Bacterial resistance to antibacterial agents is of grave concern in the medical community, as many species of bacteria have evolved as resistant strains. In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. The synthesized benzothiazole derivatives were characterized physicochemically, by elemental analysis and spectral (IR and ¹H-NMR) analysis. All the synthesized compounds were screened for their in-vitro antibacterial activity against Gram-positive and Gram-negative bacteria. The results revealed that most of the compounds have better activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard Gentamicin and Amoxycillin and less active than the standard Ciprofloxacin. Further research can warrant more consideration on benzothiazoles as prospective antimicrobials.

Introduction: Despite many available therapies for wound healing, it’s  treatment still remains unsatisfactory.  Metformin by virtue of it’s  various actions like anti-inflammatory, anti oxidant and effect on hemostatic mechanisms can prove to be promising for the wound healing especially in diabetics. Materials and methods: Wistar rats were divided into two groups, (n=6 each group) and a wound was created which was treated with petroleum jelly in group A and petroleum jelly based Metformin cream in group B. The wound healing and epithelisation of wound was evaluated at day 4,8,12,16 and 20. Results: Group A showed an average wound size of 348±13.0 on day 4, 278±10.5 on day 8, 119±9.8 on day 12, 86±9.2 on day 16 and 100% wound healing was observed day 20 onwards. Group B showed an average wound measurement of 310±10.0 on day 4, 231±9.0 on day 8, 83±8.5 on day 12 and complete wound healing was observed day 16 onwards in the test group. Conclusion: Metformin   proved to be useful in wound healing.

A series of morpholine mannich base derivatives were synthesized by a single step reaction of morpholine with substituted benzaldehydes and N-phenylacetamide. Progress of reaction was monitored by TLC using ethylacetate and n-hexane as mobile phase. The compounds were characterized by ATR and ¹HNMR spectral analysis. Antioxidant assay of the synthesized compounds was done by DPPH and ABTS assay method using Ascorbic acid as standard. The synthesized morpholine mannich base derivatives demonstrated significant radical scavenging property.

Traditional techniques opted to treat cancer were found to be extremely harmful to the tissues when given at a slightly higher dose. ADCs (Antibody Drug Conjugates) have transformed the field of cancer chemotherapy. ADCs use monoclonal antibodies (mAbs) to explicitly tie tumour-related target antigens and convey an exceptionally powerful cytotoxic agent. The synergistic mix of mAbs conjugated to little molecule chemotherapeutics, through a stable linker, has given rise to an adequate class of anti-cancer drugs with an effectively extensive and quickly developing clinical pipeline. Antibody drug conjugates (ADCs) are an important division of therapeutics that allows the antigen-selective ability of mAbs to deliver highly potent cytotoxic drugs at the site of antigen-expressing tumour cells. The utilization of mAb coordinated delivery can present a high therapeutic index to exceptionally strong cytotoxic drugs, expanding both the efficacy and level of safety of the treatment. In other words, to achieve the goal of highly improved therapeutic efficacy and reduced toxicity, each component of an ADC i.e. the mAb, linker and the drug needs to be considered in context of targeted antigen. Furthermore, the mechanism of ADCs, characteristics of targets, methods of preparation, linker drugs being used in ADC design is discussed.