assess the effectiveness of the treatment.
Results: The study included 65 participants (41 males, 24 females) with a mean age of 54.4±7.83 years. The baseline FIB-4 score was 2.132 ± 0.34. A statistically significant reduction in FIB-4 scores was observed at 3 months (1.723 ± 0.27) and 6 months (1.514 ± 0.24). Adverse events were minimal, with only two patients reporting nausea and gastrointestinal upset.
Conclusion: Saroglitazar significantly reduced the FIB-4 score in prediabetic patients with NAFLD over a 6-month period, indicating an improvement in liver health. The treatment was well-tolerated with minimal adverse events. This study supports the potential of Saroglitazar as a non-invasive, effective treatment option for NAFLD in prediabetic individuals, particularly in resource-constrained settings like India.
5. The Doppler Study on Umbilical and Fetal Middle Cerebral Artery in Second and Third Trimester of Pregnancy in Evaluation of Intrauterine Growth Retardation
Twinkle Rameshbhai Vasava, Dharmesh Baria, Anil Rathva, Deepak Bhimani, Maoulik Modi
Abstract
Introduction: Intrauterine growth restriction (IUGR) is a major obstetric concern, contributing to increased perinatal morbidity, mortality, and long-term neurodevelopmental impairment. Identifying growth-restricted fetuses and implementing timely interventions is a critical aspect of antenatal care. While ultrasonography is useful for fetal growth assessment, Doppler velocimetry provides a non-invasive means of evaluating feto-placental circulation, offering crucial insights into fetal hemodynamic status. This study evaluates the utility of umbilical artery and middle cerebral artery (MCA) Doppler indices in predicting IUGR and adverse perinatal outcomes.
Materials and Methodology: A prospective observational study was conducted over eight months on 120 antenatal women with clinically suspected IUGR in the second and third trimesters. Doppler ultrasonography was performed to assess umbilical artery pulsatility index (PI), MCA PI, and cerebroplacental ratio (CPR). The correlation between these Doppler parameters and perinatal outcomes, including birth weight and NICU admission, was analyzed. Statistical significance was determined using chi-square tests.
Results: Umbilical artery PI exhibited the highest sensitivity (81%) for predicting IUGR, while CPR demonstrated the highest specificity (79%). Abnormal umbilical artery and MCA PI were significantly associated with low birth weight (p = 0.009, p = 0.017) and NICU admission (p = 0.021, p = 0.028). A reduced CPR was also strongly correlated with adverse perinatal outcomes (p = 0.006).
Conclusion: Doppler ultrasonography is a valuable tool for assessing fetal well-being in IUGR cases. Umbilical artery PI serves as a sensitive predictor, while CPR is highly specific for adverse outcomes. Integrating Doppler assessments into routine antenatal care can aid in timely interventions and improved perinatal outcomes.
6. Study of Outcome of Neonates in Premature Rupture of Membrane
Naikey Minarey, Rajat Patidar, Siddharth Jain
Abstract
Objectives: To study the outcome and risk factors in neonates of premature rupture of membranes delivery and to study the mortality and morbidity in neonates caused by premature rupture of membranes due to such causes as early onset sepsis, asphyxia, respiratory distress, preterm born, lbw.
Methods: The methodology for this study was conducted at the Index Medical College and Hospital in Indore, Madhya Pradesh, from January 2018 to June 2019. From January 2018 to June 2019, all 105 newborns who were admitted to the hospital with symptoms of respiratory distress syndrome, early onset sepsis, pneumonia, and low birth weight were included in the study. A comprehensive checklist was utilized to gather demographic information about both the neonates and their mothers during the data collection process. Neonatal information included preterm, rds, birth asphyxia, neonatal sepsis, pneumonia, neonatal jaundice, seizure, hospitalization in Nicu.
Results: most of the babies that were delivered were girls (57.1%), while 42.9% were boys. The ratio of males to females in the study was approximately 2:1. 33. Most common illness associated with mother was iron deficiency anemia (15. 2%) followed by megaloblastic anemia (7.6%), oligohydramnios in (5.7%), diabetes oligohydramnios in 4.8%. Among the 105 newborns, 60 (60%) tested positive for sepsis, while among the 105 mothers, 38. 1% tested positive.
Conclusion: PROM is a significant factor contributing to neonatal mortality. Maternal health conditions linked to prom were iron deficiency anemia, megaloblastic anemia, diabetes, and oligohydramnios. A substantial number of mothers and newborns tested positive for sepsis. Neonatal morbidities and mortality, including jaundice, seizures, fever, and pneumonia, were significant issues, with one-third of neonates experiencing these complications.
7. Clinicopathological Study of Thrombocytopenia in a Tertiary Care Hospital
Swetha M, Prasanthi C, Sanjana N
Abstract
Background: Thrombocytopenia is a commonly encountered hematologic condition necessitating a comprehensive assessment to ascertain its underlying etiology. The aim was to study platelet parameters and their correlation with clinical findings, other laboratory tests, and causes of thrombocytopenia.
Material and Method: This was a descriptive cross-sectional study conducted in the Department of Pathology at GITAM Institute of Medical Sciences and Research, Visakhapatnam for a period of one and a half years from September 29, 2022, to March 28, 2024. Patients with a platelet count of less than 150,000/µL were included in the study.
Results: A total of 308 thrombocytopenia cases were analyzed in this study. The most common age group with thrombocytopenia was between 20 and 40 years (51.6%). The male-to-female ratio is 1.6:1. Most patients (37%) had platelet counts ranging from >75,000-150,000/cu mm (Grade 1). Of the 308 cases, 62% had high Mean Platelet Volume, and 64% had high Platelet Distribution Width. We encountered 98% of cases with fever. Dengue was the most common cause of thrombocytopenia (64.5%), followed by viral fever (25%), malaria (6.1%), chronic liver disease (CLD) (3.5%), idiopathic thrombocytopenic purpura (ITP) (0.6%), and acute leukemia (0.3%).
Conclusion: Infectious diseases are the leading cause of thrombocytopenia, with dengue being the most common, followed by viral fever and malaria. Evaluating platelet counts and related indices is essential for the early diagnosis and treatment of medical conditions.
8. A Comparative Study of Conventional Uterine Curettage and Manual Vacuum Aspiration for Endometrial Sampling in Women with Suspected Endometrial Pathology Presenting with Abnormal Uterine Bleeding
Sumit Roy, Bibekananda Das, Debobroto Roy, Oindrila Mondal, Shachi Srivastava, Bibek Mohan Rakshit
Abstract
Endometrial sampling is a crucial diagnostic procedure for women with suspected endometrial pathology presenting with abnormal uterine bleeding (AUB). Conventional uterine curettage (CUC) and manual vacuum aspiration (MVA) are two common methods used for endometrial sampling. This study aimed to compare the efficacy, safety, and patient satisfaction of CUC and MVA for endometrial sampling in women with suspected endometrial pathology presenting with AUB. A prospective, randomized controlled trial was conducted at a tertiary care hospital, involving 100 women with suspected endometrial pathology. The results showed that MVA was superior to CUC in terms of efficacy, safety, and patient satisfaction. MVA had a higher success rate (96% vs. 82%), lower complication rate (4% vs. 18%), and higher patient satisfaction rate (92% vs. 76%) compared to CUC.
9. An Evaluation of two doses of Dexmedetomidine as an Adjunct to Bupivacaine in Ultrasound Guided Transversus Abdominis Plane Block for Postoperative Analgesia in Unilateral Inguinal Hernioplasty
Aditi Mishra, R. P. Kaushal, Vikas Kumar Gupta, Jyotsna Kubre, Preeti Lakra
Abstract
Background: Inguinal hernioplasty is a frequently performed surgical procedure associated with moderate to severe postoperative pain. Effective postoperative analgesia is essential to prevent adverse outcomes. The ultrasound-guided transversus abdominis plane (TAP) block targets the anterolateral abdominal wall’s innervation from T6-L1, which can enhance analgesia duration, delay the first analgesic request, lower overall analgesic consumption, and reduce opioid-related side effects. Adjuvants like dexmedetomidine, clonidine, dexamethasone, and fentanyl are often used to prolong the effects of bupivacaine. This study evaluated the addition of two doses of dexmedetomidine (0.5 mcg/kg and 1 mcg/kg) to bupivacaine for the TAP block, with the objective of determining which dose provides optimal postoperative analgesia.
Aims and Objectives: Aim of the study is to evaluate two doses of dexmedetomidine(0.5mcg/kg and 1 mcg/kg) in ultrasound guided transversus abdominis plane block for postoperative analgesia in patients undergoing unilateral inguinal hernioplasty. Primary objective was to identify optimal doses of dexmedetomidine added to bupivacaine for postoperative analgesia in unilateral inguinal hernioplasty while secondary objectives were to observe the time and average dose of rescue analgesics , level of sedation and other adverse effects related to drugs and technique, if any.
Materials and Methods: A prospective hospital based study was conducted at Gandhi Medical College , Bhopal comprising of 80 patients between age group 18-60 years , male, belonging to ASA grade I to II, scheduled for elective unilateral inguinal hernioplasty under the subarachnoid block (SAB) after informed consent. GROUP 1- 40 patients received a unilateral TAP block using 22 ml solution— consisting of 20 ml 0.25% bupivacaine and 0.5 mcg/kg dexmedetomidine dissolved in 2 ml normal saline. GROUP 2 – 40 patients received a unilateral TAP block using 22 ml solution— consisting of 20 ml 0.25% bupivacaine and 1 mcg/kg dexmedetomidine dissolved in 2 ml normal saline. Diclofenac 75mg was used as rescue analgesia. Post operative pain is evaluated by VAS score for pain at 0,2,4,8,12 and 24 hrs postoperatively, time to 1st request of analgesia ,total analgesia sedation by ramsay sedation score and any complications were noted.
Result: There was no statistical significant difference between the two groups in demographic characteristics (age, weight, side of surgery, duration of surgery, ASA), Group A consistently exhibited higher mean pulse rates and systolic blood pressure compared to Group B at various postoperative intervals especially at 1 and 2 hrs, with statistically significant differences. However, diastolic blood pressure and mean arterial pressure showed significant differences only at specific time points(1 and 2 hrs) postoperatively, with no significant variances at other intervals. Group A had lower VAS scores at rest and during coughing compared to Group B postoperatively at all time points, indicating better analgesia quality in Group B. Group B showed a longer mean time to first rescue analgesic (11.45 hours)compared to Group A (6.53 hours), indicating more effective pain management in Group B. Additionally, Group B had significantly lower total analgesic consumption in 24 hours (159.38 mg) compared to Group A (270 mg), suggesting better pain management efficacy or patient response in Group B. all 80 patients exhibited a Ramsay Sedation Score of 2. Only 5.0% of patients in Group B experienced bradycardia, which was successfully managed with atropine. Notably, neither group reported any instances of nausea, vomiting, or hypotension.
Conclusion: This study elucidated that addition of 1 mcg/kg Dexmedetomidine to Bupivacaine in ultrasound guided TAP block for postoperative analgesia in unilateral inguinal hernioplasty gives better quality and longer duration of post- operative analgesia than 0.5 mcg/kg Dexmedetomidine. It provides longer first analgesia request time and lesser total analgesia consumption in 24 hours with minimal side effects like sedation, bradycardia, nausea and vomiting.
10. Seroprevalence and Genotypic Analysis of Hepatitis C Virus: Correlation with Liver Function Markers in Hemodialysis Patients
Pavithraa Suresh, Pooja Nair, Anitha Magesh, Ribu G Hali, Anitha Roy, Royapuram Veeraragavan Geetha
Abstract
Background: Hepatitis C virus (HCV) remains a critical public health issue, especially among haemodialysis patients who are at higher risk of infection due to prolonged vascular access. The virus, a positive-sense RNA virus from the
Flaviviridae family, can lead to chronic liver disease and complications if not detected and treated promptly.
Aim: This study aimed to determine the seroprevalence of HCV among haemodialysis patients at a tertiary care center, analyze liver function parameters, and evaluate the correlation between HCV infection and patient demographics using statistical analysis.
Methods: A prospective study was conducted between June and August 2021 at Department of Microbiology, Saveetha Medical College and Hospital, Chennai, India. A total of 86 haemodialysis patients were screened for anti-HCV antibodies using Chemiluminescence Immunoassay (CLIA). Positive samples were further confirmed using Real-Time Polymerase Chain Reaction (RT-PCR) to detect viral RNA and determine genotype distribution. Liver function tests (SGOT, SGPT, total bilirubin, and direct bilirubin) were assessed, and statistical significance was determined using appropriate tests (p-value <0.05).
Results: Among the 86 patients, 11 (12.8%) were seropositive for HCV antibodies, of which 9 (81.8%) were confirmed positive by RT-PCR. Additionally, 16 (21.3%) seronegative patients tested positive for HCV RNA, emphasizing the limitation of antibody screening. The overall prevalence of HCV among haemodialysis patients was 29.1%. Elevated liver markers were observed in HCV-positive patients compared to seronegative individuals: SGOT (mean 68.4 ± 12.5 IU/L vs. 42.7 ± 8.9 IU/L, p = 0.002), SGPT (mean 72.3 ± 14.2 IU/L vs. 45.6 ± 9.3 IU/L, p = 0.001), total bilirubin (mean 1.8 ± 0.4 mg/dL vs. 1.0 ± 0.2 mg/dL, p = 0.003), and direct bilirubin (mean 0.9 ± 0.2 mg/dL vs. 0.5 ± 0.1 mg/dL, p = 0.004). Genotype analysis revealed genotype 3 as the most prevalent (62%), followed by genotype 1 (38%).
Conclusion: The study highlights a high burden of HCV among haemodialysis patients, emphasizing the urgent need for routine screening using more sensitive methods such as RT-PCR. Infection control measures, including stringent sterilization protocols, staff education, and patient awareness programs, are critical in reducing the nosocomial transmission of HCV in dialysis centers. The findings call for policymakers to strengthen healthcare policies to ensure better diagnostic facilities and treatment options for high-risk groups.
11. Role of Inflammatory Markers with Special Reference to Serum Ferritin and IL-6 Levels in COVID-19 Patients at a Tertiary Care Centre
Mythri G, Anil Kumar H, Sahana Y, Puneeth Nagendra, Prashanth Kumar M
Abstract
Background: The COVID-19 pandemic has highlighted the significance of inflammatory markers in assessing disease severity and guiding clinical management. Among these, serum ferritin and interleukin-6 (IL-6) have emerged as key indicators of hyper inflammation and disease progression. This study evaluates the role of these markers in COVID-19 patients at a tertiary care centre.
Objectives: This study aims to study the role of inflammatory markers with special reference to Serum Ferritin and IL-6 in COVID 19 patients in a tertiary care centre and to determine whether the associated factors correlate with the severity of COVID-19 disease.
Materials and Methods: An observational cross-sectional study was conducted at a tertiary care centre, analysing 135 COVID-19 patients admitted. Patients were categorized into mild, moderate, and severe cases based on clinical and laboratory parameters as per ICMR guidelines. Serum ferritin, IL-6, CRP, D-dimer levels and LDH were measured at admission and correlated with disease severity, inflammatory response, and patient outcomes. Statistical analysis was performed using SPSS software, with significance set at p<0.05. To evaluate the diagnostic accuracy of IL-6 and ferritin in predicting disease severity, receiver operating characteristic (ROC) curves were generated.
Results: Serum ferritin levels were significantly higher in moderate to severe cases compared to mild cases (p<0.01). IL-6 levels strongly correlated with disease severity (p<0.001). Ferritin demonstrated a higher AUC compared to IL-6, suggesting it may be a more reliable biomarker for disease severity in COVID-19 patients. However, both markers exhibited significant potential in distinguishing severe cases from mild/moderate ones.
Conclusion: Serum ferritin and IL-6 levels serve as important biomarkers for assessing COVID-19 severity. Routine measurement of these markers in clinical settings can facilitate early risk stratification and guide therapeutic decisions. Future research should focus on targeted interventions to modulate these inflammatory responses and improve patient outcomes.
12. Enhancing the Yo-Yo Intermittent Recovery Test Scores through Sprint Interval Training amongst Cricket Players
Imran Haroon Mohammad, Syeda Afroz Fatima
Abstract
Introduction: The young cricket players who have ambitions of playing at the national or international level or various leagues need to maintain high fitness levels regarding the Yo-Yo intermittent recovery (IR) test scores. Sprint interval training which consists of short duration high-intensity exercise for few sessions per week is a time-efficient protocol for improving the aerobic capacity and repeated sprint ability. Present study was undertaken to assess the effect of sprint interval training on the Yo-Yo intermittent recovery (IR) test scores in club level cricket players and also to compare the YYIT scores with VO2max scores.
Material and Method: The present study is a Randomised Controlled Trial was conducted on male cricket players aged 18 to 30 years playing more than 5 years of club level cricket. Study was conducted at a tertiary care hospital during year 2018-2020.
Results: In this study 18 subjects (9 in each group) were enrolled to take care of loss to follow up. In the sprint interval training group, the YYIT score improved from 14.73 ±0.71 level to 15.61±0.48 level. There was a statistical significant difference (p= 0.0005) after the intervention period of 8 weeks in the YYIT score in this group. Similarly, the VO2max values (ml/kg/min) improved from 46.0±4.48 level to 51.41±3.25 level. This was a statistical significant difference (p= 0.0018) after the intervention period of 8 weeks in the VO2max in this group. The YYIT score was 0.1±0.22 in the regular training group, and 0.88±0.46 in the sprint interval training group. This difference was also statistically significant with p value of 0.0003. Thus, sprint interval training improved the YYIT score significantly as compared to the regular training.
Conclusion: There was a significant improvement in YoYo intermittent test scores and aerobic capacity with the addition of sprint interval training of 10 minutes thrice a week. So, the study results are encouraging and we recommend that the protocol should be used for all the players at the cricket academies.
13. Experience of Using Valprote and Lamotrigine Combination in Resistant Epilepsy
Makarand M. Kanjalkar, Meenakshi Bhattacharya
Abstract
Introduction: Epilepsy is a neurological condition characterized by recurrent seizures, impacting a considerable number of individuals and leading to substantial morbidity, mortality, as well as economic and social challenges.
Objective: To evaluate the efficacy and safety of valproate and lamotrigine combination therapy in patients with resistant epilepsy.
Method: A Prospective observational study was conducted during January 2022 to December 2023 at Department of General Medicine, Government Medical College and Hospital, Chh. Sambhajinagar, Maharashtra, India of 43 patients of resist any epilepsy with a mean age of 28.44 years.
Results: Male 65.1% patients were predominant than female patients 34.9%. Out of 43 epilepsy patients, majority of patients i.e. 32.6% of patient’s observed excellent outcome, followed by 30.2% of patients were observed good outcome and fair outcome in 23.2% of patients and 13.9% of patient’s outcome was poor. None of our patient reported any adverse effect.
Conclusion: This study extends previous evidence that Valproate and lamotrigine can be safely combined show a favorable therapeutic interaction in patients with resistant epilepsy.
14. Role of Labyrinthine Sedatives in the Treatment of Residual Dizziness after Successful Epley Maneuver
Manasa D, Priya Ramesh Nair, Vinay S Bhat
Abstract
Background: Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo. In that posterior canal BPPV is the most common compared to horizontal canal BPPV and superior canal BPPV respectively. Residual dizziness is a frequent condition of unknown origin that manifests as persistent disabling imbalance after successful canalith repositioning maneuvers for BPPV. This study evaluated the role of labyrinthine sedative, Meclizine hydrochloride in treating residual dizziness after successful canalith repositioning by Epley maneuver in posterior canal BPPV.
Objectives: Role of Meclizine hydrochloride, a labyrinthine sedative in treating residual dizziness after successful canalith repositioning by Epley maneuver in posterior canal BPPV.
Material and Methods: A total of 60 patients were included in the study. They were divided into two groups: 30 to group A which received Epleymaneuver with Meclizine and 30 to group B who received only Epleymanuever.
Results: Of the 60 patients, on Day 1, Day 2, Day 3 for both the groups, in group A, by the 3
rd day 25 patients had no symptoms and 2 had a mild handicap, 3 had severe handicap. In group B, by 3
rd day, 24 patients had no symptoms, 3 patients had a mild handicap, 2 patients had a moderate handicap, and 1 patient had a severe handicap. The p value between the two groups was more than 0.05 and it was statistically not significant.
Conclusion: Addition of labyrinthine sedative like meclizine after successful Epley maneuver does not seem to significantly improve the residual dizziness so it is advisable not to prescribe unnecessary medications after successful Epley maneuver.
15. Correlation of Biochemical Markers with Oxidative Stress in Type-II Diabetes Mellitus: A Case-Control Study
Ram Mohan Rao Jaja, Jaya Jain
Abstract
Background: Type-II Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, hyperglycemia, and β-cell dysfunction. Oxidative stress plays a significant role in diabetes pathogenesis and complications by promoting lipid peroxidation, DNA damage, and chronic inflammation. This study aims to investigate the correlation between biochemical markers and oxidative stress in T2DM patients compared to healthy individuals.
Methods: A case-control study was conducted at Index Medical College, Hospital, and Research Center, Indore, under Malwanchal University (2022–2024). The study included 100 T2DM patients (cases) and 100 age- and sex-matched healthy individuals (controls). Oxidative stress markers (Malondialdehyde [MDA], Superoxide Dismutase [SOD], Catalase [CAT], and Glutathione Peroxidase [GPx]) were measured using spectrophotometric assays. Glycemic and lipid parameters were assessed, and statistical analysis was performed using SPSS v25.0 (p < 0.05 considered significant).
Results: T2DM patients exhibited significantly higher MDA levels (4.5 ± 0.6 nmol/L) compared to controls (2.3 ± 0.4 nmol/L, p < 0.001). Antioxidant enzyme levels (SOD, CAT, GPx) were significantly reduced in cases (p < 0.001). MDA positively correlated with HbA1c (r = 0.62, p < 0.001), while SOD and CAT negatively correlated with fasting glucose (r = -0.58, p < 0.001).
Conclusion: Oxidative stress is significantly elevated in T2DM, as indicated by increased lipid peroxidation and decreased antioxidant defenses. Strong correlations between oxidative stress markers and glycemic control suggest that antioxidant-based interventions could mitigate diabetes complications. Further research should explore personalized antioxidant therapies for improved diabetes management.
16. A Study of Clinical, Etiological and Radiological Profile in Late Onset Seizures at Government Tertiary Care Hospital, Telangana
Muralikrishna Maddela, Neela Rajyalaxmi, Macherla Swapna, Rasapally Anusha
Abstract
Aim of the Study: To study the clinical profile of patients with new onset seizures after 40 years of age.
Material & Methods: A 100 cases of Clinical Etiological and radiological profile in late onset seizures patients admitted in the Department of General Medicine, Government Tertiary Care Hospital.
Results: In present study majority of the patients were lying in the age group of 50 – 60 Years of age which was 40%, followed by 40-50 years (34%) and 26% of the patients were found in the age group of more than 60 years of age.
Conclusion: Out of 100 cases, 56 patients (56%) had significant imaging findings pointing towards the diagnosis. So every patient with new onset seizures should undergo some form of imaging, CT- Plain/ contrast or MRI- Brain depending on the situation as part of evaluation. Smoking and Hypertension are most common risk factors for seizures. From the study, it is clear that most of the seizures in late adulthood are symptomatic (86%). So every care must be taken to evaluate the cause of new onset seizures in adults.
17. A Prospective Study of Port Site Complications in Laparoscopic Abdominal Surgeries at Osmania General Hospital, Hyderabad
Sudha Spandana Vaidyula, C. Prathyusha, Seggam Sindhura
Abstract
Background: Laparoscopic abdominal surgery, also known as minimally invasive surgery (MIS), has revolutionized the management of various abdominal conditions, offering benefits such as smaller incisions, reduced postoperative pain, shorter hospital stays, and faster recovery compared to traditional open surgeries. The widespread adoption of laparoscopic techniques for procedures like cholecystectomy, appendectomy, and hernia repair has significantly advanced surgical practice. Despite these advantages, laparoscopic surgery is not without risks, and port site complications are among the most common issues encountered postoperatively.
Aim of the Study: To study the incidence and clinical outcome of port site complications following elective laparoscopic abdominal surgeries.
Material & Methods: This study was a prospective observational study conducted to evaluate the incidence, types, and management of port site complications in patients undergoing laparoscopic abdominal surgeries. Total No. of 50 cases was done and the study was conducted at Osmania General Hospital, Hyderabad from January 2022 to June 2023 and was approved by the institutional ethics committee.
Results: The results of a prospective study conducted on 50 subjects undergoing various types of laparoscopic abdominal surgeries. The analysis focuses on the distribution of complications based on the type of surgery, the influence of port size and access technique, and the role of patient-specific factors such as age and BMI. By identifying and understanding the determinants of port site complications, this research aims to contribute valuable insights into the field of minimally invasive surgery and guide future surgical practices to achieve better patient outcomes.
Conclusion: Laparoscopic abdominal surgeries offer numerous advantages, the management of port site complications remains a significant challenge. Continued research efforts aimed at refining techniques, identifying risk factors, and developing effective prevention and management protocols are crucial to advancing patient care and enhancing outcomes in this evolving field of surgery.
18. Impact of Musculoskeletal Comorbidities on Quality of Life and Healthcare Costs in Diabetes Patients: A comparative Study from a Tertiary care hospital, India
Mukesh Kabra
Abstract
Introduction: Diabetes is a chronic condition with long-term complications and multisystem involvement. The prevalence of diabetes is increasing globally, posing a significant public health challenge. The coexistence of other comorbidities not only complicates disease management but also increases financial burdens and negatively impacts the quality of life. This study aims to evaluate the impact of musculoskeletal conditions on individuals with diabetes compared to those without the disease.
