Quinazolinones have various biological activities such as anticancer, antibacterial, antidiabetic, anticonvulsant, antihistaminic, antiinflammatory, antifungal, anthelmintics and antiviral activities. In this research some of compounds 2,3-disubtituted quinazolin-4(3H)-one derivatives had been synthesized under microwave irradiation. The compounds were obtained from reaction some of benzoxazine derivatives with hydrazine hydrate using microwave irradiation and the result of reaction we obtained 82-96%. The products had been tested by IR, 1H-NMR, 13C-NMR and Mass Spectroscopy analysis. The using microwave irradiation was more effective and efficient to produce compounds 2,3-disubtituted quinazolin-4(3H)-one derivative because the reaction runs perfectly without any minor products such as compounds N-(2-(hydrazinecarbonyl)phenyl)benzamide derivatives.

Introduction: The aim of study was to analyze the pattern of malocclusion and their prevalence among patient visiting Dental College, Ranchi to establish baseline date for developing better treatment facility and future research Work. Settings and Design: All the patients were examined in a Dental Chair light and evaluation of Occlusion position in centric occlusion were recorded by asking the subject to swallow and then to Occlude. The samples were divided into Different groups, on the basis of Angle’s classification. A qualitative analysis with Angle’s classification was used to describe the anteroposterior relationship of maxillary and mandibular first molars. Material and Methods: The study was conducted on 1720 patients who attended the orthodontic department from February 2017 to January 2020. Each patient was examined for malocclusion, dentofacial patterns and dentofacial characteristics were recorded. The pattern and prevalence of different malocclusion was assessed. Results: The results of the study showed that most common malocclusion was Angles class I. Total of 1219 (70.66%) Patients reported with Angles Class I malocclusion. The second most common malocclusion was Angles Class II with Increase Over jet 392 (22.72%). The least common malocclusion was Angles Class III 37 (02.14%). Conclusion: Most Prevalent malocclusion among patient consulting for orthodontic treatment in Dental College, Ranchi is Angles Class I malocclusion. Among class I malocclusion crowding of teeth is more prevalent than spacing of teeth.