Review on Natural Polysaccharide Based Particulate Drug Delivery Systems: An Inimitable Tactic in Novel Drug Delivery Systems
Rohit Rajendra Bhosale, Riyaz Ali M. Osmani, Afrasim Moin.
Polysaccharides seem to be the most promising materials in the preparation of micro and nanometeric carriers. Micro and nanoparticles may be comprised of several kind materials being classified as nondegradable and biodegradable. Biodegradable systems have an advantage over nondegradable systems in that they are non-toxic, biocompatible, biodegradable, and water soluble. The application of natural polysaccharides in novel drug delivery systems to deliver the bioactive agents has been hampered by the synthetic polymers. The main benefits of the natural polysaccharides are their being biodegradable, biocompatible, non-toxic, richly available and less expensive. Because of the advances in drug delivery technology, natural polysaccharides are included in novel drug delivery to fulfill multitask functions. Substantial research efforts have been directed towards developing safe and efficient natural based polysaccharide particulate drug delivery systems. In this review, brief information on natural polysaccharides is covered. This review also covers modification techniques for natural polysaccharides and the newest developments in the preparation of polysaccharide based micro and nanoparticles with their characterization techniques and their applications are covered.
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