Materials and Methods: A comparative study was conducted in community medicine and medicine department at Swaminarayan Institute of Medical Sciences and Research, a tertiary-level hospital located in Kalol, Ahmedabad among patients visiting tertiary care hospital. The objective was to assess the prevalence of musculoskeletal disorders in individuals with and without diabetes. A total of 100 patients with diabetes and an equal number of non-diabetic individuals were sequentially enrolled.
Results: The prevalence of musculoskeletal comorbidities was significantly higher in individuals with diabetes (46.2%) compared to the non-diabetic group (25.1%). The overall odds ratio (OR) for musculoskeletal disorders was 2.5 times higher in diabetes patients than in those without diabetes. Specifically, the OR for rheumatoid arthritis, chronic back pain, and osteoarthritis was 3.6, 2.9, and 1.7, respectively. Additionally, diabetic patients with musculoskeletal comorbidities experienced a poorer quality of life and higher direct treatment costs compared to those without such conditions.
Conclusion: Musculoskeletal comorbidities are highly prevalent among individuals with diabetes, significantly affecting their quality of life and increasing treatment costs. Integrating musculoskeletal screening into routine diabetes complication assessments could facilitate early detection and timely intervention, ultimately improving patient outcomes.
19. Exploring the Impact of Tuberculosis-Related Stigma on Patients, Contacts, and Society: A Mixed-Methods Approach
Mukesh Kabra
Abstract
Objectives: This mixed-methods study aimed to explore the experiences of 62 participants diagnosed with tuberculosis (TB), 57 individuals with direct contact with TB patients, and 61 members of the general public regarding TB-related stigma.
Materials and Methods: The study used both qualitative and quantitative methods to understand TB stigma. A representative sample of 62 TB patients, 57 contacts, and 61 individuals from the general public was selected. Data were collected through structured questionnaires and in-depth interviews. Trends and patterns were analyzed using descriptive statistics and the Chi-Squared test.
Results: Over half of the TB patients reported internalized stigma, including feelings of shame and fear of being perceived as contagious or different. 68% expressed anticipated stigma, fearing discrimination and avoiding open discussion of their illness. 10% reported enacted stigma, citing a lack of respect from medical staff. Females were more likely than males to experience both anticipated stigma and avoidance of discussing the disease (p-value). There was no significant association between gender and respect from medical professionals (p-value = 0.172). Among contacts, 30% believed poverty caused TB, and 79% feared community infection risks. Most contacts viewed TB patients with compassion (63%) and were willing to associate with them (82%). Male contacts were more likely to fear infection risks (p-value < 0.001). Among the general public, 72% feared infection, and 28% believed poverty caused TB. Education levels and sociodemographic characteristics, including gender and economic status, were linked to stigmatization, with significant differences in the perception of TB patients.
Conclusion: The study highlights the persistent stigma surrounding TB, underlining the need for programs that reduce stigma, enhance public awareness of TB, and educate medical professionals to treat patients with respect. Public education on TB causes is essential to reduce stigma, and targeted interventions to support TB patients’ social integration are necessary.
20. A Comparative Study of Rocuronium and Cisatracurium – Effects on Hemodynamic Response and Intubation Conditions in Elective Surgeries
Kakileti Vani Subrahmaneyswari, Jalaja Praveena Badugu, Lakshmi Sakuntala Vattikuti, Dutta Akhila
Abstract
Introduction: Neuromuscular blocking agents (NMBAs) optimize intubation, reduce tissue trauma, and aid surgical relaxation. Rocuronium, a non-depolarizing aminosteroidal NMBA, provides rapid onset without histamine release. Cisatracurium, a potent benzylisoquinolinium, offers slower onset with Hoffman elimination. This study compares rocuronium and cisatracurium’s effects on hemodynamic stress during intubation.
Methods: This prospective, randomized, double-blind study compared rocuronium and cisatracurium in elective surgeries under general anesthesia. Patients were randomized into two groups and administered the respective muscle relaxants. Hemodynamic parameters and neuromuscular monitoring guided dosing and intubation. Post-surgery, residual blockade was reversed, and patients were transferred to recovery.
Results: The study included 60 participants, evenly divided between groups. Most (36.7%) were aged 31–40 years, with a male-to-female ratio of 0.93. Pre-intubation HR, SBP, DBP, and MAP showed no significant intergroup differences. Intubation duration was significantly shorter in group R. Post-intubation hemodynamic parameters showed no significant differences between groups.
Conclusion: Rocuronium and cisatracurium demonstrated comparable hemodynamic stability during intubation and surgery. Rocuronium provided a significantly shorter intubation duration, making it advantageous in situations requiring rapid airway management. Both agents are effective and safe for elective surgeries, with choice depending on clinical context and individual patient considerations.
21. Correlation of Platelet Indices with Severity of Sepsis Patients in ICU- A Prospective Observational Study
Hiranya Kumar Saharia, Oreyjeet Das, S. Vignesh
Abstract
One of the most common causes of morbidity and mortality in ICU patients is the condition of Sepsis, that possesses a constant challenge to the treating and/ or the critical care physician. In that scenario, use of a basic blood investigation such as Complete Blood Count (that includes the Platelet Indices) may play a pivotal role in early prediction of the course of sepsis. Thus, in this study we have studied the role that Platelet Indices have in predicting the severity of sepsis patients in ICU, so as to use them as a marker of sepsis in peripheral as well as tertiary centres.
Total 102 patients of both sexes were included in the study, out of which 32 patients (31.4%) succumbed to sepsis, whereas a larger portion of the cohort, comprising 70 patients (68.6%), demonstrated clinical improvement during their stay in the ICU. It was found that Platelet Count (PLT), Platelet to Large Cell Ratio (PLCR) and Platelecrit (PCT) tend to increase in patients who recover from sepsis and have a decreasing trend in those who ultimately succumb. Whereas, Platelet Distribution Width (PDW) and Mean Platelet Volume (MPV) behaved in the opposite way, as both of these indices increased in patients who ultimately died due to sepsis and decreased in cases of improved ones. Thus, it can be concluded that Platelet Indices do have a role in predicting sepsis and its severity and hence, these indices from a routine Complete Blood Count (CBC) may be used as markers for predicting the progression of Sepsis.
22. An Assessment of Knowledge, Attitude and Practice Related to the Communication Skills of Final-Year Medical Students
Hirapara H.N., Sondarva D.B., Amane H.S., Vaja N.
Abstract
Objective: Effective communication is a cornerstone of quality healthcare, with significant implications for patient satisfaction, diagnostic accuracy, and clinical outcomes. This study assesses the knowledge, attitudes, and practices (KAP) of final-year medical students regarding communication skills, aiming to identify areas for improvement in medical education.
Methods: A cross-sectional questionnaire-based survey was conducted at GMERS Medical College, Junagadh, involving 163 final-year MBBS students. The questionnaire, which was pre-validated and pilot-tested, assessed students’ knowledge of communication principles, attitudes towards patient-centered communication, and self-reported practices in clinical settings.
Results: The results show that students possess strong theoretical knowledge, particularly in active listening (96.9%) and the importance of clear communication (95.7%), with some gaps in understanding the role of empathy (84.4%) and trust in patient care (88%). Most students expressed confidence in their communication abilities (52.8% very confident), and a majority recognized the importance of empathy (75.5%) and active listening (87.1%) in patient care. However, self-reported practices revealed variability in applying these skills, with only 46.6% consistently engaging in small talk with patients and 60.1% practicing active listening frequently.
Conclusion: The study underscores the need for targeted interventions to bridge the gap between knowledge and practice, such as role-playing, feedback mechanisms, and simulation-based training. The findings suggest that enhancing communication skills training can better prepare students for patient-centered care, thereby improving healthcare outcomes.
23. Paroxysmal Nocturnal Hemoglobinuria: A Case Report and Review of Literature
Islam U, Dhotre S, Nath N, Namrata N, Banakar U
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by complement-mediated intravascular hemolysis, thrombosis, and bone marrow failure. It results from a somatic mutation in the PIG-A gene, leading to deficient synthesis of glycosylphosphatidylinositol (GPI) anchors and subsequent absence of GPI-linked proteins on hematopoietic cells. Clinically, PNH presents with hemolytic anemia, hemoglobinuria, and a heightened risk of thromboembolic complications. Diagnosis involves flow cytometry to detect populations of GPI-deficient blood cells, particularly CD55- and CD59-negative cells. Eculizumab, a monoclonal antibody targeting terminal complement activation, has transformed treatment outcomes by reducing hemolysis and preventing thrombosis. Despite these advancements, challenges persist in managing bone marrow failure and minimizing long-term complications.
24. Low Dose Mifepristone in the Management of Uterine Fibroids
Nath Piyalee, Nath Pranoy, Thapa Pranjit
Abstract
Background: Uterine fibroids are the most common benign smooth muscle tumors of the female reproductive system. It accounts for one-third of all gynecological hospital admissions and is the most common indication (making up approximately 40%) for hysterectomy in premenopausal women. Mifepristone (RU 486) effectively reduces menorrhagia and other fibroid-related symptoms, and its size.
Objectives: To study the effect of low dose Mifepristone for 3 months on improvement of fibroid related symptoms and its size.
Materials and Methods: This was a hospital-based prospective cross-sectional study which was conducted in the Department of Obstetrics and Gynecology in Silchar Medical College and Hospital, Assam. 246 women were enrolled and divided into two groups. Patients in Group 1 received Tab Tranexamic acid (500 mg) and Tab Mefenamic acid (500 mg) thrice daily during menstrual bleeding for a period of 3 months. Patients in Group 2 received Tab Mifepristone 25 mg daily for 3 months.
Results: Mean PBAC score reduced by 96.03%, Mean Numeric Pain Rating Scale Score for dysmenorrhea reduced by 82.87%, fibroid area reduced by 34% and hemoglobin concentration increased by 10% at 3 months in Group 2. These changes in Group 2 were found to be statistically significant (p<0.001) compared to Group 1.
Conclusion: Mifepristone has proven to be safe and effective as compared to treatment with tranexamic acid and mefenamic acid for management of uterine fibroids.
25. The Impacts of Elevated Blood Pressure on Heart Metabolism
Kashif Naem Siddiqqi, Sehar Mushtaq Kanyu, Javed Hussain Bhat, Mohd Abass Dar
Abstract
Hypertension, or elevated blood pressure, is a significant global health burden affecting over 1.28 billion individuals. It is a major risk factor for cardiovascular diseases such as heart failure, stroke, and coronary artery disease. While its hemodynamic effects, such as increased arterial stiffness and left ventricular hypertrophy, are widely studied, the impact of hypertension on heart metabolism is less understood but equally critical. Hypertension, a prevalent cardiovascular disorder, significantly impacts cardiac structure, function, and metabolism. The chronic elevation of blood pressure imposes a sustained increase in cardiac workload, leading to pathological changes such as left ventricular hypertrophy (LVH), myocardial fibrosis, and capillary rarefaction. These structural adaptations disrupt the heart’s ability to maintain metabolic efficiency and flexibility. This manuscript provides a comprehensive review of the mechanisms by which hypertension alters cardiac metabolism, highlighting its profound effects on substrate utilization, mitochondrial function, and energy homeostasis. A key metabolic hallmark of hypertensive hearts is a shift in substrate utilization from glucose oxidation to an overreliance on fatty acid oxidation (FAO). While FAO typically serves as the primary energy source for the heart, its upregulation in hypertensive conditions is inefficient, oxygen-intensive, and associated with the accumulation of toxic lipid intermediates, leading to lipotoxicity. Concurrently, glucose uptake and oxidation are impaired due to reduced activity of glucose transporters, insulin resistance, and dysregulated signaling pathways. This metabolic inflexibility exacerbates energy deficits and compromises cardiac performance. Mitochondrial dysfunction emerges as a central feature in hypertension-induced metabolic derangements. The overproduction of reactive oxygen species (ROS), mitochondrial DNA damage, and impaired oxidative phosphorylation disrupt ATP generation, creating a state of energy starvation. Dysregulation of key molecular pathways, including the AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors (PPARs), and mammalian target of rapamycin (mTOR), further impairs energy sensing, substrate utilization, and mitochondrial biogenesis. Additionally, neurohormonal activation—particularly the renin-angiotensin-aldosterone system (RAAS) and sympathetic overdrive—drives oxidative stress, inflammation, and maladaptive remodelling, further compounding the metabolic burden on the heart.
26. Role of Interventional Radiology in Post – Living Donor Liver Transplant Complication Management
Yadav Raj Kumar, Bansal Nikhil, Heera Ram, Mishra Hemant, Mehra Rakesh, Gabhane Neeshnat
Abstract
Aim of the Study: To evaluate the role of interventional radiology in post-living donor liver transplant complication management.
Material and Methods: This prospective study was undertaken in Interventional Radiology Department Of Mahatma Gandhi Medical College & Hospital, Jaipur from January 2023 to December 2024. Total 20 patients referred from Liver transplant department for management of post LDLT complications. All patients evaluated for complications on 128 slice optima GE CT scan and on Allura clarity XperFD Philips medical system.
Results: In our study complications of total 20 cases of post living donor transplant liver were managed, 18 male & 2 females with age range from 20 yrs. to 70 yrs. Complications including biliary stenosis 35%, hepatic vein stenosis 15%, portal vein stenosis 5%, hepatic artery stenosis 10%, hepatic artery thrombosis10%, biliary leakage 10%, cholangiolar abscess 10% and lymphatic leak 5%. We had seven cases of biliary stenosis, six were successfully treated with insertion of internal-external drain and stenting. We had three cases of hepatic venous occlusion, successfully treated with venoplasty and stenting, two cases of hepatic artery stenosis treated with angioplasty and stenting and two cases of hepatic artery thrombosis treated with catheter directed thrombolysis. One case of portal vein stenosis treated with portal venoplasty and stenting. Two cases of cholangiolar abscess with aspiration. Two cases of biliary leakage and one case of lymphatic leak treated with percutaneous pigtail insertion. Finally, in our study, we had 100% success rate in hepatic artery stenosis, portal vein stenosis and hepatic vein stenosis, 85% in biliary complications and 50% in hepatic artery thrombosis.
Conclusion: Interventional radiology plays a crucial role in management of post-LDLT complications. It offers a safe and effective alternative to surgery in terms of minimal invasiveness with faster recovery, targeted treatment for specific area without damaging surrounding tissues and lower morbidity with improved outcomes.
27. Comparison of Empagliflozin and Linagliptin in Glycaemic Control among Type 2 Diabetes Mellitus Patients
Raj Kumar Sharma, Amit Kumar Verma, Satyendra Narayan Tiwari
Abstract
Introduction: Type 2 Diabetes Mellitus (T2DM) is a progressive metabolic disorder requiring effective glycaemic control to prevent complications. Among newer pharmacological agents, sodium-glucose cotransporter-2 (SGLT-2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated efficacy. Empagliflozin, an SGLT-2 inhibitor, promotes urinary glucose excretion and offers cardiovascular benefits, whereas linagliptin, a DPP-4 inhibitor, enhances incretin-mediated insulin secretion. This study compares the efficacy and safety of empagliflozin and linagliptin in T2DM management.
Materials and Methods: This prospective, open-label, randomized controlled trial was conducted at Chirayu Medical College and Hospital, Bhopal, over 12 weeks. A total of 150 patients with T2DM were randomly assigned to receive empagliflozin (10 mg daily; n=75) or linagliptin (5 mg daily; n=75). Primary outcomes included changes in HbA1c, fasting plasma glucose (FPG), and postprandial glucose (PPG). Secondary outcomes included weight change, hypoglycemia incidence, urinary tract infections (UTIs), gastrointestinal side effects, and lipid profile changes. Statistical analysis was performed using SPSS version 26.0.
Results: Empagliflozin resulted in a significantly greater reduction in HbA1c (-1.2% vs. -0.9%, p=0.002), FPG (130.5 ± 18.7 mg/dL vs. 140.3 ± 20.2 mg/dL, p=0.01), and PPG (190.2 ± 25.6 mg/dL vs. 200.8 ± 28.4 mg/dL, p=0.03) compared to linagliptin. More patients in the empagliflozin group achieved HbA1c <7% (77.3% vs. 61.3%, p=0.04). Weight reduction was greater with empagliflozin (-2.1 ± 1.5 kg vs. -0.3 ± 1.1 kg, p<0.001). The incidence of hypoglycemia (6.7% vs. 10.7%, p=0.41) and UTIs (9.3% vs. 4.0%, p=0.21) were comparable.
Conclusion: Empagliflozin demonstrated superior glycaemic control and weight reduction compared to linagliptin without significantly increasing adverse events. These findings support the preferential use of empagliflozin in T2DM patients, particularly those requiring weight management.
28. Comparative Study of Insulin Glargine and Insulin Degludec in Patients with Uncontrolled Type 2 Diabetes Mellitus
Swati Kesharwani, Amit Kumar Verma, Raj Kumar Sharma
Abstract
Introduction: Type 2 Diabetes Mellitus (T2DM) is a progressive metabolic disorder requiring effective glycaemic control to prevent complications. While long-acting basal insulins such as insulin glargine and insulin degludec are widely used, their comparative efficacy and safety in patients with uncontrolled T2DM warrant further investigation. The objective of the study is to compare the glycaemic control, insulin requirements, incidence of hypoglycemia, weight changes, and quality of life outcomes between insulin glargine and insulin degludec in patients with uncontrolled T2DM over a 12-week period.
Materials and Methods: This prospective, randomized, comparative study was conducted at Chirayu Medical College and Hospital, Bhopal, from September 2023 to October 2024. A total of 150 patients with uncontrolled T2DM were randomized into two groups: insulin glargine (n=75) and insulin degludec (n=75). Primary outcome measured was the reduction in HbA1c levels after 12 weeks. Secondary outcomes included changes in fasting plasma glucose (FPG), daily insulin dose requirements, hypoglycaemic episodes, weight changes, and quality of life scores. Data were analyzed using SPSS version 26.
Results: Both groups showed significant HbA1c reduction, with insulin degludec (-1.45±0.9%) demonstrating a greater decline compared to insulin glargine (-1.09±0.8%), though not statistically significant (p=0.124). More patients in the insulin degludec group (69%) achieved HbA1c ≤7% compared to insulin glargine (41%) (p<0.05). Insulin degludec required a lower daily insulin dose (18.6±4.8 vs. 25.7±5.4 units, p=0.002) and had fewer hypoglycaemic episodes (12 vs. 40, p<0.05). Weight gain was lower in the insulin degludec group (0.85±0.4 kg vs. 1.65±0.5 kg, p=0.082), and quality of life scores improved significantly (p<0.05).
Conclusion: Insulin degludec demonstrated superior glycaemic target achievement, lower insulin requirements, and a significantly reduced risk of hypoglycemia compared to insulin glargine. These findings suggest insulin degludec as a favourable option for optimizing diabetes management in uncontrolled T2DM patients.
29. Normogram of RI and PI of Ductus Venosus between 11 – 14 Weeks of Gestation in North Indian Population: A Cross Sectional Study
Sachin S.K., Salma S.K., Avani A.K., Vibhor V.D., Aastha A.A., Aniket A.C., Abhishek A.S., Shaista S.E.
Abstract
Background: The DV plays a crucial role in maintaining optimal oxygenation and nutrient delivery during early fetal development. Doppler ultrasound studies have demonstrated that the velocity and volume of blood flow through the DV change with gestational age. During the course of pregnancy, the DV undergoes significant structural changes. Our study aims to establish normogram of RI and PI of ductus venosus between 11–14 weeks of gestation in North Indian population.
Methods: A cross sectional study of 210 antenatal women using observation cross sectional study was carried out at Era’s Lucknow medical college and hospital, Lucknow. RI and PI of ductus venosus was obtained in pregnant females of gestation age 11 – 14 weeks having singleton pregnancy and no structural abnormalities on ultrasound examination.
Results: Mean DV PI values for 11-12, 12-13- and 13–14-week gestational ages were found to be 0.946±0.132, 0.946±0.112 and 0.951±0.117 respectively. Statistically, there was no significant difference among different gestational ages for DV PI values. Mean DV RI values for 11-12, 12-13 and 13-14 week gestational ages were found to be 0.717±0.100, 0.717±0.094 and 0.717±0.094 respectively. Statistically, there was no significant difference among different gestational ages for DV RI values.
Conclusion: Normative range for DV PI or RI for 11 to 14 weeks gestational age can be used effectively with single representation for the entire span of this gestational age. Non-dependency of DV PI and RI on age, anthropometry and gravida status was reflective of its universal applicability for different ages, anthropometric and gravida strata.
30. Measurement of Peak Expiratory Flow Rate Values in School Going Children between 6-12 Yrs in an Urban Area of Bihar
Nand Kishor Singh, Mohammed Shamim, Bir Prakash Jaiswal, Akhilesh Kumar
Abstract
Background: The term “asthma” originates from Greek, describing breathlessness. Bronchial asthma has been since time immemorial and is defined as paroxysmal dyspnoea with intervals of healthy breathing. In India, asthma prevalence ranges from 2-17%. It’s a leading chronic respiratory illness in childhood, escalating globally due to pollution and industrialization. Diagnosis relies on methods like FEV1 and peak expiratory flow. Early detection is crucial to prevent complications. Peak expiratory flow rate (PEFR) is a vital diagnostic tool, especially in children, reflecting airway obstruction severity and treatment response.
Aim: (1) To study the peak expiratory flow rate in healthy school going children between 6-12 years.
(2) To study the correlation between PEFR and age, sex, weight, height and maximum chest circumference and to construct a Nomogram.
Materials and Methods: This cross sectional study was done on 350 subjects between 6 to 12 years of age who attended a school in urban area of Patna over a period of six months from October 2023 to March 2024. All patients who fulfilled the inclusion criteria were examined and their weight, height, chest circumference and PEFR were measured. For the determination of PEFR we used Mini Wright Peak Flow Meter.
Results: A total of 350 patients were included in the study of which 175 (50%) were males and 175 were females. Prediction equations were derived for PEFR with height in boys and girls. Normograms were plotted based on the observed values of PEFR in the study population.
Conclusion: Significant correlations were found between PEFR and biological variables like age, sex, weight, height and maximum chest circumference. Maximum positive correlation was seen for height, followed by age, weight and the least positive correlation was found for maximum chest circumference.
31. A Retrospective Analysis of Epidemiology and Pattern of Mandibular Fractures in Eastern Part of Uttar Pradesh, India
U. Vignesh, V.E. Shanthosh Kanna, Reading Well Kharmawlong
Abstract
Aim: The Incidence and pattern of mandibular fractures may vary according to the geographical area, religion, and socioeconomic status. The aim of this cross-sectional retrospective study is to evaluate the cause, risk factors, characteristics and clinical epidemiology of mandibular fractures in eastern part of Uttar Pradesh.
Materials and methods: The data collected included age, gender, mode of injury, mandible fracture location and associated fracture and treatment. In this study, various statistical techniques were employed to analyse the distribution and characteristics of cases across multiple variables. Descriptive statistics were utilized to summarize demographic data and percentages and proportions were calculated to provide a clear understanding of the relative prevalence of each category.
Results: Total 181 mandibular fractures were found in 132 patients. Majority of participants were male and belonged to the 20–30 years age group, comprising 54 individuals (40.9%). most common mode of injury was road traffic accidents (RTA) involving drivers, accounting for 47.7% cases with 68.3 % not wearing helmet and 31.7% wearing open face helmet. Parasymphysis fractures were the most prevalent, accounting for 37.6% of cases. This was followed by condyle fractures with 17.7% cases, angle fractures of 16.0% cases, and symphysis fractures of 15.5% cases. Less frequent were body fractures at 8.8%, ramus fractures 2.2%, and both coronoid and dento-alveolar fractures, each occurring 1.1% cases respectively.
Conclusion: The study provides important epidemiological data to formulate better future plans for preventing and treating mandibular injuries. The major populations at risk are young men and those driving two-wheelers with an open faced helmet or without one. Prevention is the key to reducing the incidence of maxillofacial fractures and it involves multiple strategies. This include the consistent use of protective gears like helmets and mouthguards, adherence to traffic rules, workplace and sports safety protocols.
32. Impact of Lifestyle and Diet on Obstructive Sleep Apnea Prevalence
Shreya Kantilal Koradia, Jayan Dineshbhai Dhoriyani, Jay Arvindbhai Bhoraniya, Panara Praful Bhagwanjibhai
Abstract
Introduction: Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repeated airway obstruction during sleep, leading to fragmented sleep and increased cardiometabolic risks. This study examines the association of lifestyle, dietary habits, and metabolic factors with OSA prevalence in a tertiary care center in Western Gujarat.
Materials and Methods: A cross-sectional study was conducted on 50 adult participants, assessing OSA risk using the Modified Berlin Questionnaire. Demographic data, anthropometric measurements, comorbid conditions, dietary patterns, and lifestyle habits were analyzed. Polysomnography and metabolic markers were evaluated in high-risk individuals.
Results: Among the 50 participants, 64% were classified as high risk for OSA, with a significant association observed with obesity (100%), hypertension (100%), dyslipidemia (66%), and abnormal 2D echocardiography findings (91%) (p < 0.05). High-risk individuals had a mean age of 60.81 years, with significantly higher BMI (36.18±2.99), neck circumference (43.94±6.01 cm), and waist-hip ratio (1.41±0.31) compared to lower-risk groups. Stored food consumption (87.5%) was significantly associated with higher OSA risk, while processed food intake showed a trend toward increased risk but was not statistically significant. Frequent fried food consumption (>2 times/week) was linked to increased OSA prevalence, while meal frequency, meal timing, and dinner-to-sleep intervals showed no direct correlation. Smoking and alcohol intake did not exhibit significant associations with OSA risk, though moderate-risk individuals reported higher addiction rates. Additionally, Grade 1 fatty liver (75.8%) and elevated triglyceride levels (159.56±26.84 mg/dL) were significantly prevalent among high-risk OSA participants.
Conclusion: OSA risk is significantly influenced by obesity, metabolic disorders, and dietary habits, emphasizing the need for early screening and lifestyle modifications to reduce associated health risks.
33. A Study of Acute Intestinal Obstruction in Adults
Keeni Dilip Reddy, Rathod Kapil
Abstract
Acute intestinal obstruction is one of common abdominal emergency and is associated with significant morbidity and mortality especially if it progresses to bowel ischemia. The diagnosis and management of the patient with intestinal obstruction is one of the more challenging emergencies that a general surgeon can come across. The study was conducted in the department of general surgery with symptoms and signs of acute intestinal obstruction admitted in the surgical ward. Fifty cases of intestinal obstruction have been studied. Patients belonged to above 20 age groups are included in present study. Our study shows causes of intestinal obstruction, Post operative Adhesions 36%, Obstructed Hernia 12%, Peritonitis 16%, Kochs Abdomen 12%, Volvulus 08%, Intussception 04%, Stricture 04%. In our study Out of 18 Post operative Adhesions 14 cases managed by Conservative methods, 4 by surgery. 4 cases of volvulus by surgery. 06 cases of Obstructed Hernia by surgery. 4 malignancy cases by surgery. Out of 8 Peritonitis cases 1 case by surgery and 7 by Conservative methods. Acute intestinal obstruction remains an important surgical emergency in the surgical field. Success in the treatment of acute intestinal obstruction depends largely upon its early diagnosis, skilful management and treating the pathological effects of the obstruction just as much as the cause itself.
34. Prospective study of Mass in Right iliac fossa
Emampuram Pandurangam Goud, Jadi Suresh
Abstract
Right iliac fossa mass is one of the most common clinical scenarios a surgeon encounters during their surgical practice. It poses a critical diagnostic dilemma for surgeons and requires considerable diagnostic skills. The mass arises from different anatomical structures with varied aetiologies that require a high clinical suspicion in its management. The reason being that the mass may range from being benign to most aggressively malignant lesion which encompasses various specialities of surgery like genitourinary, vascular, gynaecological and colorectal surgery. A total of 50 cases with mass in the right iliac fossa (RIF) were included in this observational study. Most common causes of mass in RIF were Appendicular mass (40%), Appendicular Abscess (18%), Ileocecal Tuberculosis (18%). Most common presenting symptoms were Pain (100%), fever (54%), Vomiting (48%). RIF mass is a challenging clinical scenario for the surgeons. Keeping in mind the various differential diagnosis with good clinical acumen supported by appropriate investigations, patients with RIF mass can be managed appropriately either by conservative or surgical management.
35. A Randomized Controlled Trial Comparing the Effects of Midazolam Versus Dexmedetomidine As Adjuvants in Adductor Canal Block
Suresh Kumar V., Bhukya Jodha Pallavi, Nalla Sahasa, Chakinala Shiva Kumar
Abstract
Background: Adductor canal block (ACB) is commonly used for postoperative analgesia in lower limb surgeries. Adjuvants such as midazolam and dexmedetomidine are added to local anesthetics to prolong analgesia and improve block characteristics.
Aim and Objectives: This study compares the efficacy and safety of midazolam versus dexmedetomidine as adjuvants in ACB.
Materials and Methods: A randomized controlled trial was conducted on 100 patients undergoing lower limb surgery under spinal anesthesia. Patients were randomly allocated into two groups: Group M (n=50) received midazolam as an adjuvant to local anesthetic, and Group D (n=50) received dexmedetomidine. The primary outcomes were the duration of sensory and motor block, time to first analgesic request, and total analgesic consumption in 24 hours. Secondary outcomes included hemodynamic parameters and adverse events.
Results: The sensory block duration was significantly longer in Group D (9.01±2.64 hours) compared to Group M (6.31±2.34 hours) (p<0.001). The motor block duration was also prolonged in Group D (7.05±1.14 hours) versus Group M (4.47±1.62 hours) (p<0.001). Group D had a delayed time to first analgesic request (10.47±2.24 hours vs. 7.13±2.36 hours; p<0.001) and reduced total analgesic consumption (61.45±7.26 mg vs. 90.32±8.61 mg; p<0.001). However, Group D experienced more bradycardia, hypotension, and sedation.
Conclusion: Dexmedetomidine as an adjuvant in ACB provides prolonged sensory and motor block, superior analgesia, and reduced analgesic consumption compared to midazolam but is associated with higher hemodynamic alterations. Careful monitoring is recommended when using dexmedetomidine in regional anesthesia.
36. Comparison of the Duration of Analgesia between Ropivacaine and Bupivacaine in Supraclavicular Brachial Plexus Block
Nalla Sahasa, Chakinala Shiva Kumar, Suresh Kumar V., Bhukya Jodha Pallavi
Abstract
Background: Supraclavicular brachial plexus block is widely used for upper limb surgeries, providing effective anesthesia and postoperative analgesia. This study aimed to compare the duration of analgesia between Ropivacaine and Bupivacaine in supraclavicular brachial plexus block.
Methods: A randomized, controlled study was conducted on patients undergoing upper limb surgeries under supraclavicular brachial plexus block. Patients were divided into two groups: one receiving 0.5% Ropivacaine and the other 0.5% Bupivacaine. The primary outcome was the duration of analgesia, and secondary outcomes included sensory and motor block durations, hemodynamic stability, and total analgesic consumption. Data were analyzed using appropriate statistical tests.
Results: The duration of analgesia was slightly prolonged in the Bupivacaine group (9.34±1.65 min) compared to the Ropivacaine group (8.97±1.80 min), though the difference was not statistically significant (p=0.236). Sensory and motor block durations were also comparable between the two groups (p>0.05). Hemodynamic parameters remained stable throughout the study, with minor fluctuations observed in both groups. The total analgesic consumption did not differ significantly between groups.
Conclusion: Both Ropivacaine and Bupivacaine provided effective analgesia for supraclavicular brachial plexus block, with no significant difference in duration of analgesia. Ropivacaine demonstrated better hemodynamic stability, suggesting its potential as a safer alternative. Further large-scale studies are warranted to confirm these findings.
37. Patient Satisfaction and Postoperative Analgesia in Nerve Blocks with and without Adjuvant Fentanyl
Chakinala Shiva Kumar, Suresh Kumar V., Bhukya Jodha Pallavi, Nalla Sahasa
Abstract
Background: Effective postoperative pain management is crucial for patient satisfaction and recovery.
Aim and Objectives: This study evaluates the impact of adjuvant fentanyl on postoperative analgesia and patient satisfaction in nerve blocks.
Materials and Methods: A comparative study was conducted on 120 patients undergoing surgery under nerve block anesthesia. Patients were divided into two groups: Group A (n=60) received a nerve block without fentanyl, while Group B (n=60) received a nerve block with fentanyl as an adjuvant. The duration of postoperative analgesia, total analgesic consumption, pain scores, patient satisfaction, and adverse events were assessed.
Results: The mean duration of postoperative analgesia was significantly longer in Group B (8.85 ± 1.63 hours) than in Group A (6.11 ± 1.14 hours) (p<0.001). Total analgesic consumption was lower in Group B (98.97 ± 25.27 mg) compared to Group A (149.44 ± 30.0 mg) (p<0.001). VAS scores were comparable at different time intervals; however, patient satisfaction was significantly higher in Group B (p=0.049). Adverse events, including nausea, pruritus, and respiratory depression, were slightly more frequent in Group B but were clinically manageable.
Conclusion: The addition of fentanyl to nerve blocks significantly prolongs analgesia duration, reduces analgesic consumption, and enhances patient satisfaction. While adverse events were slightly more common, they did not outweigh the benefits. These findings support the use of fentanyl as an adjuvant in regional anesthesia for improved postoperative pain management and patient comfort.
38. Comparative Study of Ultrasound-Guided Adductor Canal Block Versus Femoral Nerve Block for Postoperative Analgesia in Total Knee Arthroplasty
Bhukya Jodha Pallavi, Nalla Sahasa, Chakinala Shiva Kumar, Suresh Kumar V.
Abstract
Background: Effective postoperative analgesia is essential for early rehabilitation following total knee arthroplasty (TKA). This study compares the efficacy of ultrasound-guided adductor canal block (ACB) and femoral nerve block (FNB) in postoperative pain management.
Methods: A randomized comparative study was conducted on patients undergoing TKA, divided into ACB and FNB groups. Pain scores were assessed using the Visual Analog Scale (VAS) at multiple time points postoperatively. Total opioid consumption, time to ambulation, quadriceps strength, and patient satisfaction were also evaluated.
Results: Both techniques provided effective analgesia, but ACB demonstrated superior outcomes in key parameters. The ACB group had significantly lower VAS scores at 12 hours (p = 0.027) and reduced opioid consumption (p = 0.041) compared to the FNB group. ACB also facilitated earlier ambulation (p = 0.008) without significant compromise in quadriceps strength (p = 0.253). Additionally, patient satisfaction scores were significantly higher in the ACB group (p = 0.031).
Conclusion: ACB is an effective alternative to FNB for postoperative analgesia in TKA, offering better pain control, lower opioid requirements, earlier mobilization, and improved patient satisfaction without impairing quadriceps strength. These findings support ACB as a preferred analgesic technique for enhanced recovery following TKA.
39. Neonatal Small Bowel Obstruction: Etiology, Clinical Presentation, and Diagnostic Evaluation in a Tertiary Care Centre: A Prospective Study
Ade Gangadhar, Gudelli Prashanth Reddy, Gurram Bharadwaj Naidu
Abstract
Background: Neonatal small bowel obstruction (SBO) is a critical surgical emergency requiring timely diagnosis and intervention to prevent morbidity and mortality. This study aimed to evaluate the etiology, clinical presentation, and diagnostic approaches for neonatal SBO in a tertiary care centre.
Methods: A prospective study was conducted in a neonatal surgical unit, enrolling neonates presenting with features of SBO such as bilious vomiting, abdominal distension, and failure to pass meconium. Clinical examination, laboratory investigations, and imaging modalities, including abdominal radiographs, ultrasonography, and contrast studies, were utilized for diagnosis. Surgical findings and histopathological reports were documented.
Results: Among 290 neonates, Intestinal atresias accounted for 152 (52.41%) of the 290 neonates, making it the most common cause of SBO. With 48 cases (16.55%), malrotation was the second most common cause. 144 cases (49.66%) had a combination of vomiting and abdominal distension, which was the most frequent symptom. Abdominal x-ray suggested the most common finding was the multiple bubble sign, seen in 113 neonates (38.97%), indicative of distal small bowel obstruction.
Conclusion: Congenital intestinal atresia and malrotation are the leading causes of neonatal SBO. Imaging plays a crucial role in preoperative diagnosis, enabling timely surgical management. Early recognition and comprehensive evaluation in a tertiary care setting improve outcomes.
40. A Retrospective Study of Fatal Head Injuries in Road Traffic Accidents at a Tertiary Care Centre
Krishna Bahadur Gurung, Priyal Jain, Saagar Singh
Abstract
Background: Road traffic accidents (RTAs) are a major global public health issue, with head injuries being the leading cause of death. Despite the protective role of the skull, high-impact trauma in RTAs often results in severe or fatal traumatic brain injuries (TBIs). This study aims to analyse the patterns of fatal head injuries sustained in RTAs at a tertiary care center, providing insights into their severity, distribution, and associated risk factors.
Methods: This retrospective, cross-sectional study examined 100 cases of fatal head injuries due to RTAs between June 2024 and September 2024 at the Department of Forensic Medicine and Toxicology, Ratlam. Data were obtained from autopsy reports and investigating authorities, analysing demographic distribution, injury patterns, and contributing factors using Microsoft Excel.
Results: Males accounted for 87% of cases, with the highest fatalities in the 21–30 age group (36%). Most accidents occurred between 6 PM and 12 AM (38%). The majority of skull fractures involved both the cranial vault and base (63%). Subdural and subarachnoid hemorrhages were the most frequent intracranial hemorrhages (78.57%). Two-wheeler accidents were the most common (71%), with low helmet usage (2.81%).
Conclusion: The findings underscore the urgent need for improved road safety regulations, stricter helmet enforcement, and enhanced emergency trauma care to reduce the incidence and severity of fatal head injuries in RTAs.
41. A Comparison of Bispectral Index Values Produced By Isoflurane and Halothane at Equal End-Tidal Minimum Alveolar Concentration
Lokesh Kumar Meena, Hemant Yadav, Deepak Kumar Meena
Abstract
Background: The Bispectral Index (BIS) is a valuable tool for monitoring the depth of anesthesia. Isoflurane and halothane are inhalational agents with distinct pharmacological profiles. This study compares BIS values produced by isoflurane and halothane at equal end-tidal minimum alveolar concentrations (MAC) to enhance anesthetic management during surgery.
Methods: In a double-blinded, randomized comparative study, 50 patients were divided into two groups: Group I (isoflurane) and Group H (halothane), each with 25 patients. BIS and hemodynamic parameters were recorded at end-tidal MAC values of 0.5, 1.0, and 1.5 after stabilization periods of 10 minutes at each concentration.
Results: BIS values decreased with increasing MAC in both groups. At equivalent MAC levels, isoflurane produced significantly lower BIS values than halothane (p < 0.05). Hemodynamic parameters remained stable and comparable between groups. Recovery times were slightly shorter in the isoflurane group, but differences were not statistically significant.
Conclusion: Isoflurane results in lower BIS values compared to halothane at equal MAC concentrations, indicating a deeper hypnotic effect. BIS monitoring should be interpreted cautiously, considering the specific anesthetic agent used.
42. Retrospective Analysis of the Outcomes of Total Hip Arthroplasty (THA) vs. Hemiarthroplasty for Hip Fracture
Ankit Prakash, Ajinkya Gautam, Prashant, Mahesh Prasad
Abstract
Background: Hip fractures are a significant cause of morbidity and disability among older adults, often requiring surgical intervention. THA and Hemiarthroplasty are the two primary surgical options, each with distinct advantages and limitations. This study retrospectively analyses and compares the outcomes of THA and Hemiarthroplasty in hip fracture patients to determine the most effective approach based on functional recovery, complications, and overall patient outcomes.
Methods: A retrospective observational study was conducted at PMCH from March 2023 to September 2024, including 50 patients who underwent either THA or Hemiarthroplasty. Patients were selected based on inclusion and exclusion criteria, with data collected from medical records, radiographic findings, and post-operative assessments. Outcome measures included functional recovery (Harris Hip Score, mobility status), postoperative complications (dislocation, infection, mortality), length of hospital stay, reoperation rates, pain levels, and patient satisfaction. Statistical analysis was performed to compare the results between the two groups.
Results: THA demonstrated superior functional recovery, with significantly higher Harris Hip Scores and better mobility at six months. However, it was associated with a higher risk of dislocation and longer hospital stay compared to Hemiarthroplasty. Patients who underwent Hemiarthroplasty had a lower incidence of dislocation but experienced higher residual pain and an increased need for revision surgery due to acetabular cartilage wear. Mortality rates were similar in both groups, indicating that preoperative health status played a crucial role in survival outcomes.
Conclusion: THA provides better functional outcomes and lower long-term pain, making it the preferred choice for younger, active patients. Conversely, Hemiarthroplasty remains suitable for older, frail patients with limited mobility due to its lower surgical complexity and reduced risk of dislocation. A patient-centered approach is essential in surgical decision-making to optimize clinical outcomes.
43. Evaluation of the Effectiveness of Different Types of Fixation for Distal Femur Fractures
Ankit Prakash, Ajinkya Gautam, Prashant, Mahesh Prasad
Abstract
Background: Due to their intricacy, distal femur fractures are difficult to treat. Surgery is typically needed to improve mobility, joint stability, and limb alignment. External Fixators, Retrograde Intramedullary Nails (RIN), and Locking Compression Plates are employed according on the fracture, patient, and surgeon. Choosing the optimal fixing method requires more clinical and radiological investigation.
Objective: This study aims to compare the effectiveness of different fixation techniques for distal femur fractures in terms of functional recovery, radiological healing, complication rates, and rehabilitation outcomes.
Methods: A retrospective cohort study at Patna Medical College and Hospital (PMCH) from March 2023 to September 2024 included 50 surgically treated distal femur fracture patients. Participants had to be 18 years old and follow up for six months after surgery. Polytrauma, pathological fractures, and poor medical records were excluded. Demographics, fracture classification (AO/OTA), fixation method (LCP, RIN, External Fixator), functional outcomes (knee range of motion, pain score, weight-bearing status), and complications were collected and analysed. Statistical comparisons were made using t-tests and chi-square tests with a significance level of p<0.05.
Results: Among 50 patients with distal femur fractures, LCP fixation showed superior outcomes, with a mean knee ROM of 110° ± 15 (p=0.012) and lower pain scores (VAS: 2.5 ± 1.2, p=0.021). Full weight-bearing was achieved faster in LCP (80%) than RIN (65%) and External Fixators (40%) (p=0.018). LCP had the shortest healing time (14.2 ± 3.1 weeks, p=0.026), lower complications, and shorter hospital stay (7.5 ± 1.8 days, p=0.029). These findings indicate LCP as the most effective fixation method, promoting faster recovery and better functional outcomes.
Conclusion: The study suggests LCP is the best distal femur fracture repair method due to its lower complications and faster recovery. RIN can still treat non-articular fractures, although external fixation should only be utilized in extreme cases for temporary stabilisation or soft tissue damage. These findings require more prospective trials to establish that customized treatment selection improves patient outcomes.
44. Study of Spectrum and Clinical Profile of Benign Breast Disease in the Rural Area: An Observational Study
Ritesh Ranjan, Tanisha Choudhary
Abstract
Background: Benign Breast Disease (BBD) such fibroadenomas, breast cysts, and fibrocystic changes cause most breast pathology. Up to 30% of women will get these diseases. Rural healthcare access, health literacy, and diagnostic resources might delay diagnosis and treatment, lowering quality of life.
Methods: An observational study was conducted at Safdarjung Hospital, affiliated with Vardhman Mahavir Medical College, in New Delhi from October 5, 2017, to October 4, 2020. In the sample were 75 women with noncancerous breast problems. Data collection covered demographics, clinical presentation, diagnosis, and treatment. All women with BBD were included, but those with malignancies or poor medical records were excluded. Data analysis used descriptive statistics to synthesise clinical findings and patient characteristics, and chi-square testing to uncover statistically significant relationships.
Results: Fibroadenomas led the study’s benign breast disorders with 40% frequency. The cases had 20% fibrocystic changes and 33.3% breast cysts. The majority of women experienced breast lumps (73.3%), discomfort (40%) and nipple discharge (6.7%). Mammography was used by 60% of patients, second to ultrasound (93.3%). Fibroadenomas were usually surgically removed, while cysts were drained or treated conservatively. The study found that mammography supplemented ultrasonography for initial evaluation and surveillance in elderly patients.
Conclusion: This study on Benign Breast Diseases in rural areas emphasises the importance of readily available diagnostic and treatment options. The results suggest rural communities should focus breast health education and awareness campaigns and improve healthcare systems to diagnose and treat breast cancer faster. These methods may improve benign breast disease outcomes and reduce anxiety. Future research should include a larger sample size and additional factors affecting benign breast disease appearance and therapy.
45. Serum Ferritin Level, A Prognostic and Diagnostic Marker in Dengue Virus Infected Paediatric Population
Dasgupta (Ghosh) Jayita, Konar Jayashree, Bandyopadhyay Pritha, Dasgupta Sambit, Bandyopadhyay Purbasha
Abstract
Objectives: To access variation in serum ferritin levels and correlational analysis of serum ferritin level and dengue NS1 antigen level in dengue virus infected paediatric population.
Materials and Methods: An institution based analytical case control study was conducted in the department of Biochemistry in collaboration with departments of Microbiology, Pathology and Paediatrics. Paediatric patients were divided in three groups, one with clinically diagnosed dengue fever, other with fever of other etiologies and another consisting of individuals without any fever taken as controls. As far as possible age and sex matched control subjects were recruited for the study. 20 patients with clinically diagnosed dengue fever were taken as a cohort, 20 patients with fever of other etiologies were taken as a separate cohort and 20 subjects as control.
Result: In our study we found a significant variation in serum ferritin level amongst the paediatric patients included in our study with the mean serum ferritin level in paediatric patients infected with dengue virus being 903.25 ng/ml and that in paediatric patients with fever of other etiologies being 458.35 ng/ml and the mean serum ferritin level in control group being 223.25 ng/ml.
Conclusion: There exists significant difference in serum ferritin level among dengue virus infected group and other febrile illnesses group with serum ferritin being significantly higher in the dengue virus infected group as compared to the fever of other etiologies group. Thus serum ferritin could serve an effective biomarker in diagnosis and monitoring prognosis of dengue fever in the paediatric age group.
46. A Study of Diagnostic Utility of CT Enterography in Small Bowel Diseases
Mushini Deepthi, Dondha Shravani, Gundeti Dweti
Abstract
Background: Diagnosing the diseases of the small intestine has been challenging because of its anatomical complexity limited accessibility and non-specific clinical presentation. CT enterography (CTE) is a non-invasive modality that is commonly used for the evaluation of small bowel diseases. This current study aimed to evaluate the diagnostic utility of CTE by analyzing its accuracy, sensitivity, and specificity in detecting various small bowel pathologies.
Methods: A prospective observational study was conducted among 25 cases aged 16 – 65 years, including 14 males and 11 females presenting with clinical suspicion of small bowel diseases based on clinical, laboratory, or other imaging investigations. They were subjected to CT enterography on a 128-slice CT scanner using iso-osmotic mannitol as neutral enteral contrast.
Results: Among 25 cases, the most common clinical diagnosis was small bowel obstruction (40%), followed by Crohn’s disease and tumors (16% each). CTE findings included bowel thickening (76%), lymphadenopathy (40%), and bowel dilation (32%). Adequate bowel distension was achieved in 76% of cases. CTE showed 95.24% sensitivity, 100% specificity, and 96% overall accuracy. However, it missed some cases, including Crohn’s disease and tuberculosis. Despite minor discrepancies, CTE proved to be a valuable diagnostic tool for small bowel pathologies, aiding in early detection and management.
Conclusion: CTE is a highly accurate and non-invasive diagnostic tool for small bowel diseases, particularly in identifying inflammatory and obstructive conditions. However, its limitations in detecting certain malignancies and differentiating overlapping pathologies highlight the need for other diagnostic methods such as histopathology.
47. Knowledge, Attitude and Practice Towards Needle Stick Injury Among Nursing Students in a Tertiary Care Teaching Hospital
Abhishek Pokkuluri, Butta Ramesh, Aswan Gaddala, Archana Carolin, Deshmukh Shreyas Satyendra, Diya S Bhandary, Devyani Krushna Kardile, Charishma D
Abstract
Background: Needlestick injuries, or NSIs, present a grave danger to healthcare workers (HCWs), constituting significant occupational hazards due to the potential transmission of various bloodborne diseases. Among the pathogens that can be transmitted through NSIs are hepatitis B and C viruses, as well as the human immunodeficiency virus (HIV/AIDS), posing a serious threat to the health of healthcare workers.
Aim: To assess the knowledge, attitude and practice of nursing students towards needle stick injuries.
Materials& Methods: An institutional based cross-sectional study was conducted on 186 nursing students selected by simple random sampling. Initially, a pre-test was conducted .Then an intervention in form of lecture and simplified videos pertaining to the need of study was done following which post-test was conducted.
Results: On comparing the results of pre-test and post-test, the calculated mean post-test knowledge score of 17.35 was higher than calculated mean pre-test knowledge score of 15.20, which meant that the intervention of lecture and video-based teaching programme was effective and the result was statistically significant. Comparison of KAP score with pretest and post-test was found to be statistically significant (p<0.05). On comparison of socio demographic variables with post-test knowledge, there was no statistical significance.
Conclusions: The intervention proved successful in enhancing nursing students’ understanding and implementation of safety measures to prevent needlestick injuries.
48. A Comparision of Sedation Quality of Combination of Dexemedetomidine and Midazolam with Propofol and Fentanyl using Ramsay Sedation Score in Tympanoplasty under Monitered Anaesthesia Care
Kirti Ahirwal, R. P. Kaushal, Twinkle Kewalramani, Neelesh Nema
Abstract
Background: Several Middle Ear Surgeries can be done under either Local anaesthesia with sedation or General Anaesthesia. However, patients sometimes are unable to tolerate constant supine, frequent head and neck positionings, noise of suction, manipulation of instruments, pain of local anaesthetic drug infiltration etc. Monitored Anaesthesia care is a planned procedure for 10-30% of all surgeries. MAC typically involves administration of local anaesthesia in combination with IV sedatives, anxiolytic and/or analgesic drugs which is a common practice during Tympanoplasty.
Methodology: The present study was designed to compare α-2 agonist Dexmedetomidine and iv sedative midazolam with intravenous Propofol and Fentanyl using ramsay sedation score in tympanoplasty. 50 patients were registered in this study; patients were randomly allocated into 2 groups (group DM and group PF). Group DM received IV Midazolam 0.05mg/kg and Dexmedetomidine at a loading dose of 1mcg/kg over 10 minutes followed by continuous infusion 0.5 mcg/kg/hr till surgery was over. Other group PF received iv 1 mg/kg propofol and 1 mcg/kg fentanyl in titrated doses. Degree of sedation and pain intensity was assessed by using Ramsay Sedation Score (RSS). P-value was used for statistical analysis.
Results: Higher repeated doses of midazolam were required for group DM patients (6.25±4.574) as compared to Group DF participants injected with Fentanyl (6±8.289). Patient and surgeon satisfaction score was more satisfactory in Group PF (Propofol and Fentanyl) than Group DM( dexmedetomidine and midazolam). Post operative Visual Analogue Score (VAS) was higher in group DM (2.18±1.19) than group PF (0.593±0.2391). No post-operative complications were seen in both groups.
Conclusion: We found that propofol-Fentanyl is a better combination in Tympanoplasty surgeries under monitored anesthesia care. It not only improves the intra-operative analgesia but also gives better post-operative analgesia.
49. Delirium in Hospitalized Patients: A Cross-Sectional Study
Mrunmayee Pradhan, Mihir Ranjan Naik, Udit Kumar Panda
Abstract
Background: Delirium is a common and serious condition causing great impact on patients at the time of hospitalization, often more in Intensive Care Units. It is essential to understand the phenomenology and severity of delirium for patient outcomes.
Methods: This is a cross-sectional, hospital-based study conducted at SCB Medical College, Cuttack, on 50 patients aged between 16 to 60 years referred from the Central ICU and general inpatient units. The level of delirium was assessed using the Delirium Rating Scale Revised 98 (DRS-R98). Details were gathered through a semi-structured proforma and laboratory investigations that included analyses of liver and renal function tests, complete blood counts, serum electrolytes, and CT imaging.
Results: The total number of patients who fulfilled the DSM-5 criteria for delirium was 54, and 92% presented acutely. Hyperactive delirium presented in 68%, and among the biochemical abnormalities, deranged liver and renal functions were found in 34%. A high mean DRS-R98 score revealed severity of delirium to be more pronounced among ICU patients. Cognition impairment correlated positively with delirium severity.
Conclusion: High prevalence and severity of delirium in hospitalized patients, particularly in the ICU. There is a clear association between delirium and cognitive impairment, with the underlying cause being medical diseases, thereby establishing that early detection with targeted interventions is warranted. Managed care of patients should be anchored around delirium management protocols to improve outcomes.
50. Prevalence of RTIs/STIs and Treatment Seeking Behaviour among the Reproductive Age Group, Married Women in RHTC and UHTC Areas of Jhalawar Medical College (Raj.)
Vandana Meena, Reshma Reja, Mohammed Shadab Gouri, Pankaj Gupta
Abstract
Background: Although RTI/STI affect both women and men but women are more susceptible to infection and are less likely to seek treatment than men. It is the second cause of healthy life lost among women of reproductive age after maternal morbidity and mortality in developing countries.
Objectives: To find and compare the prevalence of RTI/STI and its association with sociodemographic variable and to identify the treatment seeking behaviour of reproductive age group married women in Rural and Urban Slum areas.
Methodology: A community based Cross-sectional study was done in rural area of RHTC and urban slum area of UHTC under Department of Community Medicine, Jhalawar Medical College, and Rajasthan. Multistage Stratified Random Sampling technique was used. Total 750 subjects were selected, 375 from rural area and 375 from urban slum area.
Results: Out of 750 participants maximum were belonging to 25-34 year age group. Point-prevalence of RTI/STI in Urban slum area (22.4%) was more than rural area (17.9%). Per vaginal discharge was the most common symptom in women of both Rural (92.2%) and Urban slum area (90.0%). 70% of the study participant sought treatment out of which 96% were compliant. Majority of women took treatment at government hospital (62%).
Conclusion: Prevalence of RTI/STI in this study was found less but and treatment seeking behaviour was good but it was not as per NACO guideline of syndromic management.
51. A Prospective Study on Thrombocytopenia in Sepsis and Its Correlation with Clinical Outcomes and Mortality
Shitalben Patel, Kapil Bavarva, Milan Mori, Nidhi Saradva
Abstract
Introduction: Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection, leading to organ dysfunction and high mortality. Thrombocytopenia, a common hematological abnormality in sepsis, is associated with increased ICU stay, bleeding risk, and poor clinical outcomes.
Materials and Methods: This prospective observational study was conducted at a tertiary care hospital over 12 months, including adult ICU patients diagnosed with sepsis, severe sepsis, or septic shock. Patients with pre-existing platelet disorders, chronic liver disease, recent chemotherapy, or antiplatelet therapy were excluded. Clinical and laboratory data, including platelet counts, coagulation profile, inflammatory markers, and sepsis severity scores (SOFA, APACHE II), were analyzed. Primary outcomes included 28-day mortality, while secondary outcomes assessed ICU stay duration, major bleeding events, and transfusion needs.
Results: Out of 115 ICU patients with severe sepsis or septic shock, 80 met the inclusion criteria, with 60% male and a mean age of 71.5 years. Septic shock was present in 90% of cases, and pneumonia (40%) was the most common infection source. Thrombocytopenia developed in 38 patients (47.5%), with 52.6% present at admission and 47.4% occurring during hospitalization. Thrombocytopenic patients had higher APACHE III scores (p=0.002), increased ICU stay (p=0.002), and higher rates of acute kidney injury (p=0.03). Severe thrombocytopenia was seen in 21%, and major bleeding was significantly more frequent (p=0.02). Patients with thrombocytopenia required more PRBC transfusions (p=0.04) and platelet transfusions (p<0.0001). Lactate levels (p=0.01) and prolonged vasopressor duration (p=0.03) were independent predictors of thrombocytopenia. 28-day mortality was higher in thrombocytopenic patients (36.8% vs. 23.8%), though not statistically significant (p=0.14).
Conclusion: Thrombocytopenia in sepsis is associated with increased ICU stay, organ dysfunction, and a higher need for transfusions. Early identification and monitoring of platelet trends can aid in risk stratification and improve patient management.
52. To Study the Effects of Intravenous Tramadol and Intravenous Dexmedetomidine in Patient Undergoing Laproscopic Cholecystectomy in Prevention of Postanaesthesia Shivering
Hiral Khunti, Birju Chavada, Jitensinh Vadher, Meetkumar Rajendrabhai Kachhia
Abstract
Introduction: Post-anesthesia shivering is a common yet significant concern in laparoscopic cholecystectomy, leading to discomfort and increased oxygen consumption. Tramadol, an opioid analgesic, and Dexmedetomidine, and α2-adrenergic agonist, are both used to prevent shivering through different mechanisms. This study compares their efficacy in reducing post-anesthesia shivering, focusing on onset, severity, and associated complications to determine the more effective agent for perioperative management.
Materials and Methods: This randomized, prospective study included ASA I–II patients undergoing laparoscopic cholecystectomy under general anesthesia. Patients were assigned to receive either intravenous Tramadol (1 mg/kg) or Dexmedetomidine (0.5 µg/kg) before extubation. Shivering incidence and severity were assessed at 1 and 2 hours postoperatively, along with hemodynamic parameters and adverse effects over 24 hours. Statistical analysis was performed using SPSS version 23, with a p-value of <0.05 considered significant.
Results: Both Dexmedetomidine and Tramadol groups had comparable baseline characteristics, including age, sex distribution, ASA grade, and surgical duration (p > 0.05). However, the incidence of shivering was significantly higher in the Tramadol group (26 out of 33) compared to the Dexmedetomidine group (7 out of 33) (p < 0.001). While Tramadol led to earlier shivering cessation, recurrence was significantly lower in the Dexmedetomidine group, indicating better long-term control. Hemodynamic parameters such as SBP, DBP, pulse rate, SPO₂, and temperature remained stable across both groups, with no significant differences (p > 0.05), except for a slightly higher SBP after extubation in the Tramadol group (p = 0.029). Notably, nausea was significantly more frequent in the Tramadol group (14 out of 20 cases) compared to Dexmedetomidine (6 out of 20) (p = 0.039), highlighting Dexmedetomidine’s better tolerability.
Conclusion: Dexmedetomidine was more effective than Tramadol in preventing post-anesthesia shivering, with lower incidence, longer duration of action, and fewer complications. Both drugs maintained stable hemodynamics, but Tramadol had a higher incidence of nausea.
53. Prevalence of Helicobacter Pylori Infection among Symptomatic Upper Gastrointestinal Diseases Including Cholelithiasis, in Southern Odisha – A Prospective Study
Inuganti Gopal, Biswa Ranjan Nayak, Sumita Tripathy, Debabrata Patra
Abstract
Background: Helicobacter pylori (
H. pylori) is a globally prevalent Gram-negative, spiral-shaped bacterium known to colonize the human gastric mucosa. Its role in various gastrointestinal diseases, including gastritis, peptic ulcer disease (PUD), gastric carcinoma, and, to a lesser extent, cholelithiasis, has been extensively studied. The prevalence of
H. pylori infection varies geographically, influenced by socioeconomic status, hygiene, sanitation, and dietary factors. Southern Odisha over the years witnessed major changes in its food habits, migration and Environment and the majority of the Population are below the poverty line and most of the people are migrant laborers. Incidence of gastrointestinal diseases including Gastritis, PUD, Cholelithiasis and Gastric Carcinoma are on a rise. This study aims to investigate the prevalence and association of
H. pylori with gastritis, peptic ulcer disease, cholelithiasis and carcinoma stomach, using rapid urease test (RUT) and histopathology as diagnostic modalities. This study analyzes the prevalence of
H. pylori in Southern Odisha, incorporating age, sex, food habits, and socioeconomic status to better understand the disease burden and risk factors.
Methods: A prospective case control study was conducted on 325 patients in the Post Graduate Department of General Surgery, MKCG Medical College, Berhampur, Odisha presenting with dyspeptic symptoms undergoing upper gastrointestinal endoscopy and Cholecystectomy. 100 normal asymptomatic individuals were taken as control group. Biopsy specimens were obtained for RUT and histopathological examination. Patients were categorized into four groups based on diagnosis: gastritis (n=120), peptic ulcer disease (n=80), carcinoma stomach (n=55), and cholelithiasis (n=70). Data regarding demographic factors, socioeconomic status, and rural-urban distribution were collected and analyzed. Statistical analyses included prevalence estimation, chi-square tests for categorical variables, odds ratio calculations, and logistic regression modeling to assess the association between
H. pylori and the studied gastrointestinal diseases.
Results: The overall prevalence of
H. pylori in symptomatic upper gastrointestinal diseases was 64.92%, and that of control group was 30%. The highest prevalence of
H. pylori was observed in peptic ulcer disease (75%), followed by carcinoma stomach (72.7%) and gastritis (65%). Cholelithiasis had a prevalence of
H. pylori (47.14%). Age distribution analysis revealed that infection was most prevalent in the 51-60 years age group, with a male predominance (60% male vs. 40% female). Rural populations exhibited a higher prevalence (58.5%) compared to urban populations (41.5%). Socioeconomic analysis demonstrated a significant correlation, with higher prevalence observed in low (43.1%) and middle (36.9%) socioeconomic groups compared to high socioeconomic status (20.0%). Histopathological examination confirmed
H. pylori in Peptic Ulcer (OR = 7.00, p < 0.0001) has the strongest association with
H. pylori. Carcinoma Stomach (OR = 6.22, p < 0.0001) also shows a strong association. Gastritis (OR = 4.33, p < 0.0001) is significantly associated. Cholelithiasis (OR = 2.08, p = 0.025) is significant, suggesting
H. pylori may be a risk factor.
Conclusion: Among 325 patients, 211 (64.92%) were
H. pylori positive, detected through RUT and histopathology. The highest prevalence of
H. pylori was observed in peptic ulcer diseases as 75% then in carcinoma stomach 72%,
H. pylori was found in 33 cases of cholelithiasis, shows an association which is statistically significant. In 40 biopsy-proven gastric carcinoma cases,
H. pylori was present in a significant proportion, reinforcing its role in gastric malignancy.
54. Accuracy of Fine Needle Aspiration Cytology versus core needle biopsy for Diagnosis of Breast Lesions
Juhi Chauhan, Yachna Setu, Mayank Anand, Amir Faiz
Abstract
Background and Objective: Fine needle aspiration cytology and core needle biopsy are reliable procedures for breast cancer detection. Core needle biopsy is an established alternative to surgical biopsy for diagnosis and prognostication.The objective of the study was to compare between Fine Needle Aspiration Cytology (FNAC) and Core Needle Biopsy (CNB) in the diagnosis of breast lesions.
Materials and Methods: A prospective study was done on 50 cases at Department of Pathology; KVG Medical College and Hospital. Sullia, DK. Patients undergoing all three procedures (Fine Needle Aspiration Cytology, Core Needle Biopsy and subsequent excision surgeries were selected. May Grunwald Giemsa (MGG) and Papaniculou (PAP) staining were performed on cytology smears. Haematoxylin and Eosin (H&E) staining was done on both the CNB and tissue specimens obtained from subsequent excision surgeries to see the histological features.
Result: The majority of the patients in the study were in the age group of 31-50 years. In our study, FNAC showed a sensitivity, specificity, PPV, NPV of 87%, 92.59%,90.94%,89.28%.CNB had a sensitivity, specificity, PPV, NPV 95.65%,96.22%,95.68% and 96.30%. It was also observed that the combination of both FNAC and CNB results have more improved sensitivity (98.55%) and specificity (99.99%) for diagnosis of breast lesions.
Conclusion: The diagnostic accuracy of the combined assessment of FNAC and CNB against final histopathologic diagnosis for breast lesions was better than that of FNAC or CNB alone. This finding shows that both the techniques complement each other. FNAC and CNB are used as the first- and second-line methods of pathological diagnosis respectively.
55. An Autopsy-Based Study of Head Injuries with a Focus on Intracranial Hemorrhage
Md. Mojahid Anwar
Abstract
Background: Worldwide, head injuries, particularly those that result in intracranial hemorrhages, are frequent causes of death and disease. This study aims to analyze the autopsy findings of individuals who succumbed to head injuries, with a focus on the nature and distribution of intracranial hemorrhages.
Methods: This retrospective cross-sectional study included one-year cases of head injuries that were autopsied at our institution. The presence, location, and type of intracranial hemorrhages were recorded. The relationship between the type of hemorrhage and demographic information like age and gender was looked at in the data. Results: Of the 100 autopsy cases reviewed, 65% showed the presence of intracranial hemorrhages. Subdural hematoma was the most common type of hemorrhage, followed by epidural hematoma. Intracerebral hemorrhage was also frequently observed, particularly in older patients. Statistical analysis revealed a significant correlation between the severity of hemorrhages and the age of the patient.
Conclusion: Intracranial hemorrhages are a major cause of death in patients with head injuries. The results show that early detection and treatment of these hemorrhages are crucial to lowering mortality rates. In these cases, the most common type of hemorrhage is still subdural hematomas.
56. An Unusual Cause of Acute Abdomen: Superior Mesenteric Artery Occlusion Leading to extensive Small Bowel Gangrene
Pritam Adak, Rahul Dasgupta, Arup Kumar Ghosh, Manojit Sarkar, Amit Ray
Abstract
Superior mesenteric artery (SMA) occlusion is a rare but life-threatening vascular emergency that can lead to ischemia and gangrene of the small intestine. Here, we report a unique case of an elderly male patient presenting with acute abdominal pain and shock, later diagnosed with SMA thrombosis resulting in extensive small bowel gangrene. This case emphasizes the importance of early recognition, prompt imaging, and urgent surgical intervention in SMA occlusion to prevent fatal outcomes.
57. A Study on the Pathological Variants of Sinonasal Masses in a Rural Tertiary Care Hospital in North Bengal
Monideepa Sarkar, Radheshyam Mahato, Soumendu Bhaumik, Saumik Das, Shuvam Gupta, SK Azaharuddin, Tuhin Sasmal
Abstract
Introduction: Sinonasal masses encompass a wide range of benign, malignant, and non-neoplastic conditions, presenting diagnostic and therapeutic challenges. Their prevalence, etiological factors, and management strategies vary significantly across different populations. This study investigates the clinicopathological patterns of sinonasal masses in a rural tertiary care setting in North Bengal.
Objectives: The study aimed to analyze the demographic characteristics, identify the pathological variants, and evaluate the clinical presentations and management strategies of sinonasal masses in a rural population.
Methodology: An observational study was conducted on 86 patients aged >5 years presenting with sinonasal masses at North Bengal Medical College over 16 months. Data were collected through clinical evaluation, imaging, and histopathological examination. Treatment approaches included surgical and conservative methods.
Results: The majority of patients (56.9%) were aged 31–60 years, with a male predominance (62.8%). Nasal polyps were the most common diagnoses (59.3%), followed by mucormycosis (9.3%) and other malignancies (11.6%). Benign lesions accounted for 88.4% of cases. Endoscopic sinus surgery was the most frequently employed management method (64%).
Conclusion: This study highlights the predominance of benign sinonasal masses, particularly nasal polyps, and underscores the importance of early diagnosis and minimally invasive surgical interventions. Future research should explore risk factors and long-term outcomes.
58. Correlation of Upper Gastrointestinal Bleeding with Thrombocytopenia in Liver Cirrhosis Patients
Mahesh Kumar Sharma, Rishikrishna, Ghanshyam Yadav, Nitin Tyagi
Abstract
Background: Liver cirrhosis is a chronic disease that leads to multiple complications, including thrombocytopenia and upper gastrointestinal (GI) bleeding. Thrombocytopenia, characterized by a low platelet count, is commonly observed in cirrhotic patients due to hypersplenism and impaired platelet production. Upper GI bleeding, particularly from esophageal varices, is a major cause of morbidity and mortality in these patients.
Objective: This study aims to analyze the correlation between thrombocytopenia and the incidence of upper GI bleeding in patients with liver cirrhosis.
Methods: A cross-sectional study was conducted involving 50 cirrhotic patients admitted to a tertiary care hospital. Platelet counts and clinical parameters were recorded, and upper GI endoscopy was performed to assess the presence of varices and active bleeding.
Results: Statistical analysis revealed a significant association between the severity of thrombocytopenia and the occurrence of upper GI bleeding (p < 0.05). Patients with severe thrombocytopenia (<50,000/µL) exhibited the highest incidence of GI bleeding.
Conclusion: The findings suggest that thrombocytopenia is a strong predictor of upper GI bleeding in cirrhotic patients. Early detection and management of thrombocytopenia may help reduce bleeding-related complications and improve clinical outcomes in this population.
59. A Case Report of Disseminated Potts Disease
Arkanil Das, Anuprabha Bhowmik, Kanak Choudhury
Abstract
Potts spine, also known as tuberculous spondylitis, is a form of extrapulmonary tuberculosis which affects musculoskeletal system. One or more vertebral or intervertebral disc spaces are inflamed due to mycobacterium tuberculosis consequently leading to severe kyphotic deformity and neurologic deficit if there is delay in diagnosis and management. This is a case of 24 years old young male presented with weakness of both lower limbs for 5 days. He had pain in the lower back for last 7 months with difficulty in walking. No history of trauma to the back in the past. This was eventually diagnosed to be potts spine. For diagnosis of potts disease, CEMRI whole spine, IGRA was done. Patient was treated with antitubercular therapy.
60. NIHSS Correlation with Acute Kidney Injury in Ischemic Stroke Patients
Deepti Sharma, Dileep Kumar Mehta, Garv Gupta, Ruchir Jain
Abstract
Introduction: Ischemic stroke (IS) is a major cause of death and disability globally, with acute kidney injury (AKI) being a significant complication in hospitalized stroke patients. The correlation between stroke severity, assessed by the National Institutes of Health Stroke Scale (NIHSS), and the development of AKI remains a critical area of investigation.
Objective: This study aims to explore the relationship between NIHSS scores and AKI in patients with ischemic stroke.
Methods: An observational cross-sectional study was conducted at M.B.S. Hospital, Kota, from December 2022 to December 2023. A total of 67 ischemic stroke patients, confirmed by clinical presentation and CT scan, were enrolled. Renal function tests were performed on admission, at 72 hours, on the 5th day, and at discharge. The NIHSS score was used to assess stroke severity. AKI was defined according to KDIGO criteria and was evaluated in relation to NIHSS scores.
Results: The study population had a mean age of 56.65 ± 8.63 years. Of the participants, 59% were male and 41% were female. The incidence of AKI increased with the severity of the stroke: 16.66% in minor stroke (NIHSS 1-4), 22.72% in moderate stroke (NIHSS 5-15), 61.53% in moderate to severe stroke (NIHSS 16-20), and 100% in severe stroke (NIHSS 21-42). Serum urea and creatinine levels, along with estimated glomerular filtration rate (eGFR), demonstrated significant changes over time, reflecting the progression of AKI.
Conclusion: The study identifies a significant correlation between higher NIHSS scores and increased incidence of AKI in ischemic stroke patients. Higher NIHSS scores, indicative of more severe strokes, are associated with a greater likelihood of developing AKI. These findings emphasize the importance of renal function monitoring in stroke patients, particularly those with higher NIHSS scores, to potentially improve patient outcomes and reduce associated mortality.
61. Anti-Coagulant EDTA Induced Storage Artifacts on Peripheral Blood Smear
Radha Surasetty Angadi, Mamatha R., Girish Kumar B.S., Narayana Murthy C.
Abstract
Background: Changes in blood cell morphology occur easily, even after short periods of time in storage. Microscopic evaluation of a peripheral blood smear is one of the most beneficial tests to identify morphological changes. But anticoagulant-induced artefacts could lead to misinterpretation of the smears. by 24 hours changes become striking. In our study, we will discuss how long EDTA can preserve morphology and determine the best time to preserve blood samples.
Aim: The current study was undertaken to identify the anticoagulant EDTA induced artefacts and thus avoid misinterpretation of peripheral blood smears.
Methods: This study was carried out in haematology laboratory of BMCH, Chitradurga. A total of 80 blood samples were collected from patients who had come to the OPD as a part of routine medical checkup. The blood samples were collected into commercially prepared Tripotassium Ethylene Diamine Tetra Acetic acid [K3 EDTA] vacutainer tubes and were thoroughly mixed and smears were prepared immediately and at 1hr, 2hr, 4hr and 6hr respectively after storing the blood samples at room temperature. Morphological artefacts were studied.
Results: Smears made immediately after addition of anticoagulant did not show any artefactual changes. Smears from EDTA stored blood show significant morphological artefacts on storage.
Conclusion: EDTA has been recommended as the anticoagulant of choice for peripheral smear but should be examined within 1hr of collection to avoid misinterpretation as pathological findings leading to wrong diagnosis.
62. Histopathological Study of Soft Tissue Tumors in Association with Immunohistochemistry
Radha Surasetty Angadi, Girish Kumar B.S., Chandrashekhar T.N.
Abstract
Background: Soft tissue can be defined as non-epithelial, extra skeletal tissue of the body exclusive of reticuloendothelial system, glial and supporting tissue of various parenchymal organs.
[1] Soft tissue tumors are defined as mesenchymal proliferation which occur in the extra skeletal non epithelial tissue of the body, excluding the viscera, coverings of brain and lymphoreticular system. Soft tissue tumors are a highly heterogenous group of tumors that are classified on a basis according to the adult tissue they resemble.
Aim: To study the histopathological pattern for understanding the classification and type of soft tissue tumors. To find out the relative incidence of benign and malignant soft tissue tumors and to classify the soft tissue tumors on the basis of benign and malignant behaviour.
Methods: The test population comprised of patients with soft tissue lesions between May 2018 to December 2019, evaluated by light microscopy and immunohistochemistry.
Results: In the study majority of subjects were in the age group 31 to 40 years (28.4%), has female (59.9%) predominance. First most common soft tissue tumors are lipomatous tumor among all the soft tissue tumors. Most common site is extremities. Lipoma (65.3%) is the most common tumor followed by capillary Haemangioma (6.8%), 88 % were benign lesion, 3.1% were intermediate lesion and 8.5% were malignant lesion. IHC markers were applied to 11 cases to arrive at definite diagnosis.
Conclusion: A good clinical acumen, through description and grossing specimen, and microscopic evaluation of Hematoxylin and eosin stained sections are fundamental aspects in diagnosis of soft tissue tumors. majority of tumors diagnosed by Hematoxylin and eosin stained sections. Immunohistochemistry was done wherever light microscopy was inconclusive.
63. Heart Rate Variability: A Measure of Impaired Autonomic Functions in Offspring of Hypertensive Parents
Vishal Hariramani, Madhu Gupta, Dashrath Ganwani, Kapil Gupta
Abstract
Objective: The objective of the study was to evaluate the Heart rate variability parameters in offspring of Hypertensive and Normotensive parents, so as to detect early impairment of autonomic functions leading to future development of hypertension in offspring of hypertensive parents.
Methods: Cross-sectional observational study. Two groups of offspring of Hypertensive parents and offspring of Normotensive parents (n=60 each) were made. Short-term HRV was measured using 5-minute electrocardiogram (ECG). Unpaired t test was applied to analyze the data with p-value < 0.05 considered as significant and <0.001 as highly significant.
Results: The offsprings of hypertensive parents showed significantly lower values of HF power and SDNN in females. There was significant rise in the values of LFnu and LF/HF ratio in both male and female offsprings of hypertensive parents. Significant fall in values of HFnu, RMSSD, pNN50%, SD1 and SD1/SD2 ratio were observed in both male and female offsprings of hypertensive parents.
Conclusion: There is early dysfunction of vagal modulation in normotensive offsprings of hypertensive parents leading to sympathovagal imbalance and predisposition of future development of hypertension in these persons.
64. A Study of Cervical PAP Smears in a Tertiary Care Hospital, Chitradurga
Radha Surasetty Angadi, Girish Kumar B.S., Murali S.V., Narayana Murthy C.
Abstract
Background: Cervical cancer is one of the major causes of mortality among women worldwide. It has taken fourth place among malignancies that affect women, the first leading is breast cancer. In developing countries including India, it is the leading cause of morbidity and mortality. It is readily preventable and can be diagnosed at the pre invasive stage with adequate and repetitive cytological screening and Papanicolaou smears.
Methods: This is a retrospective study was aimed to screen the patients attending OPD of BMCH, Chitradurga. The main purpose was to study the incidence of premalignant and malignant lesions in population. A total of 564 patients attending OPD of BMCH, Chitradurga were screened during a period of one year from January 2024 to December 2024. Pap smears are taken from women visiting gynaecological OPD between ages of 25 to 70 with different gynaecological complaints using Ayer’s spatula. Smears were reported according to Bethesda system 2014.
Results: A total of 564 pap smears were examined. There were 229 patients with NILM, and 216 patients with inflammatory smear. ASCUS was found in 24 patients, LSIL in 20 patients, HSIL in 10 and squamous cell carcinoma in 01 patient. This study concluded that a simple pap smear test could be offered to vast populations for diagnosing premalignant conditions of the survey this has and will in future continue to aid us with the early diagnosis of survival cancer.
Conclusions: PAP smear is useful in diagnosing malignant and premalignant lesions of the cervix. In developing countries such as India this screening method is cheap and can be widely used. It can be used by trainers and para medical staffs.
65. Evaluation of Facilities at Anganwadi Centers under the Integrated Child Development Services Scheme in Urban Jaipur: A Cross-Sectional Study
Deepak Muraleedharan, Lovesh Saini, Lokesh K Sonkariya, Pooja Jha, Hafis Ahammed A, Dev Kishan
Abstract
Background: Anganwadi Centers (AWCs) under Integrated Child Development Service (ICDS) need safe water, sanitation, storage, and child-friendly spaces. Urban infrastructure gaps hinder service delivery, impacting maternal and child health. Strengthening facilities is key to improving ICDS effectiveness and well-being.
Objective: To evaluate facilities of Anganwadis centers delivered under ICDS scheme in urban Jaipur.
Methods: A cross-sectional study of 85 randomly selected AWCs in urban Jaipur used structured interviews and direct observations. Sampling followed the probability proportionate to size method. Only functional AWCs were included; those without available workers were excluded. Data collection covered infrastructure, services, and resources. Statistical analysis, including Chi-square tests, was conducted using Microsoft Excel and SPSS v26 to assess associations and trends.
Results: Among 85 AWCs, 78% operated from pucca structures, 75.3% were privately owned, and 71.8% had functional toilets. Electricity access was high(91.8%), but water supply varied(71.8%). Immunization and nutrition records were well-maintained(95–98%), while health check-up compliance was lower(73–88%). Essential medicines were widely available, staffing was adequate(93%), and 96% of workers reported skill enhancement. Jaipur-3 and Sanganer City had better infrastructure, with over 90% of AWCs having water and toilets. Water supply(p=0.047) was lowest in Jaipur 2(54.5%) and highest in Sanganer City(90.9%). Toilet availability (p=0.039) was lowest in Jaipur 1(61.1%) and highest in Sanganer City(90.9%), averaging 72.9%.
Conclusions: Study highlights disparities in infrastructure, sanitation, and resource availability among Anganwadi Centers in Jaipur. While electricity access and record maintenance were adequate, gaps in water supply, sanitation, and storage persist.
66. A Study on the Prevalence of Hypomagnesemia in Hyponatremic Patients with Acute Heart Failure and Its Prognostic Value
Nikitha K., Arun S. Menon, Riyas C.
Abstract
Background: Magnesium is a crucial intracellular cation involved in numerous physiological processes, including cardiac electrophysiology and cellular bioenergetics. Hypomagnesemia, characterized by a serum magnesium level below 1.8 mEq/L, is common in hospitalized patients, particularly those with heart failure. Hyponatremia, the most frequent electrolyte disturbance in hospitalized patients, is associated with increased morbidity and mortality in heart failure. The interplay between hypomagnesemia and hyponatremia in heart failure patients is not well understood. This study aims to determine the prevalence of hypomagnesemia in heart failure patients with hyponatremia and evaluate its impact on patient outcomes, including mortality, hospital stay, readmissions, and complications.
Methods: This observational study was conducted at Malabar Institute of Medical Sciences, Calicut, Kerala, from March 2019 to March 2020. A total of 150 patients admitted with heart failure and hyponatremia were enrolled. Patients were categorized into two groups based on their serum magnesium levels: Group A (hypomagnesemia, Mg <1.8 mg/dL) and Group B (normomagnesemia, Mg ≥1.8 mg/dL). Data on demographic characteristics, comorbidities, electrolyte levels, length of hospital stay, readmissions, mortality, and complications were analyzed using SPSS 17.0.
Results: Hypomagnesemia was prevalent in 44.67% of heart failure patients with hyponatremia. The mean age was comparable between the two groups (68.35 ± 10.72 years in Group A vs. 67.28 ± 11.70 years in Group B). A significant male predominance was observed in hypomagnesemic patients (63.5% vs. 36.5%, p=0.020). The length of hospital stay was significantly longer in the hypomagnesemic group (8.03 ± 6.436 days vs. 6.27 ± 4.518 days, p=0.046). Mortality rates were not significantly different between the groups (12.7% in Group A vs. 16.09% in Group B, p=0.562). The incidence of readmissions was similar (36.51% vs. 39.08%, p=0.749). Common complications included acute kidney injury (34.72% in Group A vs. 48.91% in Group B), cardiac arrhythmias (29.16% vs. 25%), infections (8.33% vs. 5.43%), and thrombotic events (6.94% vs. 3.26%).
Conclusion: Hypomagnesemia is common among heart failure patients with hyponatremia, affecting nearly 45% of cases. While hypomagnesemia was associated with prolonged hospital stays, it did not significantly impact mortality, readmissions, or complication rates. Further large-scale studies are required to assess the prognostic significance of hypomagnesemia in heart failure patients.
67. Myopia Among Children and Adolescents: An Observational Study at Tertiary Care Center in Kumaon Region, Uttarakhand
Himani Jailkhani, Prateek Koul, Ininaki Lyngdoh, Garima Chunera
Abstract
Objectives: The present study was to evaluate the prevalence of myopia in children and adolescents in Kumaon region of Uttarakhand, India.
Methods: General data regarding the age, sex, address, history related to refractive error was collected by interviewing the child and parent, followed by entering the information taken in the pre-tested semi- structured questionnaire by the investigator, followed by the screening of vision of the child. A short counselling supported by charts, posters and audio-visual tapes regarding eye health education was given to children after general and ophthalmic examinations.
Results: A total of 200 children with age group 5 to 15 years were visited to Ophthalmology OPD for eye related problem. Among them, most of the cases (58%) were in age group of 5 to 8 years. 29.5 % cases were in age group of 9 to 11 years. Most of the children 124(62%) were boys. 76(38%) were girls. Hence, rate of prevalence of myopia in male child was 21.77% and female child was 22.37%. And it was not statistically significant (p=0.921). Among myopic children, mild myopia was seen in 23(52.27%) children. Moderate myopia was seen in 16(36.36%) children and severe myopia was seen in 5(11.36%) children.
Conclusions: Overall, rate of prevalence of myopia is 22%. Myopia is greatly seen in primary and secondary school children. Mild myopia is commonly seen in more than half population of myopic children. Many factors such as increased indoor activities, lack of daylight exposure, particularly in view of increased use of digital media refractive error should be considered at early ages so that the Myopia can be timely diagnosed and treated. Hence, we should organise ophthalmology check-up camp in school time to time for awareness and early detection of myopia.
68. Clinico-Pathological Assessment of Lymphomasata Tertiary Care centre- Based on latest WHO classification of lymphoid neoplasms
Vani D, Pavan Kumar M, Zashank S Joshi, Roopashree G
Abstract
Introduction: Lymphomas are heterogeneous group of malignancies prevalent in developed countries. They arise from clonal proliferation of B cell, T cell and Natural Killer (NK cell) subtypes of lymphoid population at different stages of maturation. Lymphomas are broadly classified into non-Hodgkin lymphoma ( NHL) and Hodgkin lymphoma (HL) by WHO.
Aims and Objectives: (1) To analyse the frequency of various lymphoma satatertiary care hospital in India. (2) To correlate clinical and radiological data with pathological features according to latest WHO classification of lymphoid neoplasms.
Materials and Methods: Overall cases of lymphoma as were retrospectively assessed over a period of two years and categorised according to latest WHO classification of lymphoid neoplasms based on historical morphology and immunohistochemistry (IHC) results. Clinical and radiological data were correlated with pathological findings.
Results: Total 43 proven cases of lymphomas were recorded in the present study, out of which 33 cases (77%) were reported as Non-Hodgkin’s lymphoma and 10 cases (23%) we’re reported as Hodgkin’s Lymphoma. Among Non-Hodgkin’s lymphoma, DLBCL was found to be most common subtype accounting for 42% followed by follicular lymphoma (12%), Marginal zone lymphoma including MALT lymphoma (9%), T cell lymphoma (7%), mantle cell lymphoma (5%) and Small lymphocytic lymphoma accounting for 2%. Among Hodgkin’s lymphoma, Mixed cellularity was the most common subtype accounting for 14% followed by lymphocyte rich type (7%) and 2% of nodular sclerosis variant were reported.
Conclusion: Incidence of NHL is higher compared to HL. Follicular lymphomas are lower compared to western studies with DLBCL being the most common subtype of NHL. Mixed cellularity is the most common subtype of HL unlike nodular sclerosis subtype in Western world.
69. Prevalence of Bacterial Contaminants in Pathology, Microbiology and Biochemistry Laboratory Environments and Their Reduction after Disinfection: A Cross-Sectional Study
Jayashree Konar, Jayita Dasgupta Ghosh, Sambit Dasgupta
Abstract
Background: Laboratory environments are potential reservoirs of bacterial contamination, posing risks of cross-contamination and laboratory-acquired infections. This study aimed to determine the prevalence of Pseudomonas spp., Bacillus spp., Escherichia coli, Klebsiella spp., Staphylococcus aureus, and Coagulase-Negative Staphylococci (CoNS) in Microbiology and Biochemistry laboratories after daily work sessions and to assess the effectiveness of routine disinfection.
Methods: A total of 50 surface swabs were collected from laboratory workstations before and one hour after disinfection with 1% sodium hypochlorite and 70% ethanol. Bacterial isolation was performed using standard microbiological techniques, and statistical significance was analyzed using the Chi-square test.
Results: Among 50 swabs collected post-session, bacterial contamination was as follows: Pseudomonas spp. (18%), Bacillus spp. (22%), E. coli (12%), Klebsiella spp. (10%), S. aureus (16%), and CoNS (22%). However, no bacterial growth was observed one hour after disinfection (p < 0.001, statistically significant).
Conclusion: A significant bacterial load was detected after daily work sessions, with Bacillus spp. and CoNS being the most frequently isolated. The absence of bacterial growth after disinfection confirms the efficacy of routine cleaning protocols. Maintaining rigorous disinfection practices is crucial in minimizing laboratory contamination and ensuring biosafety.
70. Outcome of High Flow Nasal Oxygen (HFNO) Therapy in Children with Acute Bronchiolitis at a Tertiary Care Centre
P A Sathya, S Kalpana, K Velmurugan, R V Dhakshayani, M S Aishweryaabbirami, M Thenmozhi, S Ezhilarasu
Abstract
Bronchiolitis affects a vast number of young children less than 2 years of age, mandating hospitalisation of a significant percentage of affected children. Oxygen therapy has been a cornerstone in the management of such children, and the oxygen delivery devices have undergone a revolution. This Open labelled randomized control study was conducted in GVMCH on 150 children to determine the outcome in terms of clinical improvement and the need for escalation and de-escalation of Oxygen therapy. Early initiation of HFNC Oxygen therapy in children with bronchiolitis proved to be more effective than standard Oxygen therapy in reducing the duration of Oxygen treatment, hospital stay and the need for invasive Mechanical Ventilation with minimal side effects.
71. Plasmid Curing of Pseudomonas spp. Using Lugol’s Iodine: Reversal of Carbapenem Resistance by Phenotypic Methods
Jayashree Konar, Moumita Adhikary, Sujay Mistri
Abstract
Background: Carbapenem-resistant Pseudomonas spp. are a major concern in hospital-acquired infections, particularly in intensive care units (ICUs). Plasmid-mediated resistance contributes significantly to their multidrug-resistant nature, limiting therapeutic options. Plasmid curing, which involves eliminating resistance-carrying plasmids, is a potential strategy to restore antibiotic susceptibility. This study investigates the effectiveness of Lugol’s iodine in plasmid curing and the subsequent phenotypic reversal of carbapenem resistance.
Methods: This experimental study was conducted over two months in a tertiary care hospital in West Bengal. A total of 20 carbapenem-resistant Pseudomonas spp. isolates were obtained from ICU (n=15), Medicine ward (n=3), and Surgery ward (n=2). Specimens included urine (n=9), lower respiratory tract samples (n=8), and wound swabs (n=3). Plasmid curing was attempted using Lugol’s iodine, and phenotypic restoration of carbapenem susceptibility was assessed.
Results: Successful plasmid curing was observed in 11 out of 20 isolates (55%). The highest number of isolates was from urine (45%), followed by lower respiratory tract samples (40%) and wound swabs (15%).
Conclusion: Lugol’s iodine demonstrated promising plasmid-curing activity, reversing carbapenem resistance in over half of the isolates. Further molecular studies are needed to confirm its potential clinical application.
72. Recurrence Pattern and Survival in Patients with Carcinoma Cervix Treated in Tertiary Hospital: A Five Year Follow Up
Pandi Durai M, Ingersol N
Abstract
Introduction: In India carcinoma cervix is 2
nd most common cancer among women, most common among rural population and major cause of cancer death in this population. Prevalence of cervical cancer in rural and socioeconomic weaker section is attributed to lack awareness and less access to screening programme. In this retrospective study we have analysed different treatment modality for early and locally advanced carcinoma cervix, pattern of recurrence, 5 year the disease free and overall survival from our institute.
Materials and Methods: Histologically proven carcinoma cervix with FIGO stage (2009) I A to IVA treated between the year January 2014 to December 2014 in Government Royapettah hospital Chennai were retrospectively analysed with respect to initial workup, primary modalities of treatment, like surgery, concurrent chemoradiation, disease outcomes, follow up, disease recurrence patterns, secondary interventions and treatment modalities and followed up till January 2024.
Results: A total of 265 patients with carcinoma cervix were registered in January 2014 to December 2014, of which 230 were non-metastatic disease and analysed for the study. Median age at diagnosis was 50 years. 81.4% were above the age of 40 years, majority of the patients 174(75.4%) were in locally advanced stage (stage IIB-IVA). Among stage of disease IIB (37.4%)>IIIB (22.6%)>IVA (12.6%). Squamous cell carcinoma was the common histology (64.8%). Pattern of recurrence for early stage was loco regional on vaginal stump. DFS at 5 years was 64.3% and OS at 5 years was 73.2%. Pattern of recurrence in locally advanced disease was local in 30.4%, nodal in 12.7% and progression during treatment in 13.7%. Among distant recurrence lung (14.9%), left supraclavicular in (13.2%). DFS at 5 years for 32.6% and OS at 5 years was 34.1%.
Conclusion: From this study we conclude early stage carcinoma cervix had better disease free survival and overall survival compared to locally advanced disease. Addition of neoadjuvant chemotherapy in locally advanced disease did not improve DFS or OS.
73. Prevalence and Antibiotic Patterns of Urinary Tract Infections among Post-Menopausal Women
Vikas Gupta, Jini Gupta
Abstract
Objective: To investigate the prevalence, antimicrobial resistance patterns, and the influence of menopausal status on urinary tract infections (UTIs) in postmenopausal women aged 45 years and older.
Method: A prospective cohort study was conducted on 127 postmenopausal women with confirmed UTIs. Urine samples were collected and processed following the Clinical Laboratory Standards Institute (CLSI) guidelines. Bacterial isolates were identified, and antibiotic susceptibility testing was performed using the VITEK-2 automated system. Resistance patterns were classified into multidrug-resistant (MDR), extensively drug-resistant (XDR), pan-drug-resistant (PDR), monodrug-resistant (MoDR), and MultiS (susceptible to all antibiotic classes). Data were analyzed statistically to assess the relationship between menopausal status and antimicrobial resistance trends.
Result: Among the female participants, 53% were postmenopausal women. E. coli was the predominant uropathogen, isolated in 69% of the cases, followed by Klebsiella (12%) and Enterococcus (7%). Resistance to ampicillin (83%), amoxicillin/clavulanic acid (82%), and cefazolin (71%) was notably high. Nitrofurantoin demonstrated the lowest resistance rate (10%), followed by colistin (5%) and fosfomycin (8%). MDR, XDR, and PDR rates among all isolates were 33%, 9%, and 2%, respectively, with E. coli and Klebsiella showing the highest resistance.
Conclusion: This study highlights the high prevalence of UTIs and antimicrobial resistance among postmenopausal women, particularly against commonly used antibiotics. The findings underscore the urgent need for targeted antibiotic stewardship programs and the development of tailored treatment guidelines. Further research is essential to explore the interplay between menopausal hormonal changes and resistance patterns.
74. Pain Relief in Proximal Femur Fracture Patients Between USG Guided Fascia Iliaca Compartment Block Versus USG Guided Femoral Nerve Block: A Randomized Controlled Study
Madhuri Deelip Tayade, Upendra Kanzarkar, Amit Hiwarkar
Abstract
Background: The fractures of the proximal femur, fracture of the neck of femur, intertrochanteric and subtrochanteric fractures, are the most common orthopaedic emergency among geriatric population. Pain associated with these injuries makes appropriate positioning difficult for the regional anaesthesia, various nerve blocks have been tried to reduce preoperative pain to facilitate proper positioning and to reduce postoperative pain. The present study aimed to compare pain relief in proximal femur fracture patients between USG guided fascia iliaca compartment block versus USG guided femoral nerve block at tertiary care hospital.
Material and Methods: The present randomized control study was conducted in Department of Anaesthesiology at Government Medical College and Hospital. The sample size for the study was of 90 adult posted for elective surgery for fracture proximal femur randomly allocated into two groups, 1st with USG guided FICB and 2nd with USG guided FNB. Study was started only after approval of the ethics committee. USG guided peripheral nerve block given and data collection was done. Baseline vitals (HR, BP, SpO2) and VAS Score for pain assessment before the block in patients resting position (supine) and sitting position was assessed. The software used in the analysis was SPSS 24.0 version.
Results: The mean VAS score in supine and sitting position among group-1 and among group-2 were not statistically significant. After block administration in participants [supine position] with respect to VAS score there was significant difference at 5, 10, 15 and 20 min between both groups (i.e., p < 0.05). At the time of spinal anaesthesia administration in sitting position, mean heart rate, Mean Systolic blood pressure, mean VAS score of participants in group-2 was significantly better than group-1 (i.e., p = 0.003, p = 0.010 & p=0.006) respectively.
Conclusion: The present study concludes that FNB holds considerable promise as an effective analgesia for positioning during spinal anaesthesia administration compared to FICB.
75. Clinico-Histological Correlation of Lesions in Urinary Bladder: Insights from Biopsy Analysis
Vani D, Rakshitha R, Vidya Vasudev, Mohammed Azm Shameel, Rohan Dayanand
Abstract
Background: Urinary bladder diseases, encompassing both neoplastic and non-neoplastic lesions, are commonly encountered in clinical practice. With bladder cancer now recognized as the seventh most prevalent cancer globally and its incidence on the rise, the need for effective diagnosis and management is crucial. This study focuses on examining the clinicopathological features of various bladder lesions, with a particular emphasis on grading. The goal is to mitigate the morbidity and mortality associated with urinary bladder cancers through improved understanding and early intervention.
Aim: To study the histopathological spectrum of bladder lesions, highlighting their frequency and distribution across age and gender groups.
Materials and Methods: The present study was two year analysis of biopsies of urinary bladder received in Department of pathology, Mysore medical college and research institute, Mysore from July 2022 to June 2024. A detailed clinical history was taken from the patient. A total of 128 cases were included who has undergone transurethral resection of bladder tumour/ cystoscopic biopsies were included in the study. Biopsy specimens with autolysis or inadequate tissue for histopathological evaluation were excluded.
Results: In the study group, the majority of patients belonged to the 61–70 years age group. The most commonly reported symptoms included lower urinary tract issues, with haematuria being the most frequent, followed by increased frequency of micturition, burning micturition, dysuria, and abdominal pain. Out of 128 cases, 122 were neoplastic and 6 were non neoplastic lesions.
Conclusion: Bladder tumours are well-known for their high recurrence rates, rapid advancement to high grade, and the challenge posed by their non-specific symptoms. This makes precise diagnosis essential, with cystoscopy and histopathological analysis of biopsy material being pivotal in guiding treatment.
76. Effect of Yoga Nidra Practice on Sleep Quality in Medical Students
Itika Singh, Swati Chouhan, Ashutosh Kumar, Shyam Sunder Nagpal
Abstract
Introduction: Medical students have greater academic load that can contribute to poor sleep quality. It is significant to know whether they have sleep problem, extent of problem and whether sleep disturbances have any effect on academic performance or quality of life. Yoga Nidra is a branch of Yoga; meaning psychic sleep, that is, sleep with full sense of awareness. Main principle behind Yoga Nidra is deep relaxation of mind.
Material and Method: The study was conducted in Physiology department, WCMSRH, Jhajjar, Haryana. Study group comprised of 30 medical students who practiced Yoga Nidra for 02 months for 45 minutes daily at evening time. Sleep quality was assessed by Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale, before and after Yoga Nidra practice.
Observation: Pittsburgh Sleep Quality Index: There was improvement in time of going to bed, minutes taken to fall asleep, morning getting up time and sleep hours per night after Yoga Nidra. Bad dreams and snoring during sleep got improved after Yoga Nidra.
Epworth Sleepiness Scale: After Yoga Nidra, chances of dozing while sitting and reading, sitting and talking to someone and watching TV while sitting as passenger in a car for an hour or more without stopping for a break were reduced and they would never doze in these situations.
Discussion: Medical students appear to be vulnerable to poor sleep, due to long duration, high intensity studies and clinical duties that can be emotionally challenging. In Yoga Nidra, body sleeps but mind remains awake. One month practice helped in improvement of sleep quality as evident by outcomes of parameters in sleep scales.
Conclusion: Our study revealed that overall psychological and physical outcome associated with health of medical students got improved after Yoga Nidra. Yogic intervention improves academic performance by reducing stress. Long term follow-ups are needed to optimize health safety and efficiency of our budding medical practitioners.
77. Prevalence of undernutrition and its Associated Factors among Anganwadi Children in Ernakulam District
Anu Issac, Rose Tresa George, Ganesh Mohan, Shiji K. Jacob
Abstract
Background: Undernutrition is a leading cause of morbidity and mortality among children worldwide. Its health effects include stunted physical growth, impaired motor and cognitive development, lower IQ, poor social skills, increased behavioral issues, and heightened susceptibility to infections.
Objectives: To determine the prevalence of Undernutrition in Anganwadi children among Ernakulam district during the study period and to identify the various sociodemographic factors associated with undernutrition in study groups.
Methods: A descriptive cross – sectional study was conducted among 300 children between 3 to 6 years of age attending anganwadis in Ernakulam district selected by multistage cluster sampling. Anthropometric measurements were recorded after obtaining informed consent and completing a predesigned questionnaire. Data were analyzed using Anthrocal and SPSS software. Quantitative variables were expressed as mean and standard deviation (SD), while categorical variables were presented as frequency and percentage. ANOVA was used to test the statistical significance of difference between means of variables among different independent groups. Pearson Chi-square test was used to compare categorical variables between groups.
Results: In our study, wasting was present among 14.7%, underweight 19.7% and stunting among 33% of the study population. The factors associated with underweight were mother’s occupation, vaccination status of child, birth weight of child and poor nutrition.
Conclusion: The prevalence of underweight, stunting and wasting was notably high among the population under study. While mother’s occupation, vaccination status of child, birth weight of child, 24-hour calorie and protein intake, were factors associated with underweight, vaccination status of child, 24-hour calorie and protein intake were associated with wasting and stunting in children.
78. Association of Vasomotor Symptoms with Cardiovascular Risks in Peri Menopausal and Menopausal Women
Mamta Gangwal, Rekha Jharwal, Rajani Meena
Abstract
Background: Perimenopause and menopause often involve vasomotor symptoms (VMS), notably hot flashes and night sweats, which arise from shifting hormonal levels—especially estrogen. Current evidence proposes that VMS may also signal an elevated risk of cardiovascular disease (CVD). Since cardiovascular conditions are a principal cause of death in post-reproductive women, understanding the link between VMS and cardiovascular risk is of great clinical importance.
Methods: A cross-sectional investigation was carried out with women aged 45–60 years in perimenopausal or postmenopausal stages. Each participant completed a questionnaire on the presence and intensity of VMS. Standardized measurements, including blood pressure, lipid profiles, fasting glucose, and body mass index (BMI), and were compiled to gauge cardiovascular risk. Statistical analyses such as correlation and regression were performed to explore the relationship between VMS severity and cardiovascular markers, adjusting for variables like age and smoking.
Results: Women experiencing moderate-to-severe VMS presented with higher systolic blood pressure, low-density lipoprotein (LDL) cholesterol, and fasting glucose than those reporting mild or no VMS. The observed correlations persisted after controlling for lifestyle parameters, indicating a potential direct link. Night sweats occurring multiple times per week were associated with increased likelihood of developing metabolic syndrome.
Conclusion: These findings imply that VMS might serve not just as a menopausal quality-of-life issue but also as a potential indicator for heightened cardiovascular risk. Prompt recognition and integrated management of VMS and associated risk factors could decrease long-term cardiovascular complications for women in midlife and beyond.
79. Low-Dose Mifepristone versus Levonorgestrel Intrauterine System (LNG-IUS) QIN the Medical Management of Adenomyosis
Mamta Gangwal, Rajani Meena, Ankita Kasliwal
Abstract
Background: Adenomyosis involves the migration of endometrial tissue into the myometrium, commonly resulting in menorrhagia, pelvic discomfort, and an enlarged uterus. In clinical practice, conservative strategies target symptom control, fertility preservation, and avoidance of surgical intervention. Low-dose mifepristone and the levonorgestrel intrauterine system (LNG-IUS) are two prominent non-surgical modalities.
Methods: In this prospective, parallel-group trial, 80 premenopausal women (ages 30–50) diagnosed with adenomyosis via clinical assessment and ultrasound were randomly allocated to receive either oral mifepristone (5 mg/day) or LNG-IUS placement over six months. Primary outcomes included changes in uterine dimensions, dysmenorrhea severity (rated by a visual analog scale), and menstrual blood loss. Secondary measures comprised hemoglobin levels, quality of life indices, and adverse effect profiles.
Results: Seventy-four participants finalized the study, with 37 in each group. Both treatments effectively reduced uterine volume by the six-month endpoint (p<0.05) without any significant difference between the two cohorts. Menstrual pain scores showed substantial reductions across both groups (p<0.01), and final pain ratings did not differ significantly between them at six months. Although LNG-IUS use led to a quicker initial reduction in menstrual flow, final bleeding patterns after six months were comparable in both arms. Each group also exhibited improved hemoglobin levels and enhanced quality of life. Adverse events were generally mild, with one case of device expulsion reported.
Conclusion: Low-dose mifepristone and LNG-IUS demonstrated parallel effectiveness in managing adenomyosis symptomatology—reducing uterine bulk, alleviating pain, and mitigating heavy menstrual bleeding. While the LNG-IUS group achieved an earlier reduction in bleeding volumes, both methods produced comparable outcomes at the study’s conclusion. These findings suggest that either approach is a reasonable conservative option for individuals desiring non-surgical management of adenomyosis.
80. A Study on the Correlation of Hemoglobin and Iron Levels between Mother and Newborn in a Teaching Hospital of Bihar
Nand Kishor Singh, Vivek Ranjan, Mohammed Shamim, Bir Prakash Jaiswal, Akhilesh Kumar
Abstract
Background: Mean cord hemoglobin concentration is approximately 17gm/dl and values below 14gm/dl are considered abnormal, after 35 week of gestation. Amount of iron diverted to foetus is similar in a normal and in iron deficient mother. The new-born iron stores are related to maternal iron status and timing of cord clamping. Whether a maternal dietary iron transfer to the foetus is related to maternal iron status is still debated. Previous studies on the relationship between maternal and neonatal iron status using multiple parameters showed contrasting results. Estimation of hemoglobin of neonates from cord blood is useful in diagnosing neonatal anemia.
Aim: (1) To study the impact of maternal hemoglobin on cord blood hemoglobin of newborn. (2) Observe correlation between maternal and new-born iron levels and to correlate the effect of maternal hemoglobin levels with birth weight of newborns.
Study Site: Study was carried out at Nalanda Medical College & Hospital, Patna.
Study Population: Pregnant mothers attending the labour room at Nalanda Medical College & Hospital, Patna and their babies delivered were included in the study.
Study Design: Cross sectional study.
Study Period: One year (January 2024 to December 2024).
Results: The cross sectional study was conducted on 200 mother newborn pairs. Cord blood hemoglobin and maternal hemoglobin was compared. The mean maternal hemoglobin level was 10.52±1.74, for anemic mother it was 9.18±1.34, and for non anemic mothers it was 11.89±0.76. 31.68% mothers had mild anemia, 58.42% mothers had moderate anemia whereas only 9.90% study mothers had severe anemia. The mean serum iron in mothers was 108.06±37.19. The mean cord blood hemoglobin were 15.55±1.35 and mean cord blood iron level was 148.69, SD- 36.00. Mean cord hemoglobin between anemic and non-anemic mothers were compared and the difference between them was statistically significant with p<0.01. The mean cord hemoglobin among the three groups (mild, moderate, severe) were compared with mean cord hemoglobin of the non-anemic group. The difference between the groups were statistically significant with P values <0.01, <0.01 and <0.01 respectively.
Conclusion: Maternal anemia has a significant impact on the hemoglobin status of the newborn. There was significant difference found between mean cord hemoglobin of newborns from anemic mothers that with newborns from non-anemic mothers.
81. Scalp Reconstruction with Novel Unopposing Double Hatchet Flaps- A Case Series
Prasanta Kumar Bal, Deepti Swain, Abhinash Sahoo, Pruthwiraj Singh
Abstract
While there are regional and distant methods for reconstructing acquired scalp defects, the use of local flaps consistently preserves the scalp’s topography. The selection of a local flap for scalp wound covering, similar to the treatment of any other defect, is determined by the defect’s location, size, depth, and the availability of neighboring tissue for rebuilding. The flexible triangular hatchet flap with a partial skin and subcutaneous bridging pedicle exhibits significant adaptability. When used alone or in pairs to address tiny and medium-sized faults, using both rotational and translational movements, it preserves the visual look. Double hatchet flaps are often used in an opposing fashion to transform a circular incision into a ‘S’ shaped suture line. In this case series, the authors describe four representative cases and present a modification of the double hatchet flap in an unopposing configuration, rather than an opposing pattern, to address scalp defects when the type and extent of injury precludes the use of flaps positioned 180 degrees apart. Authors assert that this approach enhances the developing repertoire of reconstructive surgeons and may be used in the specified scenarios when conventional methods are inadequate for covering moderate-sized scalp deformities.
82. Evaluating Risk Factors, Clinical Presentation and Angiographic Outcomes in Left Main Coronary Artery Stenosis
Jain Pramesh, Goel Ankur, Namdev Hemant, Gupta Piyush, Kurmi Pradeep
Background: Patients with left main coronary artery (LMCA) disease often present with variable angiographic findings, posing significant challenges in diagnosis and treatment. Therefore, we aimed to evaluate the risk factors, clinical presentation, and angiographic outcomes in patients with LMCA stenosis.
Methods: This prospective, observational study included 36 patients who underwent coronary angiography between January 2023 to December 2023 at a Tertiary care centre in central India and were diagnosed with LMCA disease. Patients were categorized into obstructive (>50% stenosis) and non-obstructive (≤50% stenosis) LMCA disease groups. Comprehensive clinical evaluations, including coronary angiography, were performed among the patients.
Results: Of the 36 patients, 12 (33.3%) had obstructive LMCA disease and 24 (66.7%) had non-obstructive LMCA disease. Elderly patients (50-60 years) had more prevalence (58.3%) of LMCA stenosis. Diabetes (61.1%), hypertension (52.7%), and smoking (47.2%) were the most prevalent risk factors. Unstable angina was the most common clinical presentation (72.2%) followed by stable angina (22.2) and ST-elevation myocardial infarction (STEMI) (5.5). Triple vessel disease was observed in 72.2% of patients, and distal bifurcation lesions were most common (66.6%). All patients with obstructive LMCA disease showed ST-segment elevation in lead aVR on electrocardiogram. In-hospital outcomes for obstructive LMCA disease patients included cardiogenic shock and heart failure (41.6% each), with no death or post-procedure complications. Non-obstructive LMCA patients experienced no adverse events.
Conclusion: This study identified smoking, hypertension, and diabetes as key risk factors for LMCA disease. Unstable angina was frequently associated with LMCA disease. Triple vessel involvement and distal bifurcation lesions were common. Obstructive LMCA disease was linked to severe complications such as cardiogenic shock and heart failure.
DOI: 10.5281/zenodo.
83. A Study to Compare Efficacy of Two Different Venous Occlusion Duration of Pretreatment with Injection Lignocaine on Pain Due to Injection Propofol in Patients Undergoing Surgery Under General Anaesthesia
Kinjalben Patel, Swapnali Suryawanshi, Ashish P. Jain, Akhilesh Chhaya
Abstract
Introduction: Propofol is widely used in general anesthesia, though its administration is often associated with pain at the injection site. This discomfort can hinder the overall patient experience and recovery. Various methods have been explored to mitigate this pain, with pre-injection treatment using local anesthetics such as lignocaine being particularly notable. Understanding the optimal duration for venous occlusion during this pretreatment can aid in clinical practice.
Aim: To study the effect of two different durations of venous occlusion under a tourniquet in preventing propofol injection pain with pretreatment using lignocaine.
Objectives: 1. To determine the incidence of propofol injection pain with pre-treatment using lignocaine. 2. To assess the severity and grading of pain using the McCririck and Hunter pain scale.
Materials and Methods: This prospective, randomized controlled study involved 100 patients of both genders, scheduled for elective surgeries under general anaesthesia. Participants were divided into two groups (Group L30 and Group L60), each consisting of 50 patients. Group L30 received Injection Lignocaine 40 mg intravenously with venous occlusion for 30 seconds, while Group L60 received the same dose under occlusion for 60 seconds. Pain was assessed after administering 25% of the total calculated dose of propofol. Preoperative assessments included checking for lignocaine sensitivity and investigating general fitness for anesthesia, followed by appropriate premedication and monitoring during the procedure.
Results: The study revealed that significantly more patients in Group L30 (70%) reported pain compared to Group L60 (36%), with a statistically significant p-value of < 0.05. Among those who experienced pain in Group L30, 60% reported mild pain and 10% moderate pain. In contrast, Group L60 revealed that 34% experienced mild pain and 2% reported moderate pain.
Conclusion: The findings indicate that pretreatment with Injection Lignocaine 40 mg under venous occlusion for 60 seconds leads to a significantly lower incidence.
84. Study of Head and Neck Lesions Diagnosed On Fine Needle Aspiration Cytology in a Tertiary Care Hospital
Rohini B., Raja Pramila G., Pavitra K., Praveena T., Monica M.
Abstract
Background: In clinical practice, we often encounter head and neck lesions requiring careful consideration and management. Fine needle aspiration cytology serves a crucial part in diagnosing these conditions due to the convenient accessibility of aspiration. When distinguishing between neoplastic and non- neoplastic etiologies, FNAC is essential, enabling clinicians to make informed decisions regarding patient management.
Aim: The study aims to assess the role and usefulness of FNAC in diagnosing lesions of the head and neck.
Materials and Methods: This is a prospective descriptive cross-sectional study conducted over eighteen months, utilizing FNAC at GITAM Institute of Medical Sciences and Research, Visakhapatnam.
Results: A total number of 234 cases of head and neck lesions were evaluated. The most common age group encountered was 31-40 years with 38% of cases. Predominant cases were females 65.3% when compared to males 34.7%. The thyroid gland was the predominant site observed in 104 cases (44.4%) followed by the lymph node in 93 cases (41%). Thirteen cases (5%) were observed in the salivary gland. Skin and soft tissue cases were fifteen (6%) and nine cases (3.6%) were seen in the oral cavity. In a total of 234 cases there were 112 (47.9%) cases of non-neoplastic etiology, 117 (50%) cases pertaining to neoplastic etiology and five cases (2.1%) were indeterminate. Out of 117 neoplastic lesions, 102 (87.1%) were benign and 15 (12.9%) were malignant.
Conclusion: FNAC serves as a straightforward, quick economical and minimally invasive technique. This study has determined that it can distinguish between non-neoplastic and neoplastic etiologies which contributes to the avoidance of unnecessary surgery and aids in the selection, guidance and adaptation of surgical planning for patients who need surgical procedures.
85. A Study of Knowledge, Attitude and Practice of Generic Medicines among Medical Practitioners at Tertiary Care Teaching Hospital
Riya J. Master, Yagnik A. Vaghasia, Ruchita J. Mer, Madhav D. Trivedi, Tejas A. Acharya
Abstract
Background: US Food and Drug Administration (FDA) defines generic drug as “a drug product that should have the same active ingredient, strength, dosage form, route of administration, quality, performance characteristics, and intended use as the brand-name drug”. Prescription of generic drugs when clinically appropriate can reduce costs without reducing quality.
Aim and Objectives: Aim of this study was to assess knowledge, Attitude and Practices of Generic Medicine among medical practitioners of tertiary care teaching hospital.
Materials and Methods: A prospective observational questionnaire-based study was conducted after approval by Institutional Ethics Committee. Pre-validated Questionnaires based online google form about Generic Medicines was sent to 80 medical practitioners. Among them 78 Medical Practitioners voluntarily participated in the study. Data collected through Medical Practitioner’s responses in the google form and analyzed by using Microsoft Excel sheet.
Results: 80% Medical Practitioner believed that Brand name medicines are copy of Generic name medicine. 82% Medical Practitioner believed that Generic Medicines are therapeutically equivalent than Brand name medicines. 45% Medical Practitioner believed that Brand name medicines produce lesser side effects than generic medicines. 56% Medical Practitioner prescribed Brand name medicine when Generic Medicine are available. 30% Medical Practitioner think that there should be a generic medicine store at every government hospital.
Conclusion: However, Medical Practitioner had good knowledge and perception towards Generic medicine but there is a need to conduct Awareness Programs, Continuing Medical Education (CME), Workshops and Conferences to improve knowledge about the Generic Medicine. So that would increase the use of generic drugs which ultimately would reduce healthcare expenditure.
86. A Study on Assessment of Awareness about Fixed Dose Combinations (FDCS) Among Medical Practitioners in Gujarat State
Yagnik A. Vaghasia, Riya J. Master, Ruchita J. Mer, Sunita B. Chhaiya, Tejas A. Acharya
Abstract
Background: Fixed-Dose Combinations (FDCs) of medications are increasingly prevalent in the Indian pharmaceutical market. However, the irrational prescribing of FDCs poses a significant public health concern. To address this issue, it is essential for healthcare professionals to promote awareness, ensure they remain up-to-date with the latest developments and adhere to rational prescribing practices. The possessing comprehensive knowledge, adopting appropriate attitudes, and engaging in prudent practices are crucial for optimal daily clinical practice across all health care settings.
Aim: Aim of this study was to assess the knowledge attitude, and practices of Fixed Dose Combinations (FDCs) among medical practitioners in Gujarat.
Methods: This prospective observational study (IEC approved) surveyed 219 medical practitioners across Gujarat using a pre-validated online questionnaire (Google Forms). The survey was completed by 218 respondents, and data were analysed as frequencies and percentages.
Results: Out of 218 participants, only 17% believed that there is sufficient regulation and oversight of FDCs in India. 16.5% believed that prescription is necessary to avail FDCs from pharmacies. 50.9% never checked rationality before prescribing any FDCs. Participants gained knowledge about FDCs mainly through random internet surfing (60.1%) and from medical representatives (53.7%). More than 50% of respondents were unaware of recently banned or approved FDCs.
Conclusion: Most medical practitioners are unaware of FDCs, their rationality, and recently approved and banned FDCs. This limited knowledge leads to suboptimal attitudes and inadequate practices regarding FDCs. A multi-step approach involving all stakeholders, including consumers, medical practitioners, regulatory authorities, industry leaders, and academicians, is necessary to decrease the irrational use of FDCs in India.
87. Clinical Significance of Combined Anti-Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor Assays in Rheumatoid Arthritis Diagnosis
N Anuradha, K. Seeralaboopathy, S. Harinisakthi, N. Shenbhaga Praveen, S. Janani Sakthi, N. Vishwa Chandra Sekar, G Manjula
Abstract
Background: Rheumatoid arthritis (RA) is a Chronic systemic autoimmune disease characterized by inflammatory arthritis especially involving the small joints with irreversible joint damage and extra-articular involvement. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (Anti CCP antibodies) are currently used as biomarkers for diagnostics.in this study, we aimed to investigate the value of combined anti- CCP antibody and RF assays in the clinical diagnosis of patients with RA.
Materials & Methods: A total of 111 new consecutive patients above the age of 16 years who are clinically diagnosed to have Rheumatoid arthritis were tested for the presence of Rheumatoid factor & Anti CCP antibodies.
Result: The sensitivity of RF by Latex agglutination test is 42%, Specificity 88% & Positive Predictive Value (PPV) 90%. The sensitivity of Anti CCP antibody detection by ELISA is 70%, Specificity 93% and PPV 96%. There is a significant increase in the sensitivity of the combined assay when compared to the assays done separately. The specificity & PPV of the combined assay also shows improvement.
Conclusion: The combination assay outperformed any single assay in terms of sensitivity, specificity & PPV.
88. Role of C - reactive protein, Serum Amylase and Apache II Scoring System in Predicting the Severity of Acute Pancreatitis
Abhiram Amudala, Keerthipati Sujan Varma, B. Divya
Abstract
Background: Acute pancreatitis is a catastrophic condition with many complications and poses a great challenge to the treating surgeon. 10-20% of the patients who develop complications will not recover with simple supportive therapy. Hence, an accurate prediction of severity and prognostic monitoring are necessary to anticipate the early and late complications so as to consider aggressive treatment. The present study was aimed at predicting the prognosis in patients with acute pancreatitis by using the Serum Amylase, Serum Lipase, APACHE II scoring system and at determining the utility of these scores in further management.
Methods and Material: 84 patients, who were admitted to the PES Institute of Medical sciences with the clinical and radiological evidence of acute pancreatitis with an elevation in the serum amylase levels, were the subjects of this study.
Results: Among 84 patients, 50 had severe disease and 34 had mild disease based on serum CRP (P<0.05). On the first day of hospitalization Serum Amylase and APACHE II scoring system were analyzed. Serum CRP was taken at 48 hours of admission. The age of incidence was between 31 to 40 years. Males were more commonly affected than females. Alcohol was the main factor in both mild and severe disease related deaths. The percentile of patients for mild and severe pancreatitis for Serum Amylase, APACHE II score and serum CRP includes 83.3%, 45.2%, 40.5% and 16.7%, 54.8%, 59.5%. The Standard Deviation of Serum Amylase, APACHE II score and serum CRP includes 347.1, 3.0, 24.1.The statistical inference of all the three parameters comparing one value with other parameters shows serum CRP has significant value of P<0.05.
Conclusion: Serum CRP plays a significant role in stratifying individuals for early, aggressive treatment in order to reduce morbidity and mortality from Acute Pancreatitis. To define characteristics that allow for the establishment of multifactorial scores or biomarkers to predict acute pancreatitis severity and track disease progression, large population-based multi centre studies must be designed and conducted.
89. Utility of Serum TSH Levels as a Predictor of Malignancy in Thyroid Nodules - A Prospective Study
Abhiram Amudala, Kavya Dasari, Arjun Karthik M.V.
Abstract
Background: Thyroid cancer is one of the most prevalent cancers of the endocrine system. TSH is involved in the regulation of thyroid function such as secretion of thyroid hormones, maintenance of thyroid-specific gene expression and gland growth. Higher TSH levels have also been associated with advanced stage thyroid cancer and it has been suggested that TSH may play a central role in its development and progression. Early detection and treatment are beneficial to prolonged survival. Higher thyroid stimulating hormone (TSH) level in a patient with a thyroid nodule is associated with a greater risk of differentiated thyroid carcinoma. Aim of the study is to evaluate utility of serum TSH levels as a predictor of malignancy in thyroid nodules.
Methodology: Prospective observational study done in 60 cases of Thyroid nodules by Purposive sampling method in patients attended to OPD of Department of General Surgery PES Medical College and Hospital during October 2022 to November 2023.
Results: The results of the study are as follows: Most of the patients were females with an average age of 57.69 ± 11.71 years. The mean age of malignancy was 59 years, with a higher mean age in males (67 years) compared to females (57 years). The majority of malignancy patients presented with a suspicious nodular thyroid (SNT). About 60% of malignancy patients presented with SNT. About 60% of malignancy patients had cervical lymphadenopathy. The mean preoperative TSH value was 1.87 ± 1.23 mU/L. The mean TSH value in malignancy was higher (3.41 ± 0.83mU/L) compared to those with benign disease (1.36 ± 0.86mU/L). The incidence of malignancy increased with higher TSH values.
Conclusion: This study showed that serum TSH estimation can be a useful predictor of malignancy in suspicious thyroid nodules.
90. Comparison of the Effectiveness of Infrared Lamp Therapy versus Sitz Bath in Reducing Pain Perception at Episiotomy Site in Postnatal Mothers with Vaginal Delivery
E. M. Kavitha, S. Bhuvaneswari, Karuna Bhumi Reddy, G. Parthasarathi Reddy
Abstract
Background: Episiotomy, a surgical procedure that involves giving a perineal incision to widen the vaginal opening during childbirth, has been commonly practiced. In managing episiotomy pain and promoting wound healing, two commonly utilized interventions are infrared lamp therapy and sitz bath. This study aims to compare the effectiveness of infrared lamp therapy versus sitz bath in reducing pain perception at episiotomy site in postnatal mothers who have undergone vaginal delivery. By assessing the efficacy of these interventions, healthcare providers can optimize care practices and improve outcomes for women during this critical phase of recovery.
Materials and Methods: This was a randomized control study conducted among 600 Post-natal mothers who delivered by vaginal delivery with mediolateral episiotomy in the Department of Obstetrics and Gynaecology, GMH, Tirupati, Andhra Pradesh, India for a period of 12 months from March 2023 to February 2024.
Results: Majority (72.3%) were aged 21-30 years. Mean age: 23.36±3.57 years. 61.3% were Primipara, 30.7% were Multipara, and 8.0% were Grand multipara. Majority (51.8%) belonged to Low SES. 17.2% held a degree. Majority had normal vaginal deliveries with RMLE (64.8%). 17.7% had forceps delivery with episiotomy, 15.2% had vacuum delivery with episiotomy, 1.3% had preterm vaginal delivery with episiotomy while 1% had twin vaginal delivery (0.2% of this was preterm twin vaginal delivery). Majority experienced moderate pain (66.7%). In the study we observed no significant difference in age between Infra-Red and Sitz Bath groups (p = 0.065), type of delivery (p = 0.520) and significant difference was noted in parity status (p = 0.050), SES (p < 0.001) and education (p < 0.05), pain intensity (p < 0.001) and mean pain score (p < 0.001) between groups.
Conclusion: This suggests that while sitz bath remains a viable option for pain management in the postpartum period, it needs to be supplemented with additional interventions, such as infrared therapy, to optimize wound healing outcomes. Further research exploring the long-term effects and cost-effectiveness of these interventions is warranted to guide evidence-based clinical practice and enhance the quality of care for postnatal mothers.
91. Pregnancy Outcome in Patients with Gestational Diabetes Mellitus by IADPSG (International Association of the Diabetes and Pregnancy Study Group) Criteria in a Tertiary Care Hospital
Lakshmi A., Renuka Ramaiah, Kusuma Naik M. V.
Abstract
Background: Gestational diabetes (GDM) being defined as carbohydrate intolerance of variable severity first diagnosed in pregnancy and is one of the most common metabolic disorders complicating pregnancy. The higher prevalence is due to changes in lifestyle, dietary habits and Indian ethnicity. Aim of the study is to determine the maternal & perinatal outcome in patients diagnosed with GDM by IADPSG criteria.
Patients and Methods: A Prospective study was conducted in the department of Obstetrics and Gynaecology, ESICMC and PGIMSR, Bangalore from January 2020 to June 2021. 206 pregnant women with singleton pregnancy with GDM diagnosed by IADPSG criteria pregnancy were included in the study. The maternal outcome for development of complications like pre-eclampsia, polyhydramnios, preterm labor and post-partum haemorrhage and mode of delivery was determined. Perinatal outcome for birth weight, APGAR score at 5 minutes and NICU admission was measured.
Results: Out of 206 patients included in the study, 64% of patients were multiparous. 62.1% had BMI between 25 – 29.9. Preeclampsia in 24.2%, preterm delivery in 15%. 46.6% delivered vaginally, LSCS in 49% and instrumental delivery in 4.4%. The mean APGAR score at 1 and 5 minute was 7.7 and 8.6 respectively. There was Post-Partum Hemorrhage in 18%, shoulder dystocia in 4.9%. Perinatal complications – IUD – 2.9%, neonatal hyperbilirubinemia – 15.1%, hypoglycemia – 9.7%, and Respiratory Distress Syndrome – 8.7%. NICU admission in 24.8% babies.
Conclusion: GDM is associated with higher morbidity and mortality. This includes maternal complications like preeclampsia, preterm labor, post-partum hemorrhage and shoulder dystocia. Perinatal complications include IUD, macrosomia, neonatal hypoglycemia, hyperbilirubinemia and RDS. By screening, early detection and timely management of GDM, we can achieve the best maternal and perinatal outcome.
92. Comparison of Fentanyl and Butorphanol as Adjuvants to Intrathecal Bupivacaine for Infraumbilical Surgical Procedures
Kruti Bhalodia, Chiragbhai Rathva, Sudha Shah
Abstract
Introduction: Infraumbilical surgeries, including lower abdominal, perineal, and lower limb procedures are frequently performed under regional anesthesia due to its efficacy in providing adequate sensory and motor blockade. Hyperbaric bupivacaine is a commonly used local anesthetic for spinal anesthesia. However, its limitations include hemodynamic fluctuations and insufficient postoperative analgesia. The addition of opioid adjuvants enhances intraoperative analgesia and prolongs postoperative pain relief. Fentanyl, a µ-receptor agonist, is widely used but is associated with side effects such as pruritus, nausea and respiratory depression. Butorphanol, a kappa-agonist and partial µ-antagonist, offers analgesia with fewer opioid-related adverse effects. This study aims to compare the efficacy and safety of intrathecal fentanyl versus butorphanol in combination with bupivacaine for infraumbilical surgeries.
Aims and Objectives: The study aims to evaluate and compare the efficacy of fentanyl and butorphanol as adjuvants to intrathecal bupivacaine by assessing:
Onset and duration of sensory and motor block
Hemodynamic stability.
Postoperative analgesic efficacy using the Visual Analog Scale (VAS).
Incidence of side effects.
Material and Methods: A prospective, randomized study was conducted on 100 patients (ASA Grade I-II, aged 18-75 years) undergoing elective infraumbilical surgeries. Patients were randomized into two groups: Group F (fentanyl 25 mcg with 3 ml 0.5% hyperbaric bupivacaine) and Group B (butorphanol 25 mcg with 3 ml 0.5% hyperbaric bupivacaine). Hemodynamic parameters, sensory and motor blockade characteristics, sedation scores and VAS scores were recorded at regular intervals. Statistical analysis was performed using the unpaired t-test and chi-square test.
Results: Both groups were comparable in demographic characteristics. The onset of sensory block was slower in Group B but had a significantly longer duration. The onset of motor block was similar between groups, but the duration was shorter in Group F. VAS scores were lower in Group B, and the time to first rescue analgesia was significantly prolonged compared to Group F. Hemodynamic parameters remained stable in both groups. Side effects such as hypotension, pruritus and shivering were more common in Group F, whereas sedation scores were higher in Group B.
Conclusion: Both fentanyl and butorphanol are effective as intrathecal adjuvants to bupivacaine for infraumbilical surgeries. However, butorphanol demonstrated superior postoperative analgesia with prolonged sensory and motor blockade, reduced analgesic requirements and fewer side effects, making it a preferable alternative to fentanyl.
93. Bacteriological Profile and Antibiotics Resistance Pattern of Isolates in Neonatal Septicemia in Tertiary Care Centre in North India
RC Guleria, V Kumar, M.Singh, S A Ganju, L R Chandel, R Singh, A Sharma, K. Parmar, A. Singh, N. Saini
Abstract
Background: Neonatal sepsis is a clinical syndrome in infants’ up to 28 days of life manifested by systemic sign of infection and isolation of a bacterial pathogen from the blood stream. A consensus on definition for neonatal sepsis is lacking1 and one of the four leading causes of neonatal mortality and morbidity in India. The aim of present study was to isolate and identify the bacterial isolates which are responsible for neonatal septicemia and determine their antibiotics resistance pattern in a tertiary care centre in North India.
Methods: A total 226 blood samples of septicemic neonate were collected and processed in accordance with standard protocols. Antibiotics susceptibility testing was done by Kirby Bauer disc diffusion method in accordance to Clinical laboratory Standards Institutes (CLSI) 2022 guidelines.
Results: A 21.68% (49 out of 226) case of septic neonate’s blood culture was positive. Staphylococcus aureus was the most common isolates (73.4%) encountered followed by E.coli (16%), Acinetobacter spp (4%), Enterococcus spp (4%) and Klebsiella spp (2%) Gram-positive isolates shows excellent sensitivity to Linazolid and Vancomycin. Gram-Negative organisms E coli is 100% resistant to Ceftazidime ,87.3%, to Ampicillin-Sulbactum and Klebsiella spp are resistant to all drugs.
Conclusion: This study concludes that the isolates organism exhibited higher resistance towards commonly drug used antimicrobials. Health care personal and common population should be aware of the antibiotics resistance to frequently used antibiotics.
94. The Role of Color Doppler in Evaluating Patients with Polycystic Ovarian Syndrome: An Observational Study
Upadhyay T., Yadav S., Chourasia S., Agrawal S., Vishwakarma S.
Abstract
Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women, characterized by ovarian dysfunction, hyperandrogenism, and metabolic disturbances. Advances in ultrasonography, particularly color Doppler, have provided new insights into the vascular alterations associated with PCOS.
Objective: To evaluate vascular changes in the uterine and ovarian arteries using color Doppler ultrasonography in patients with PCOS and establish correlations between clinical, biochemical, and Doppler parameters.
Methods: This observational study included 120 women diagnosed with PCOS based on clinical, biochemical, and ultrasound criteria. Patients underwent transabdominal and transvaginal ultrasonography, with color Doppler assessment of ovarian and uterine artery parameters, including pulsatile index (PI) and resistance index (RI). Correlations between Doppler indices, hormonal levels, and metabolic parameters were analyzed.
Results: The mean age of participants was 24.37 ± 4.08 years, with 65% from urban areas. The most common presenting symptoms were oligomenorrhea (49.2%) and infertility (33.3%). The mean BMI was 27.26 ± 1.77 kg/m², with 89.2% of patients classified as overweight. The mean ovarian volume was significantly increased (Right: 15.79 ± 3.57 ml; Left: 15.71 ± 3.41 ml). The mean ovarian artery PI was 1.02 ± 0.19 and RI was 0.59 ± 0.06, while the mean uterine artery PI and RI were 0.78 ± 0.12 and 2.05 ± 0.69, respectively. Statistically significant correlations were observed between LH, LH/FSH ratio, and uterine artery PI (p<0.05).
Conclusion: Color Doppler ultrasonography demonstrates significant vascular alterations in PCOS, supporting its role as a valuable diagnostic and prognostic tool. These findings may aid in early diagnosis and targeted management strategies for affected women.
95. Articular Veno-Lymphatic Malformation of the Knee Joint: A Rare Cause of Muscle Atrophy
Sachin SK, Vinima VJ, Sana S, Nishat NA, Somya SS, Sachinpuri SAG
Abstract
Venolymphatic malformation (VLM) is a rare vascular anomaly, with fewer than 50 reported cases in the knee joint. We present a case of a 12 year-old Asian girl with no pre-existing illnesses presented with pain over right knee and difficulty in walking over the past few years. The patient had limited mobility and a flexion deformity at her right knee joint and was walking on her toes. The time duration from the onset of symptoms to the diagnosis was approximately of 3 – 3.5 years. She had no history of trauma. Physical examination revealed mild swelling over right knee with marked atrophy of the surrounding muscles at and below the knee joint. Clinical examination revealed fixed flexion deformity of approximately 30 degree. A few conservative management led to reduction of joint swelling for a short duration but did not resolve completely and recurrent exacerbation of swelling was noted. After a conventional radiography, we performed Knee ultrasound followed by 3 Tesla MRI which revealed cluster like venous malformation with associated surrounding muscle atrophy. The diagnosis was further confirmed with histopathologic assessment in this patient. Open surgery was performed which enabled complete excision of the mass and follow up was done.
96. Role of B Mode Ultrasonography and Sonoelastography in Differentiation of Benign and Malignant Cervical Lymph Node
Sachin SK, Vasundhra VS, Vinima VJ, Aniket AC, Prithvi KPP, Tanya TB, Vibhor VD, Salma SK
Abstract
Background: The cervical lymph node pathology spectrum exhibits considerable diversity, encompassing benign reactive changes and malignant transformations. A comprehensive understanding of the etiology, clinical manifestations, and diagnostic nuances is essential for effective patient management. Combined use of ultrasonography and elastography improves diagnostic efficacy in differentiating benign from malignant cervical lymph nodes, thereby helping in treatment planning and reducing unnecessary fine needle aspiration cytology/ biopsy. Our aim of this study is to prospectively differentiate benign and malignant cervical lymph nodes based on B-mode ultrasonography and sonoelastography pattern and correlating them with histological findings.
Material and Methods: Patients underwent ultrasonography (B-mode) followed by elastography. Lymph node morphology on B-mode was assessed based on short axis diameter, short-to-long axis ratio, fatty hilum, echogenicity, and margin. Color Doppler assessment was also done to assess the vascularity pattern. On elastography, lymph nodes were defined based on elastography pattern and strain index and were characterized as benign or malignant using a five-pattern classification to define relative distribution and ratio of soft or hard regions of the LN. The final diagnosis was confirmed using fine-needle aspiration cytology (FNAC), core biopsy, and excisional biopsy according to each patient’s condition, followed by histopathological examination. B mode Ultrasonography and Elastography findings were correlated with FNAC/Histopathological diagnosis for malignant and benign lesions.
Results: The sensitivity and specificity of B-mode USG for diagnosis of malignant lesions was 76.2% and 85.0%. Its positive and negative predictive values were 72.7% and 87.2% respectively. Accuracy of B mode USG was 82%. FNAC/Histopathology diagnosed a total of 21 cases as Malignant while Elastography diagnosed 21 cases as Malignant, 18 true positive, 3 false positive, 3 false negative and 37 true negative. Correspondingly, Elastography had sensitivity, specificity, negative predictive, positive predictive and accuracy values of 85.7%, 92.5%, 85.7%, 92.5% and 90.2% respectively for diagnosis of Malignancy.
Conclusion: Compared with B-mode USG, elastography had a better sensitivity as well as specificity. Elastography can be a useful adjunct to ultrasonography for the accurate diagnosis of cervical lymphadenopathy. Elastography pattern and cut-off strain index of two can effectively differentiate benign from malignant cervical lymph nodes. With such high sensitivity and specificity, elastography had a high diagnostic yield which places it as the diagnostic modality of choice.
97. Study On ECG & Cardiovascular Changes in Pregnant & Non- Pregnant Women
Leena Lucy Surin, Kalyani B. Ghodeswar, Smita Mokal
Abstract
Background: Pregnancy is a physiological condition that can bring changes in ECG pattern and cardiovascular events. It was also found that cardiovascular changes during pregnancy can produce severe complications. It is very important to know the cardiovascular changes & ECG during pregnancy to manage the complications.
Methodology: Total 300 study subjects were enrolled in the study. 150 were non-pregnant as controls and 150 were pregnant as cases. Subjects were investigated for ECG, blood pressure, heart rate, pulse rate, mean systolic blood pressure, mean diastolic blood pressure, and mean arterial pressure. All the readings were recorded.
Results : This was observed that pulse rate , mean systolic blood pressure and mean arterial blood pressure was significantly raised in pregnant women when compared with non-pregnant(p<0.05). In ECG findings short PR interval was significantly more in pregnant women than non- pregnant women (p<0.05).
Conclusion: This can be concluded that in pregnancy both cardiovascular changes as well as changes in ECG pattern can be recorded that can help to manage the complications during pregnancy.
98. Morphological Spectrum of Gallbladder Lesions and their Relationship to Cholelithiasis and Argyrophilic Nucleolar Organizer Regions (AgNORs) in Cholecystectomy Specimens
Bodal Vijay Kumar, Jindal Samidha, Singh Malkiat, Kumar Ashwani
Abstract
Introduction: The most prevalent condition affecting the gallbladder is gallstones. It can lead to acute or chronic inflammation to metaplasias and even cancers. The measurement of argyrophilic nucleolar organizer regions (AgNORs) is a valuable diagnostic tool to determine the malignant potential of gallbladder lesions and is a good sign of cellular proliferation activity.
Aims and Objectives: The study’s main objectives were understanding the morphologic variety of gall bladder lesions and their link to cholelithiasis and AgNOR counts.
Materials and Methods: It was a prospective study done on 100 cholecystectomy samples received from August 2017 to December 2019 for histological evaluation at the department of Pathology. Hematoxylin and eosin staining was done, and slides were examined histopathologically. In 100 cells, the number of AgNOR staining’s, appearing as black dots inside the nucleus, were counted.
Results: In 100 cases included in the study 89% were female and 11% were male, with a female to male ratio of 8.1.1. Out of these 93 (93%) had calculi, including the seven premalignant and three malignant cases. Mean AgNOR counts ranged from 2.57 ± 0.53 in benign cases to 4.53 ± 0.12 in premalignant cases to 8.56 ± 0.57 in malignant cases. A statistically significant increase in AgNOR counts was observed (p 0.001).
Conclusions: Cholecystectomy specimens can reveal a wide range of histological abnormalities, from chronic cholecystitis to cancer. The AgNOR technique is a simple, affordable, and accurate way to determine whether gallbladder lesions have malignant potential.
99. Evaluation of Biochemical and Metabolic Parameters in Patients of Organophosphate and Carbamate Poisoning
Trupti R Jawade
Abstract
Introduction: The wide and free availability of organophosphate and carbamate compound has resulted in gradual increase in accidental and suicidal attempts. Diazinon, Tik 20, Darf, Ragar, Temik, Baygon and several others have been introduced into the market and the new compounds continue to appear periodically. These compounds have different chemical structures, different effects and different metabolic pathways in human body and on consumption produce various acute as well as delayed toxic effects with various metabolic complications. Objective: The present study was undertaken to evaluate the biochemical and metabolic parameters in patients of organophosphate and carbamate compound poisoning.
Method: A Prospective observational study was conducted at Department of Medicine, MGM Medical College and Hospital, Chh. Sambhajinagar, Maharashtra, India. The study included all patients of organophosphate and carbamate poisoning admitted during the study interval.
Results: Out of 45 cases, 62.2% were male and 37.8% cases were females. Ingestion of poison was seen in 97.8% of cases and 2.2% inhalation of poison was observed. Oragnophosphate poisoning was most commonly used i.e. 84.4% cases and Rogar was consumed by 40.0% cases followed by Tick 20 in 22.2% cases. The cause of consumption of poison was suicidal attempt i.e. 91.1% cases followed by accidental in 8.9% cases.
Conclusion: The clinical features found were miosis, sweating, fasciculations, paralytic signs. The acute biochemical and metabolic abnormalities are not rare in organophosphate and carbamate poisoning. Patient with these poisonings should be admitted to an intensive care unit where appropriate biochemical and hematological monitoring facilities are available in order that these serious metabolic and biochemical abnormalities can be treated at an early stage and to rescue the patient from death.
100. Association of Platelet Count with Serological Markers of Dengue Infection and Utility of Immunochromatographic Test for Detection of NS1 Antigen
Siddiqui Heena Kausar, Anupama Wywahare, Manjushree Muley
Abstract
Introduction: Dengue is one of the most serious and viral infection most commonly caused by mosquito bite in man. Dengue is most frequently febrile arthropod borne arboviral disease affecting tropical and sub-tropical regions of the world. Dengue is endemic in India. Objective: The present study had undertaken the utility of immunochromatographic test for detection of NS1 antigen and to know the prevalence of serological markers of dengue infection in a tertiary care hospital.
Method: A Prospective observational study was conducted during October 2015 to September 2017 at Department of Microbiology, MGM Medical College and Hospital, Chh. Sambhajinagar, Maharashtra, India All the samples received in microbiology department from suspected cases of dengue infection attending OPD and IPD of tertiary care hospital during study period had been included.
Results: Out of 243 serum samples 99.17% were positive for either NS1 antigen and/or IgM and or IgG antibodies. 81.48%, 12.34%, 1.23% were positive for only NS1 Ag, IgMAb, & IgGAb, respectively. Out of 241 dengue seropositive patients 41.15% had platelet count <10
5/cmm. ELISA test is more sensitive for detection of NS1 Ag as compared to ICT.
Conclusion: NS1 Ag is an early marker for diagnosis of dengue infection as it can be detected from day one of onset of fever. ICT test detected primary dengue infections and secondary dengue infection on the basis of IgMAb positivity. As secondary dengue infection are associated with higher mortality. ICT test is easy to perform which gives the results within 15-20 minutes without involving any specific laboratory Equipments. For early diagnosis of dengue infection by detection of NS1 Ag gives promising results. Microlisa increases the diagnostic efficiency without the requirement of paired sera.
101. Microbial Etiologies and Current Antimicrobial Susceptibility Patterns of Ventilator Associated Pneumonia in ICU Patients at a Tertiary Care Hospital: Pathogens, Resistance and Clinical Impact
Shazia Mushtaq, Talat Masoodi, Rukhsana Taj, Anjum Farhana
Abstract
Introduction: Ventilator-associated pneumonia (VAP) is defined as pneumonia occurring more than 48 hrs after patients have been intubated and received mechanical ventilation. It is characterized by the presence of a new or progressive infiltrate, signs of systemic infection, changes in sputum characteristics, and detection of a causative agent. VAP pneumonia which contributes to approximately half of all cases of hospital-acquired pneumonia and is the second most common nosocomial infection in the intensive care unit (ICU).
Aims: Primary Aim: To detect the common pathogens causing Ventilator Associated Pneumonia (VAP) and their sensitivity pattern. Secondary Aim: To improve the specificity of the diagnosis of VAP and avoid the consequent unnecessary antibiotic usage and its associated problems.
Results: A total of 230 people suspected of VAP were enrolled in this study. These included 138 60%) males and 92(40%) were females. Endotracheal Aspirate Semi-quantitative culture and blood cultures were done. 40.4% of patients with positive Endotracheal aspirate cultures were considered as VAP cases of which 60.2% were males and 39.8% were females. The most common age group of VAP patients in our study were from 60-74years.The mean age was 65 years. 49.5% of VAP patients were given broad spectrum antibiotics in preceding week. In non-VAP patients only 43% were given broad spectrum antibiotics, showing that prior antibiotic intake is significant risk for development of VAP. 67.7% 0f VAP patients were put on mechanical ventilation for more than 10 days. P value is 0.09 which is significant. Majority of patients in our study (66.6%) had late onset VAP and 34.4% had early onset.
Conclusions: The incidence of ventilator associated pneumonia was around 40 percent among suspected mechanically ventilated patients in intensive care units , being predominantly late ventilator associated pneumonia and caused mainly by multidrug resistant gram negative bacteria, Acinetobacter spp and klebsiella spp. Nearly half the patients who developed ventilator associated pneumonia have taken prior antibiotics. The microbiological profile generated by this study will certainly help in giving guidance for formulating empirical therapy for suspected ventilator associated pneumonia patients. Moreover it will also provide guidance for the development of effective hospital infection control policy and measures which will help in preventing and controlling ventilator associated pneumonia.
102. Estimation of Serum Vitamin D Level and Its Relation to Glycemic Control in Newly Diagnosed Type 2 Diabetes Mellitus
Nayanjyoti Bez, Kalpana Chetia, Bharati Devi, Harish R, Uttam Kumar Nath
Abstract
Background: Vitamin D deficiency is associated with insulin resistance and type 2 diabetes through several mechanisms. Vitamin D also influences insulin receptor expression, enhancing glucose transport responsiveness.
Aims & Objectives: To estimate serum vitamin D level and its relation to glycemic control in newly diagnosed type 2 diabetes mellitus, as assessed by HbA1c percentage with the objectives to estimate the serum vitamin D level in newly diagnosed type 2 diabetes mellitus patients and to find out relationship between serum vitamin D level and glycemic control in newly diagnosed type 2 diabetes mellitus.
Materials and Method: This hospital based cross sectional study was conducted in the Department of Medicine, Jorhat Medical College and Hospital, Jorhat, Assam. Total of 70 newly diagnosed type 2 diabetes patients were enrolled in this study.
Results: Mean age of patients was 53.4 years. 40(57.1%) were males & 30(42.9%) were females. Mean HbA1c of newly diagnosed diabetic patients was 9.31%. 52.9% (n=37) had HbA1c in range of 6.5 to 9%; 31.4% (n=22) had HbA1c in range of ≥ 9 to12%; 15.7% (n=11) had HbA1c in range of ≥12%. Total of 29(41.4%) patients were found to be having insufficient levels of Vit D and 16(22.9%) other patients were deficient of Vit D. 25(35.7%) patients had sufficient levels of Vit D. Individuals with Vit D levels <20ng/ml had significantly higher HbA1c levels (11.55%) with regard to those who have levels of Vit D in 20-30ng/ml category (9.26%) & above 30ng/ml (7.94%).
Conclusion: From this study it can be concluded that most of the newly diagnosed type 2 diabetes patients were found to be having either deficient or insufficient levels of circulating vitamin D level. It is also found that with increasing level of HbA1c, there is increased frequency of serum vitamin D deficiency.
103. Prevalence of Micronutrient Deficiency During Pregnancy in Rural Population and Feto-Maternal Outcomes: A Community-Based Study from South Bihar
Rimjhim Kumari, Kumari Veena Sinha
Abstract
Background: In pregnancy, deficiency of micronutrients like vitamins and minerals has been documented in previous studies. The possible deleterious effects of the deficiency on fetal outcomes and feto-maternal health are shown to be associated in some studies. However, data are scarce from Eastern India.
Objective: To determine the health institute-based point prevalence of selected micronutrients in pregnant mothers and their association with adverse fetal and maternal outcomes.
Methodology: In this community-based prospective observational study, complete blood count, vitamin B12, vitamin D, folic acid, iron profile, zinc and calcium are measured from pregnant mothers who attended 4 primary health centers in Jamuhar, Sasaram (Rohtas district) of Bihar during February 2024 to January 2025. ELISA and RIA were used to estimate serum ferritin and folate with minimum cut-off 15 and 3 ng/mL respectively. By food frequency questionnaire, pattern of food consumption was assessed. ECLIA was used to estimate vitamins B12 and D with minimum cut-off 197 pg/mL and 50 mmol/L. All mothers were followed up (physically and/or telephonically) to observe fetal and maternal outcomes till at least 1 month after delivery.
Results: Out of 251 pregnant women, 156 (62%) had Vitamin B12 deficiency, 148 (59%) had Vit D deficiency; 126 mothers (50%) had Zinc deficiency and 73 (29%) had Ferritin deficiency. 112 participants (45%) had anaemia. Most mothers (54%) were in the second trimester. 123 mothers (49%) were suffering from multiple micronutrient deficiency. Significantly higher incidence of adverse fetal and maternal outcomes was associated with multiple micronutrient deficiency (Odds Ratio 2.656, 95% CI 1.246 – 5.657; P = 0.011).
Conclusion: Pregnant women were suffering from deficiency of multiple micronutrients of which Vitamin B12 and Vitamin D deficiency were high. The incidence of adverse fetal and maternal outcomes was significantly high in mothers with multiple micronutrient deficiency.
104. Study of Serum Hepcidin, Folic Acid, Vitamin B12 and Iron in Anemic Pregnant Women in Indore Region
Alok Kumar Maurya, Jaya Jain, Ashutosh Jain
Abstract
Background: Gestation, or pregnancy, is a critical period characterized by various physiological changes, including the development of the embryo into a fetus across three trimesters. Nutritional deficiencies, particularly iron, folic acid, and vitamin B12, significantly impact maternal and fetal health, leading to conditions such as anemia. Anemia, especially iron deficiency anemia (IDA), is prevalent in developing regions like Madhya Pradesh, India, where approximately 60% of pregnant women are affected, posing risks of premature birth and low birth weight. Understanding the roles of these nutrients and the regulatory peptide hepcidin is essential for improving maternal and fetal health outcomes.
Aim & Objective: To study serum hepcidin, vitamin B12, Folic acid and Iron in anemic pregnant women in Indore region. Compare all these parameters between cases and controls.
Materials and Method: Total 300 subjects were studied which were divided into two groups of 150 of anemic pregnant women as cases and 150 non-anemic pregnant women as controls. Healthy controls after defining proper inclusion and exclusion criteria. Hepcidin was estimated by ELISA, vitamin B12 & Folic acid was estimated by C.L.I.A. while Iron was estimated by Ferrozine method without deproteinization.
Results: Anemic pregnant women exhibited significantly lower levels of serum Hepcidin, serum folic acid, serum Vitamin B12 and serum Iron compared to non-anemic pregnant women as controls. The differences were statistically significant (p < 0.05), indicating the need for monitoring and nutritional support for anemic pregnant women.
Conclusion: This study highlights the significant nutritional deficiencies in anemic pregnant women as compared to non-anemic pregnant women. Regular screening and targeted interventions, including dietary counseling and supplementation, are essential to prevent anemia and promote maternal-fetal health during pregnancy.
105. Clinicopathological Correlation of Endometrial Lesions in Abnormal Uterine Bleeding at a Tertiary Care Hospital
Bindu PJ, Madhavi BV, Vasundara G, Monica M
Abstract
Background: Abnormal uterine bleeding is a problematic condition affecting women of all ages, with Indian women showing a high prevalence rate. Endometrial pathology is a major cause of AUB, which the pathologist can discern via light microscopy.
Objectives: To study the histopathological spectrum of endometrium in cases of abnormal uterine bleeding in correlation with clinical features such as age, parity, and pattern of menstrual bleeding in a tertiary care hospital.
Materials and Methods: This is a descriptive cross-sectional study conducted in the Department of Pathology at GITAM Institute of Medical Sciences and Research, Visakhapatnam for one and a half years, from September 2022 to March 2024. We have included 319 patients who underwent dilatation and curettage, hysterectomy, or both, in the study.
Results: Heavy menstrual bleeding was the most common symptom, with proliferative and secretory phases of the endometrium being the most common endometrial morphology. We encountered cases of endometrial polyps, endometrial hyperplasia and endometrial carcinoma among others. Leiomyoma was the most common finding in patients who underwent hysterectomy, with some women showing no structural cause.
Conclusion: Evaluating the endometrium is an essential diagnostic tool for assessing AUB, which can be influenced by many factors. Women should be educated about recognizing the changes in menstrual bleeding patterns for safer outcomes.
106. A Study on the Causes and Clinical Characteristics of Chronic Liver Disease in a Tertiary Care Center
Meet Kiritbhai Adroja, Shreya Kantilal Koradia, Milan Mori, Raj Vinodbhai Dhokiya
Abstract
Introduction: Chronic liver disease (CLD) is a major global health concern, leading to progressive liver dysfunction, cirrhosis, and increased morbidity and mortality. The etiological factors of CLD vary across populations, with viral hepatitis, alcohol-related liver disease, and non-alcoholic fatty liver disease (NAFLD) being the most common causes.
Materials and Methods: This prospective observational study was conducted at a tertiary care center in Western Gujarat over one year. Patients diagnosed with CLD based on clinical, biochemical, radiological, and histopathological findings were included, while those with acute liver disease or incomplete records were excluded. Data collection involved demographic details, medical history, lifestyle factors, laboratory investigations, and imaging studies. The severity of CLD was assessed using standard scoring systems. Statistical analysis was performed to determine the prevalence of different etiological factors and their association with clinical presentations.
Results: Our study on chronic liver disease (CLD) revealed that the majority of patients were aged 51-60 years (29.2%), with a male predominance (70.0%). Laborers (41.7%) and individuals from lower-income groups (60.0%) were most affected. The most common causes of CLD were Hepatitis B (33.3%), alcoholic liver disease (30.0%), and NAFLD (18.3%), while Hepatitis C, autoimmune hepatitis, and metabolic disorders contributed to a smaller proportion of cases. Fatigue (70.8%), jaundice (58.3%), and ascites (54.2%) were the most common presenting symptoms. Ascites (56.7%), portal hypertension (45.8%), hepatic encephalopathy (33.3%), and variceal bleeding (25.0%) were the predominant complications, reflecting the advanced disease stage at presentation. Laboratory findings showed elevated bilirubin, AST, ALT, and alkaline phosphatase, alongside low serum albumin and platelet counts, indicating significant liver dysfunction.
Conclusion: Chronic liver disease remains a significant health concern, with Hepatitis B, alcohol-related liver disease, and NAFLD being the leading causes. Early diagnosis and targeted interventions are essential to reduce complications and improve patient outcomes.
107. Retrospective Analysis of the Trends and Patterns of Anti-Microbial Resistance in Various Patient Populations
Sanjay Kumar, Kaushal Kumar Mishra, Satyendra Kumar Pathak
Abstract
Background: AMR is a present day universal healthcare challenge especially in the tertiary health care centres in which MDR organisms are evident. In pursuing the aim of this cross-sectional study, the following objectives were set: To assess the current trends of AMR in the selected bacterial pathogens in a tertiary care hospital and To determine the practicing clinicians knowledge, attitude [KA] towards AMR.
Methods: A cross-sectional study was carried out on bacterial isolates derived from clinical samples from January 2020- December 2023 in a tertiary health facility. The data of resistance patterns were obtained from the microbial report forms and included the prevalent hospital-associated pathogens, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. Trends in the resistance profiles to antibiotics under study were determined using beta-lactams, fluoroquinolones, carbapenems and aminoglycosides.
Results: In the present investigation, a total of 2,346 bacterial isolates were used in the study. E. coli had resistance rates to fluoroquinolones 45.3%, to third generation cephalosporins 30.1%, and to carbapenems 18.5%. K. pneumoniae had resistance rate of 41.8% to beta-lactams and 28.9% to carbapenems. Aminoglycoside resistance of P. aeruginosa was 35.6% and methicillin resistance of S. aureus was 22.3%. Of interest, resistance to more than one antibiotic class was identified in 12.4% of the isolates, and extensive drug resistance in 3.5% of the isolates.
Discussion: The results highlight concerning trends in AMR among hospital-associated pathogens. The high resistance rates to essential antibiotics, particularly carbapenems and fluoroquinolones, pose significant challenges to treatment options. The increasing prevalence of multidrug-resistant organisms necessitates enhanced antibiotic stewardship programs (ASPs) and infection control strategies. Diagnostic stewardship should be prioritized to ensure timely and accurate identification of pathogens, minimizing unnecessary antibiotic use.
Conclusion: The findings reveal some worrying tendencies in the development of AMR in hospital-associated pathogens. The overall resistance rates to these core antibiotics, carbapenems and fluoroquinolones are high and limit the treatment options. Multidrug-resistant organisms are becoming more common, which means that ASPs and infection control measures must be improved. Diagnostic stewardship should be given a priority in order to identify pathogens on time and reduce the prescription of unnecessary antibiotics.
108. Retrospective Analysis of the Incidence and Risk Factors of Drug – Drug Interactions in Hospitalized Patients
Sanjay Kumar, Ashoka Kumar Chowdhury, Satyendra Kumar Pathak
Abstract
Background: DDIs are a major issue in hospitalized patients as they result in ADEs, longer hospitalization, and higher costs. DDIs are more likely to occur in patients with multiple co morbidities and on multiple medications. The knowledge of the risk factors for DDIs is important in enhancing patient safety and enhancing the desired therapeutic effects in the hospital.
Objective: The purpose of this study is to identify the incidence of DDIs in the patients admitted in the hospital and to understand the factors that put the patients at risk such as polypharmacy, elderly patients and patients admitted in ICU. The purpose is to recognize these factors in order to design preventive measures for managing DDIs.
Methods: A retrospective cohort study was carried out and data from patients admitted in the hospital were used. Polypharmacy defined as the use of five or more medications, age greater than or equal to 65 years, and admission to the ICU were evaluated with regard to the presence of DDIs. The ORs and 95% CIs were used to assess the magnitude of these risk factors in relation to the development of DDIs. Significance of the results was analyzed using p-values.
Results: The study found that polypharmacy increased the risk of DDIs by 3.5 fold (95% CI 1.8-6.9, p = 0.001). Age above 65 years was also a significant risk factor, showing an odds ratio of 2.8 (95% CI: 1.4-5.6, p = 0.005). ICU admission was found to be the strongest risk factor for DDIs, with an odds ratio of 4.2 (95% CI: 2.1-8.4, p = 0.0001). These results show the importance of these factors in the development of DDIs in hospitalized patients.
Conclusion: The study underscores the significant burden of DDIs in hospitalized patients, particularly among those with polypharmacy, advanced age, and ICU admission. Addressing these risk factors through vigilant monitoring, tailored interventions, and collaborative care models can help mitigate the adverse effects of DDIs, enhance patient safety, and improve clinical outcomes. Healthcare providers should be aware of these risk factors to optimize drug regimens and reduce the likelihood of harmful drug interactions.
109. Observing Demographic Details and Procedures Undergone by Patients Coming in Emergency with Perforation Peritonitis in Tertiary Care Center of Central India: An Observational Prospect
Amey Jain, Manoj Paraste, Pragyey Nawlakhe, Sandeep Jain, Deepesh Gupta, Devendra Chaudhary, Arvind Rai
Abstract
Perforation peritonitis is amongst the most frequently encountered surgical emergency in general surgery. Incidence of perforation of hollow viscus, the site of perforation, and age at which it occurs are all variable in the developing world, and the trends are ever changing. The spectrum of etiologies leading to peritonitis as a result of perforation differs in the developing world, from that in the developed parts of the world.
The present study was conducted as a prospective observational study on patients who underwent Emergency surgery for Perforation peritonitis in the Department of General Surgery, at a tertiary care center of Madhya Pradesh during the period 2022 to 2024. This is a hospital based comparative study.
The sample size of this study was 100. Majority of these patients were Males (84%) while the remaining were Females (16%). 61% patients (61 out of 100 patients enrolled) were found to have no co-morbidities. While 39% patients had different kinds pre-existing co-morbid conditions showing variable degree of overlap i.e. a single patient showing multiple co-morbidities. In our study, it was observed that majority (56%) of the patients were found to have Gastric perforation who underwent either Grahams’s patch repair (36%) or Modified Graham’s patch repair (20%) patients were managed with primary repair of the perforation with or without stoma formation.
In India perforation peritonitis presents as an entirely different spectrum as compared to the western countries. An early diagnosis with adequate pre- operative resuscitation focusing on correction of fluid and electrolyte imbalance followed by an early surgical intervention to provide source control under the cover of appropriate antimicrobials/antibiotics is key to achieve good outcome with minimal morbidity and mortality. Hence this study could be a stepping stone towards easier diagnosis and management of emergency abdominal surgeries. Such studies should be performed on a larger scale to calibrate and demarcate the need of time for repairing perforated abdomen which is beyond scope and limitations of present study.
110. A Study of Medical and Surgical Management of Thyroid Swelling
Arundhati R. Patel, Vidhitkumar D. Patel, Happy A. Patel, Deepti R. Tulsiyani
Abstract
Background: Thyroid disorders are one of the most prevalent endocrine conditions worldwide, with a significant burden in India. Thyroid swellings require a systematic approach for diagnosis and management, including medical, minimally invasive, and surgical interventions.
Objectives: This study aimed to determine the incidence, clinical characteristics, and outcomes of thyroid swellings, assess the correlation between fine-needle aspiration cytology (FNAC) and histopathological examination (HPE), and evaluate different treatment modalities.
Methods: A prospective observational study was conducted at a tertiary care center from May 2022 to February 2024. A total of 100 patients presenting with thyroid swelling were evaluated through clinical examination, ultrasonography (USG), FNAC, and thyroid function tests (TFTs). Patients were managed based on their diagnosis, either conservatively, with medical therapy, microwave ablation, or surgery. Histopathological examination was performed on excised specimens to confirm the diagnosis.
Results: The most commonly affected age group was 18–39 years (59%), with a female-to-male ratio of 8:1. 82% were euthyroid, 15% hypothyroid, and 3% hyperthyroid. FNAC had a diagnostic accuracy of 97.5%. Hemithyroidectomy was performed in 78.75% of cases, while microwave ablation had a 66.67% success rate in reducing nodule size. Postoperative hypocalcemia (8.75%) was the most common complication.
Conclusion: Thyroid swellings are predominantly benign and more common in females. FNAC is a highly accurate diagnostic tool, while hemithyroidectomy remains the preferred surgical approach. Early diagnosis and appropriate treatment improve patient outcomes.
111. Baseline C-Reactive Protein as a Predictor of Response to Treatment in Depression
Bushra Zahoor, Manoj Kumar, Om Prakash, Dimple Gupta, Rajeev Thakur
Abstract
Objective: Major depressive disorder has been linked with inflammatory processes, but it is unclear whether individual differences in levels of inflammatory biomarkers could help in predicting the response to treatment. The authors tested the hypothesis that C-reactive protein (CRP), a commonly available marker of systemic inflammation, predicts differential response to treatment in depression.
Method: The hypothesis was tested in patients admitted at a tertiary care centre. CRP was measured with a high-sensitivity method in serum samples from 50 adult men and women with major depressive disorder randomly allocated to this study. The primary outcome measure was the score on the Becks Depression Inventory, Hamilton depression rating scale along with the Clinical Global Impression scale administered on day 1, day 14, and day 28.
Results: CRP level at baseline differentially predicted treatment outcome within the two groups. For patients who were tested CRP Negative(level ≤6mg/l), an improvement on the HAM-D and BDI score was greater as compared to the CRP Positive group(level ≥6mg/l). This study showed that the response rate is affected by a high level of baseline inflammation measured by the serum C- Reactive protein levels.
Conclusions: An easily accessible peripheral blood biomarker may contribute to improvement in outcomes of major depressive disorder.
112. Chronic DRUJ Instability Management using Modified Adam Berger Technique: A Prospective Study
Muthukumar Balaji, Sabari Vaasan L, Suriya Prasanna Raja, Ashlee Isaac, Thirumalai G, Vamsi Krishna Maddineni
Abstract
The primary contributors to the stability of DRUJ are the dorsal and palmar radioulnar ligaments, while the bony structure only provides around 20% of the overall stability. Chronic DRUJ instability often results from untreated or improperly treated injuries, such as fractures or triangular fibrocartilage complex (TFCC) ligament insufficiency. If DRUJ instability is not properly managed, it can disrupt the normal kinematics of the wrist and forearm, leading to discomfort, weakness, and degenerative osteoarthritis. DRUJ instability is diagnosed when there is excessive ulnar translation in relation to the radius compared to the unaffected wrist on the opposite side. If left untreated, these issues can progressively worsen, leading to further degeneration of the TFCC, joint arthritis, and functional impairments of the wrist and forearm.
113. Comparative Analysis of the Efficacy of two Different Doses of Dexmedetomidine (0.5mcg/kg vs 1mcg/kg) when Added as an Adjunct to Bupivacaine 0.5% in Supraclavicular Brachial Plexus Block
Anand G. Valu, Puneeth H. Pujar, Bhargavi
Abstract
Brachial plexus block is a reliable method to provide analgesia and anaesthesia to upper limb surgeries. Supra clavicular brachial plexus block is one of the most common types of brachial plexus blocks performed for upper limb surgeries. Adjuncts such as buperinorphine, fentanyl, tramadol, neostigmine, dexamethasone, dexmedetomidine have been used with local anaesthetic for supraclavicular block.
114. A Study on Etiological Evaluation of Pancytopenia in Elderly: Need to Shift Gears
Anuja Dasgupta, Uma K., Nanditha H.S., Shilpa S. Biradar
Abstract
Introduction: Pancytopenia is not a disease entity but a triad of findings that may result from several disease processes. The differential diagnosis of pancytopenia in elderly can be exhaustive ranging from nutritional anaemia to malignancy. A detailed history with physical examination and a review of the blood film remains fundamental to the diagnosis of pancytopenia.
Aim: To study the aetiological profile of pancytopenia in the elderly.
Materials and Methods: 36 patients who were more than 60 years of age were clinically evaluated, with complete blood count, peripheral smears, and bone morrow aspiration-biopsy whenever possible, in Akash Hospital, Devanahalli, Bengaluru from May 2023 to October 2024. Patients with haemoglobin <10g/dL, total leukocyte count <4000/µL, and platelet count <1 lakh/µL were included in the study; while those diagnosed with leukaemia on chemotherapy, abnormal bleeding parameters, or had received blood transfusion were excluded.
Results: Of the 36 patients, majority of the cases were seen in the age group of 60-70 years of age, with predominance of males. Most common cause of pancytopenia in this study was Megaloblastic anaemia (22.2%), followed by Alcoholic liver disease (19.4%) and Myelodysplastic syndrome (13.9%). 3 cases of liver cirrhosis following non-alcoholic fatty liver disease were also noted.
Conclusion: Pancytopenia in elderly indicates significant underlying pathology that can be attributed to the nutritional, personal habits and infective causes. In this study, the most common aetiology was megaloblastic anaemia. An increase in incidence of liver disease is probably due to increasing trend of alcoholism in our society. Identification of cause can help the clinician in initiation of appropriate therapy.
115. Study of Coagulopathy in Chronic Liver Disease: A Prospective Observational Study
Kumpati Prudvi Raju, Raju Prabhakar Talawar, Kiran Kumar BN
Abstract
Background: Chronic liver disease (CLD) is associated with complex hemostatic alterations that can lead to both bleeding and thrombotic complications. This study aimed to investigate coagulopathy in CLD patients and understand its clinical implications.
Methods: This prospective observational study enrolled 43 adult patients with CLD of varying severity. Coagulation parameters (PT, INR, aPTT, platelet count) were assessed at baseline and during follow-up. Patients were monitored for bleeding and thrombotic events. Correlations between coagulation parameters and disease severity (Child-Pugh and MELD scores) were analyzed, and predictors of clinical events were identified using multivariate regression.
Results: The study population (mean age 54.3 ± 11.7 years, 74.4% male) comprised 34.9% Child-Pugh A, 41.9% Child-Pugh B, and 23.2% Child-Pugh C patients. Coagulation parameters showed significant deterioration with increasing Child-Pugh class (p<0.001 for all parameters) and strong correlations with disease severity scores (r=0.756 for INR and Child-Pugh score, p<0.001). During the study period, 32.6% of patients experienced bleeding events and 14.0% developed thrombotic complications. Patients with bleeding events had significantly worse baseline coagulation parameters compared to non-bleeders (INR: 2.1 ± 0.6 vs. 1.5 ± 0.4, p=0.001; platelet count: 93.4 ± 32.6 vs. 134.7 ± 45.8 × 10³/µL, p=0.004). Multivariate analysis identified INR > 1.8 (adjusted OR=4.28, p=0.012), platelet count < 100 × 10³/µL (adjusted OR=3.74, p=0.020), and Child-Pugh Class C (adjusted OR=3.95, p=0.017) as independent predictors of bleeding. Dynamic worsening of coagulation parameters was significantly associated with bleeding risk in Cox regression analysis.
Conclusion: Coagulopathy in CLD correlates significantly with disease severity and has important clinical implications. Conventional coagulation tests retain value in bleeding risk stratification, while their limitations in predicting thrombotic complications highlight the complex “rebalanced hemostasis” in CLD. Regular monitoring of coagulation parameters and individualized management approaches are essential in these patients.
116. Rare Presentation of Right Second Metacarpophalangeal Joint Dislocation (Kaplan Dislocation): A Case Report
Amol Dilip Havale, Rajesh Kishanrao Ambulgekar
Abstract
Metacarpophalangeal dislocations are rare they are subdivided as simple and complex dislocations, complex dislocations are also called as Kaplan Dislocation.
While simple volar dislocations can often be reduced through closed maneuvers, complex dislocations are complete and require surgical intervention as they are irreducible through closed maneuvers.
We present a case of a complex 2nd MCP joint dislocation in a 28 year -old female patient who sustained a hyperextension injury to his index finger. The patient underwent open reduction surgery using a volar approach due to the buttonholing of the phalangeal head through the volar plate and blockage between the flexor tendons and lumbrical muscle. Following the procedure, the joint was immobilized in a palmar slab at 30°-40° flexion for 2-3 weeks before being allowed unrestricted mobilization. At the 6-week follow-up, the patient reported being pain-free and had nearly full range of motion in the index finger MCP joint.
117. Microbiological Surveillance of Operation Theatres of a Tertiary Care Hospital in Bihar
Shreya, Sanjay Kumar, Satyendu Sagar, Rajesh Kumar, Wasim Ahmad, Babita, Chandan Kumar, Sarita Kumari, Nushrat Jahan, Atul Anand
Abstract
Background: Microbial contamination of air and environment in operation theatres (OTs) has continued to increase the prevalence of surgical site and hospital-associated infections. Control of these infections in operation theatres is of utmost importance as it can increase patient’s morbidity and mortality.
Aims and Objectives: Aim of the present study was to identify bacterial colonization of surfaces and to determine the microbial contamination of air by estimating the bacterial colony forming unit (CFU) rate in the OT’s of a tertiary care hospital.
Material and Method: This was the tertiary care hospital based retrospective cross-sectional study done for a period of 18 months. Data was collected from routine microbiological surveillance of OT’s done in between February 2023 to July 2024. Two sampling procedures were considered in this study. For air quality surveillance, settle plate method whereas for surface sampling, soaked swabs from different sites in peptone water were included. Collected samples were transported to Microbiology Laboratory of the institution in sterile condition and careful observation was done of bacterial species, which were isolated and further identified by conventional methods.
Results: A total of 463 samples were collected from different surfaces of various OT’s. Out of these 43 samples showed bacterial growth. The predominant species isolated was coagulase-negative Staphylococcus 31/43, Klebsiella species 8/43, E.coli 2/43, Staphylococcus aureus 1/43 & Pseudomonas aeruginosa 1/43. OT’s air samples showed highest colony forming unit (cfu) rate in Labor room (123cfu/m
3) and least cfu rate in Radiotherapy (37cfu/m
3).
Conclusion: OTs of our hospital showed highest bacterial contamination in Labor room where the patient load was high and among all the surfaces, OT tables and floor were mostly contaminated with microorganisms.
118. Retinopathy of Prematurity: Incidence, Risk Factors and Outcome
Manjula Bussa, Bhavani V Mallampalli, Divya Reddy Kailasam, Chandini Bandaru
Abstract
Aim and objective: To study the incidence, risk factors and outcome of ROP in high risk infants.
Material and Methods: All neonates of birth weight < 1500 g and/or with a gestation < 34 weeks admitted to NICU were routinely screened for ROP. Preterm Infants who underwent screening for ROP and infants who are diagnosed as having retinopathy are taken into the study. Data is analysed using MS Excel software &SPSS software (version 16).
Results: Incidence of ROP is 28.5%, Gestational age and birth weight are the important significant risk factors for ROP in the study. Gestational age and birth weight are reciprocally related to the incidence of ROP. Oxygen exposure, neonatal sepsis, thrombocytopenia, surfactant, and mechanical ventilation are the other significant risk factors in the study. Laser photocoagulation was found to be effective in the treatment of ROP in the present study.
Conclusion: Early diagnosis and prompt treatment of antenatal and natal risk factors prevent the incidence of ROP. Infants with risk factors should be screened regularly for ROP development. Usage of recent technology like retinal imaging with RETCAM can aid in the early diagnosis and prompt referral.
119. Association of Vitamin D Levels and Mortality in Sepsis Patients: A Single-Center Study from Western Uttar Pradesh
Deepak Kumar Singh, Aparna Singh, Praveen Kumar Naik, Divya Singh
Abstract
Background: Sepsis is the leading cause of death in Pediatrics Intensive Care Unit (PICU). Vitamin D deficiency is associated with an increased risk and progression of the disease, especially sepsis. A low level of serum Vitamin D when patients admitted in Pediatric Intensive Care Unit (PICU) is at higher risk of death. Therefore, the study was conducted to evaluate the impact of Vitamin D levels in treatment outcome in patients admitted in Paediatrics, Intensive care Unit (PICU).
Material and Methods: This observational prospective cross sectional study carried out in the paediatric intensive care unit of U.P.U.M.S. Saifai, Etawah on all patients admitted in PICU more than 1 year to < 14 years age. Vitamin D was measured by ELISA method. PRISM III scoring on admission, at 24 hour and at 48 hour were recorded. Disease Severity and outcome was evaluated by correlating the vitamin D level with the change in pattern of PRISM III value.
Results: This study was carried out on 358 patients with sepsis whose outcome was known and admitted to the PICU, Saifai, and Etawah. Out of them 79 cases were expired. Mean Vitamin D levels were significantly higher in those who were discharged (29.08±20.85 nmol/L) as compared to those who expired (22.35±15.94nmol/L) (p = 0.0083). Mean values of PRISM score in cases of sufficient vitamin D level at 0 hr, 24 hr and 48 hrs are 42.18±9.99, 38.20±10.94 and 34.47±13.13 respectively, while these values were 45.24±8.88, 44.53±10.94, 43.71±14.89 at 0 hr, 24 hr and 48 hr.
Conclusion: The prevalence of vitamin D deficiency in sepsis patients in PICU was estimated as 61.6%. A significant and indirect correlation was found between the serum level of vitamin D and mortality. 25(OH)D deficiency is prevalent in critically ill children at PICU admission and seems to be associated with higher PRISM-III score.
120. Antibiotic Resistance Patterns and Identification of Staphylococcus aureus in Clinical Specimens
Versha Rajput, Kailash Jatav, Naveen Kumar Patidar
Abstract
Antimicrobial resistance is a significant global issue causing millions of deaths, long-term impairments, and increased medical expenditures. The investigation reveals a direct relationship between the widespread use of antimicrobials in human and veterinary medicine and the proliferation of resistant bacteria strains. Methicillin-resistant Staphylococcus aureus (MRSA) is an enormous pathogen that causes a wide range of infections, from minor skin infections to life-threatening conditions like sepsis, pneumonia, and endocarditis. In this study total 700 samples were included, out of which 358 samples were found positive for Staph aureus, after that antibiotic sensitivity testing was done for 358 Staph aureus isolates. Accurate treatment will help to improve the better patient’s outcome and reduces the morbidity rate. An antibiotic policy and screening of susceptibility patterns of MRSA may also help in reduces the prevalence rate of MRSA and antibiotic resistance.
121. A Study on Clinical Correlation Between Rapid Urease Test and Histopathology in H. pylori Induced Gastritis
Shweta Joshi, Vivek Khare, Krishna Chandra Pant
Abstract
Objectives: The present study was to evaluate the clinical correlation between rapid urease test and histopathology in
H. pylori induced gastritis.
Methods: 50 patients participated and underwent OGD scopy guided gastric mucosal sampling, 5 gastric mucosal bits were taken from all quadrants of stomach. Among those one bit was used for RUT test and rest were fixed in formalin in paraffin embedded blocks and sent to lab for histopathology for H&E staining and examined for
H. Pylori in mucosa and gastric crypts. The enzyme Urease in H.pylori react with urea of test bed producing ammonia reacts with the phenol red indicator in the test changing the colour to pink a positive rut dry test indicates the load of bacteria of around 10
5 H. pylori in the specimen. Based on laboratory and histopathology reports, the true positives, true negative, and sensitivity and specificities of RUT test and Histopathology were calculated and compared.
Results: Out of the 50 cases 92% of patients belonged to lower socio economic status. P was less than 0.000 and it was statistically significant. H&E detected
H. pylori in 36 cases and majority of them had grade 1 gastritis(34%). RUT test showing 33 cases positive among 50 samples, RUT was negative in 17 samples. H&E staining detected H.pylori in 36 samples out of 50 and 14 samples were free of H.pylori. The true positives of RUT were 33 and true negatives were 14.
Conclusions: Accuracy of Histopathology (H&E) is better but it is the cost effective and the time consuming. RUT should be used as an informal assessment of the accuracy of the pathology laboratory and discrepancies between the RUT and histology especially a positive RUT and negative histology should lead to prompt review of the histopathology. The positive tests, should be correlated with endoscopy findings and histological assessment of gastric mucosa. Therefore, to maintain high sensitivity and specificity and accurately diagnose the pathogen, it is important to use at least two diagnostic tests depending on the clinical situation.
122. Functional and Radiological Outcomes of Neck of Femur Fracture Treated with Cannulated Cancellous Screws
Salmanul Faris A, Khayas Omer Kunheen, Arun Prakas PJ, Sadiquali PP, Nithin Karun, Manoj Kumar CV
Abstract
Background & Objectives: This study was conducted to assess the functional and radiological outcomes of neck of femur fracture treated with cannulated cancellous screws. Study also assessed the associations of functional outcome, fracture union rates and complications.
Materials & Methods: This analytical cross-sectional study was conducted on 80 patients with neck of femur fracture who had undergone internal fixation with 3 cannulated cancellous screws. AP and lateral X-rays of the hip were taken for radiological evaluation. The functional status of the patients was assessed by Harris hip score. The data was collected and analysed statistically to draw conclusions.
Results: The study included 80 patients with femoral neck fractures, comprising 58.8% males and 41.3% females, aged 18 to over 50 years. Fracture types were predominantly Garden type II (42.4%) and type III (32.5%), with fewer cases of type I (13.8%) and type IV (11.3%). Outcomes were excellent in 42.4% of patients, good in 33.8%, fair in 18.8%, and poor in 5%. Harris Hip Scores were highest for type I fractures (93.45), followed by type II (86.76), type III (83.31), and type IV (81.44).
Conclusion: Garden’s classification system provided prognostic insights, showing that non-displaced or minimally displaced fractures (Types I and II) generally had better outcomes, lower complication rates, and higher Harris Hip Scores (HHS). Conversely, displaced fractures (Types III and IV) had higher complication rates, including non-union and avascular necrosis, indicating their increased severity and treatment challenges. Overall, the study confirms that early, appropriate surgical intervention with CC screws is effective, especially for less severe femoral neck fractures.